Results 71 to 80 of about 893,542 (163)

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH

, 2017
Stimulation of the cytosolic NAD+ dependent deacetylase SIRT1 is cardioprotective against ischemia-reperfusion (IR) injury. NAD+ precursors including nicotinamide mononucleotide (NMN) are thought to induce cardioprotection via SIRT1.
Yves T. Wang, Paul S. Brookes, Sergiy M. Nadtochiy, Joshua Munger, Keith Nehrke   +4 more
core   +1 more source

β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice. [PDF]

J Inflamm Res, 2021
Zhou X, Du HH, Long X, Pan Y, Hu J, Yu J, Zhao X.   +6 more
europepmc   +1 more source

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. [PDF]

Geroscience, 2023
Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V.   +9 more
europepmc   +1 more source

NMN/NAD+/SIRT1 axis activates NAMPT to ameliorate H2O2-triggered the impairment of progesterone synthesis in ovarian granulosa cells

Journal of Ovarian Research
Oxidative stress is a major driver of granulosa cell (GC) dysfunction and disrupted steroidogenesis. However, the mechanisms underlying oxidative stress–induced progesterone synthesis impairment and potential intervention strategies remain inadequately ...
Yunduan Wang, Qiao Li, Yueyue Li, Zifeng Ma, Hongmei Xu, Kechao Chen, Jian Li, Daoliang Lan, Wei Fu   +8 more
doaj   +1 more source

Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain

, 2022
As a redox-sensitive coenzyme, nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular energy metabolism and homeostasis. Low NAD+ levels are linked to multiple disease states, including age-related diseases, such as metabolic and ...
Ramanathan, Chidambaram, Zhang, Yufeng, Drake H. Williams, Bloomer, Richard J., Paul S. Simone, Lackie, Thomas, Chidambaram Ramanathan, Simone, Paul S., Williams, Drake H., Yufeng Zhang, Thomas Lackie, Richard J. Bloomer   +11 more
core   +1 more source

Dietary Nicotinamide Mononucleotide, a Key NAD⁺ Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in db/db Mice

Metabolites
Background/Objectives: Supplementation with nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD+) intermediate, exerts anti-aging, anti-obesity, and anti-diabetic effects in animal experiments.
Bungo Shirouchi, Sarasa Mitsuta, Mina Higuchi, Mai Okumura, Kazunari Tanaka   +4 more
doaj   +1 more source

Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite that plays a crucial role in diverse biological processes, including energy metabolism, gene expression, DNA repair, and mitochondrial function.
Guang Yang, Ningning Wang, Yu Ma, Haoyuan Deng, Cong Zhang, Hao Zhang, Ding Ding   +6 more
core   +1 more source

Implications of altered NAD metabolism in metabolic disorders

Journal of Biomedical Science, 2019
Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation.
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe, Takashi Nakagawa   +3 more
doaj   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science
The brain plays a central role in aging and longevity in diverse model organisms. Morphological and functional alteration in the aging brain elicits age‐associated neuronal dysfunctions. However, the primary mechanism deteriorating the brain functions to
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
doaj   +1 more source

The versatile multi-functional substance NMN: its unique characteristics, metabolic properties, pharmacodynamic effects, clinical trials, and diverse applications

Frontiers in Pharmacology
β-nicotinamide mononucleotide (NMN) is a naturally occurring biologically active nucleotide widely present in organisms and an inherent substance in the human body.
Bin Yu, Bin Yu, Xiaotong Jing, Lina Jia, Maoru Wang, Liying Liu, Songyuge Ping, Yu Wang, Min Yang   +8 more
doaj   +1 more source