Results 61 to 70 of about 893,542 (163)

Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside [PDF]

, 2020
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are effective substrates for NAD synthesis, which may act as vasoprotective agents. Here, we characterize the effects of NMN and NR on endothelial inflammation and dysfunction and test the ...
Mateuszuk, Łukasz, Campagna, Roberto, Słomińska, Ewa M., Kutryb-Zając, Barbara, Chłopicki, Stefan, Kuś, Kamil, Smolenski, Ryszard T.   +6 more
core   +1 more source

Nicotinamide Mononucleotide Potentiates Resistance to Biotrophic Invasion of Fungal Pathogens in Barley

, 2021
Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD), induces disease resistance to the Fusarium head blight fungus Fusarium graminearum in Arabidopsis and barley, but it is unknown at which stage of the infection it ...
Hiroshi Inoue, Takashi Yaeno, Yuichi Nakajima, Takumi Nishiuchi, Kana Ueda, Kappei Kobayashi, Makoto Kimura   +6 more
core   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

NMN protects cisplatin-associated AKI via NAD+/SIRT1 pathway

Frontiers in Immunology
Acute kidney injury (AKI) is a critical public health concern with high morbidity and mortality. The chemotherapy agent cisplatin is widely used for various solid tumors; however, cisplatin-associated AKI (CIS-AKI) is a frequent complication in the ...
Zhaozhi Wen, Zhaozhi Wen, Jiazeng Wang, Yihang Yang, Longlong Chen, Xiangge Ji, Dong Liu, Chongxu Shi   +7 more
doaj   +1 more source

β-Nicotinamide mononucleotide improves chilled ram sperm quality in vitro by reducing oxidative stress damage [PDF]

Animal Bioscience
Objective The present study aimed to investigate the effect of β-nicotinamide mononucleotide (NMN) supplementation on ram sperm quality during storage at 4°C in vitro. Methods Tris-citric acid-glucose solution containing different doses of NMN (0, 30, 60,
Zhendong Zhu, Haolong Zhao, Qitai Yang, Yajing Li, Ruyuan Wang, Adedeji Olufemi Adetunji, Lingjiang Min   +6 more
doaj   +1 more source

Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy

Aging Cell, Volume 25, Issue 8, August 2026.
MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco, Irene Bernardi, Aretha Rambaldi, Pierluigi Lombardi, Maura Rossi, Francesca Paris, Lucia Manzoli, Stefano Ratti, Francesco Alviano   +8 more
wiley   +1 more source

Slc12a8 is a nicotinamide mononucleotide transporter

, 2019
Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+ known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels.
Mills, Kathryn F, Sasaki, Yo, Lei, Hanyue Cecilia, Yoshino, Jun, Tokizane, Kyohei, Imai, Shin-Ichiro, Sociali, Giovanna, Grozio, Alessia, Bruzzone, Santina, Migaud, Marie E, Cunningham, Richard   +10 more
core   +1 more source

Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic–Ischemic Brain Injury in Neonatal Mice

, 2023
A clinical challenge remains in the treatment of hypoxic–ischemic brain injury in newborns. Nicotinamide adenine dinucleotide (NAD + ) has beneficial effects in animal models of adult stroke.
Tetyana Chumak, Carina Mallard, Hagberg, Henrik,, Seyedeh Marziyeh Jabbari Shiadeh, Chumak, Tetyana,, Singh-Mallah, Gagandeep,, Sandberg, Mats,, Ikeda, T., Kawamura, Takuya,, Svedin, Pernilla,, Gagandeep Singh Mallah, Maryam Ardalan, Fanny Goretta, Tomoaki Ikeda, Goretta, Fanny,, Mallard, Carina,, Mats Sandberg, Pernilla Svedin, Henrik Hagberg, Ardalan, Maryam,, Jabbari Shiadeh, Seyedeh Marziyeh,, Takuya Kawamura, Lina Jonsson, Jonsson, Lina   +23 more
core   +1 more source

Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis. [PDF]

, 2020
Biological production of chemicals often requires the use of cellular cofactors, such as nicotinamide adenine dinucleotide phosphate (NADP+). These cofactors are expensive to use in vitro and difficult to control in vivo.
Cui, Youtian, Fong, Bonnie, Maxel, Sarah, King, Edward, Siegel, Justin B, Li, Han, Zhang, Linyue, Mak, Wai Shun, Black, William B, Sanchez Martinez, Alicia   +9 more
core   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source