Results 41 to 50 of about 893,542 (163)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

, 2021
BACKGROUND: The activation of NAD(+)-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases.
Yasuda, Itaru, Hirobumi Tokuyama, Shu Wakino, Ei Kusahana, Takashi Ono, Hiroshi Itoh, Kusahana, Ei, Takeshi Kanda, Muraoka, Hirokazu, Tokuyama, Hirobumi, Kanda, Takeshi, Yusuke Sakamaki, Itoh, Hiroshi, Takahisa Kawaguchi, Sakamaki, Yusuke, Wakino, Shu, Ono, Takashi, Kazuhiro Hasegawa, Hirokazu Muraoka, Kawaguchi, Takahisa, Itaru Yasuda, Hasegawa, Kazuhiro   +21 more
core   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells [PDF]

, 2017
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear
Migaud, Marie E., Lucy A. Oakey, Rachel S. Fletcher, Carles Canto, Brenner, C, Migaud, ME, Oakey, Lucy A, Gabriella Da Silva Xavier, Joanna Ratajczak, Craig L. Doig, Philp, A, Lavery, Gareth G., Canto, Carles, Da Silva Xavier, Gabriella; id_orcid, Canto, C, Garten, Antje, Oakey, Lucy A., Elhassan, Yasir S., Lavery, GG, Yasir S. Elhassan, Elhassan, Yasir S; id_orcid, Elhassan, YS, Ratajczak, Joanna, Callingham, Rebecca, Fletcher, RS, Redpath, P, Antje Garten, Garten, A, Xavier, Gabriella Da Silva, Da Silva Xavier, G, Oakey, LA, Doig, Craig L., Fletcher, Rachel S., Andrew Philp, Gareth G. Lavery, Migaud, Marie E, Brenner, Charles, Charles Brenner, Marie E. Migaud, Ratajczak, J, Callingham, R, Rebecca Callingham, Philp, Andrew, Doig, CL, Doig, Craig L, Redpath, Philip, Lavery, Gareth G, Philip Redpath, Fletcher, Rachel S   +48 more
core   +1 more source

Fortification Technology and Quality Evaluation of β-Nicotinamide Mononucleotide in Fermented Coix Seed

Shipin gongye ke-ji
The aim of this study was to develop a fermented food rich in β-nicotinamide mononucleotide (β-NMN). The influence of fermentation strain, fermentation time, and addition of B-group vitamins on the β-NMN content of fermented Coix (Coix lacryma-jobi) seed
Caihua LIU, Riying HUANG, Xinyun MAI, Rongfeng LI, Qiuliu LIU, Guojiao WANG, Lingling LÜ   +6 more
doaj   +1 more source

Effects of β-Nicotinamide Mononucleotide, Berberine, and Cordycepin on Lipid Droplet Content and Developmental Ability of Vitrified Bovine Oocytes

Antioxidants, 2023
Oocyte vitrification is crucial for livestock reproduction, germplasm conservation, and human-assisted reproduction, but the overabundance of lipids is highly detrimental to oocyte development.
Xi Xu, Baigao Yang, Hang Zhang, Xiaoyi Feng, Haisheng Hao, Weihua Du, Huabin Zhu, Adnan Khan, Muhammad Zahoor Khan, Peipei Zhang, Xueming Zhao   +10 more
doaj   +1 more source

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source

Structure of nicotinamide mononucleotide adenylyltransferase: a key enzyme in NAD+ biosynthesis [PDF]

, 2000
Background: Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor involved in fundamental processes in cell metabolism. The enzyme nicotinamide mononucleotide adenylyltransferase (NMN AT) plays a key role in NAD+ biosynthesis, catalysing the ...
Menico Rizzi, Teresa Lorenzi, Valerio Dabusti, Rizzi, Menico, D’Angelo, Igor, Lorenzi, Teresa, Dabusti, Valerio, Raffaelli, Nadia, Giulio Magni, Igor D’Angelo, Nadia Raffaelli, Magni, Giulio   +11 more
core   +1 more source