Results 31 to 40 of about 893,542 (163)

Nicotinamide mononucleotide and nicotinamide riboside attenuate cytokine production in human keratinocytes via suppression of p38 Pathway. [PDF]

Mol Biol Rep
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by impaired epidermal barrier function and immune dysregulation.
Xie C, Velandia MAM, Marecek S, Khalil M, Hao J.   +4 more
europepmc   +2 more sources

Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance

, 2021
Recently, a study published in Science by Yoshino et al.1 reported on a randomized, placebo-controlled, double-blind clinical trial to examine the effects of a 10-week nicotinamide mononucleotide (NMN) administration on human metabolism in 25 ...
Roos, Julian, Pamela Fischer-Posovszky, Julia Zinngrebe, Fischer-Posovszky, Pamela, Zinngrebe, Julia, Julian Roos   +5 more
core   +1 more source

Nicotinamide mononucleotide production by non-recombinant Limosilactobacillus reuteri and nicotinamide adenine dinucleotide synthesizing lactic acid bacteria

Microbiology Spectrum
β-nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide (NAD+) and has the potential to suppress aging. Certain strains of lactic acid bacteria (LAB) can produce cofactors and vitamins through fermentation.
Satoru Ozaki, Yoshiko Honme, Masashi Morifuji   +2 more
doaj   +1 more source

Streamlining Design, Engineering, and Applications of Nicotinamide Riboside Kinase for Sustainable Biosynthesis of Nicotinamide Mononucleotide in Flow

, 2023
The market demand for β-nicotinamide mononucleotide (NMN), an antiaging health product, is rapidly expanding. Consequently, there is an urgent requirement for an environment-friendly and economical approach to synthesize NMN.
Ke-Xin Li (12459120), Qian Guo (107009), Feng Cheng, Ya-Ping Xue, Huan Li (120482), Qi Shen, Yu-Guo Zheng, Ya-Ping Xue (427998), Feng Cheng (124653), Yu-Guo Zheng (427999), Xiao-Hu Wu, Huan Li, Ke-Xin Li, Qian Guo, Qi Shen (166827), Xiao-Hu Wu (17109342)   +15 more
core   +1 more source

Effect of β-Nicotinamide Mononucleotide on the Growth Promotion of Caenorhabditis elegans and Its Mechanism

Shipin gongye ke-ji, 2023
Objective: To study the effect of β-nicotinamide mononucleotide (NMN) on the growth of Caenorhabditis elegans (C. elegans) and its mechanism. Methods: Nematodes were randomly divided into blank control group and experimental groups with different ...
Shu LI, Yuqin TONG, Shulin YANG, Yang YANG, Mansi NIU, Fuli WEN, Shan ZENG, Caihong SHEN, Jian ZHAO, Songtao WANG   +9 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells [PDF]

, 2016
NAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside
Boutant, Marie, Migaud, Marie E., Ratajczak, Joanna, Ras, Rosa, Trammell, Samuel A. J., Auwerx, Johan, Trammell, Samuel A.J., Kulkarni, Sameer S., Yanes, Oscar, Joffraud, Magali, Trammell, Samuel A J, Rodrigues, Marcelo, Redpath, Philip, Canela, Nuria, Brenner, Charles, Cantó, Carles   +15 more
core   +3 more sources

Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with β-NMN

Journal of Pharmacological Sciences, 2023
We have no definitive treatment for dementia characterized by prolonged neuronal death due to the enormous accumulation of foreign matter, such as β-amyloid.
Nanae Takahashi, Norio Akaike, Tomohisa Nagamatsu, Hiroyuki Uchino, Yoshihisa Kudo   +4 more
doaj   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source