Results 11 to 20 of about 893,542 (163)

Enhanced Production of β-Nicotinamide Mononucleotide with Exogenous Nicotinamide Addition in Saccharomyces boulardii-YS01

Foods, 2023
β-Nicotinamide mononucleotide (NMN), as a key precursor of an essential coenzyme nicotinamide adenine dinucleotide (NAD+), is most recognized for its pathological treatment effects and anti-aging functions.
Meijie Song, Chunhua Yin, Qianqian Xu, Yang Liu, Haiyang Zhang, Xiaolu Liu, Hai Yan   +6 more
doaj   +2 more sources

β-Nicotinamide mononucleotide protects against hypervirulent Klebsiella pneumoniae bloodstream infection and liver injury

mSphere
In clinical practice, hypervirulent Klebsiella pneumoniae (hvKP) often causes bloodstream infections (BSI) and liver abscesses; however, the mechanism of hvKP-induced liver abscess formation remains unclear.
Zubai Cao, Bao Meng, Jie Chen, Ruomu Ge, Yanyan Liu, Jiabin Li   +5 more
doaj   +2 more sources

De novo biosynthesis and nicotinamide biotransformation of nicotinamide mononucleotide by engineered yeast cells

Microbial Biotechnology
β‐Nicotinamide mononucleotide (NMN) is a precursor of NAD+ in mammals. Research on NAD+ has demonstrated its crucial role against aging and disease. Here two technical paths were established for the efficient synthesis of NMN in the yeast Pichia pastoris,
Yanna Ren, Bei Han, Shijie Wang, Xingbin Wang, Qi Liu, Menghao Cai   +5 more
doaj   +2 more sources

Biosynthesis of β-nicotinamide mononucleotide from glucose via a new pathway in Bacillus subtilis [PDF]

Frontiers in Microbiology
Introductionβ-nicotinamide mononucleotide (β-NMN) is an essential precursor of nicotinamide adenine dinucleotide (NAD+) and plays a key role in supplying NAD+ and maintaining its levels.
Zhilei Tan, Yihang Yang, Yannan Wu, Jiajia Yan, Bin Zhang, Ying Hou, Shiru Jia   +6 more
doaj   +2 more sources

Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver

Cells, 2022
It is known that the activities of nicotine adenine dinucleotide (NAD+)-dependent deacetylase decline in the aging mouse liver, and nicotinamide mononucleotide (NMN)-mediated activation of deacetylase has been shown to increase healthspans.
Chengting Luo, Wenxi Ding, Songbiao Zhu, Yuling Chen, Xiaohui Liu, Haiteng Deng   +5 more
doaj   +2 more sources

β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Molecules
β-Nicotinamide mononucleotide (NMN) has shown promising effects on intestinal health, and it is extensively applied as an anti-aging and Alzheimer’s disease therapeutic, due to its medicinal properties. The effects of NMN on the growth of mouse hair were
Chuntao Xu, Jiawei Dai, Hongxia Ai, Weian Du, Hongbing Ji   +4 more
doaj   +2 more sources

Determination of β-Nicotinamide Mononucleotide (NMN) in NMN Cross Border Products

Shipin gongye ke-ji, 2022
By optimizing the chromatographic conditions and sample pretreatment conditions, a method for determination of NMN content in NMN capsules and NMN tablets matrix was established based on high performance liquid chromatography, and the methodology was ...
Wenyu ZHANG, Tao LAN, Xi ZHAO, Qi WU, Qiao CHU, Congcong YU, Dahong WANG, Weibing ZHANG, Zhenyu YUN   +8 more
doaj   +1 more source

Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide

Microbial Biotechnology, 2021
Summary The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme for cellular redox reactions, NAD. Administration of NMN is reported to improve various symptoms, such as diabetes and age‐related physiological decline. Thus,
Yang Liu, Montri Yasawong, Bo Yu
doaj   +1 more source

Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

Nature Communications, 2022
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in ...
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao   +24 more
doaj   +1 more source

Enzymatic synthesis of high-titer nicotinamide mononucleotide with a new nicotinamide riboside kinase and an efficient ATP regeneration system

Bioresources and Bioprocessing, 2022
Background β-Nicotinamide mononucleotide (NMN) is the direct precursor of nicotinamide coenzymes such as NAD+ and NADP+, which are widely applied in industrial biocatalysis especially involving cofactor-dependent oxidoreductases.
Xiao-Long Qian, Yi-Si Dai, Chun-Xiu Li, Jiang Pan, Jian-He Xu, Bozhong Mu   +5 more
doaj   +1 more source