Results 51 to 60 of about 893,542 (163)

The Role of SIRT1 in Mediating Bone Marrow Edema and Its Interface With Bone Remodeling

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Bone marrow edema (BME), a common magnetic resonance imaging (MRI) finding characterized by increased fluid signal, is associated with pain and structural deterioration in conditions such as osteoarthritis and avascular necrosis. The pathophysiology of BME involves a complex interplay of vascular leakage, inflammation, microdamage ...
Yiming Chen, Xinyue Li, Zhongji Zheng, Zhihong Liu, Tao Xu, Yuanyi Tang   +5 more
wiley   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Administration of β-Nicotinamide Mononucleotide Attenuates Myocardial Dysfunction in Tail-Suspended Mice

Journal of Cardiovascular Pharmacology and Therapeutics
Microgravity conditions cause myocardial atrophy and dysfunction with limited therapeutics. Accumulating evidence demonstrates that the deficiency of nicotinamide adenine dinucleotide (NAD + ) contributes to myocardial dysfunction under microgravity ...
Wenyu Gu MSc, Dan Liu PhD, Lei Wei MSc, Ziying Yang MSc, Shumin Jiang MSc, Shiyu Dai PhD, Ting Cao PhD, Zhenya Shen PhD   +7 more
doaj   +1 more source

NAD+ Metabolic Reprogramming Drives CD8+ T Cells Senescence and Exacerbates Ulcerative Colitis

Aging Cell, Volume 25, Issue 9, September 2026.
Nicotinamide adenine dinucleotide (NAD+) depletion induces mitochondrial dysfunction and cytosolic mtDNA leakage in CD8+ T cells, activating the cGAS‐STING pathway and promoting a senescence‐associated secretory phenotype (SASP). The resulting pro‐inflammatory CD8+ T cells release IFN‐γ and TNF‐α, disrupt the intestinal epithelial barrier, and ...
Maolin Ye, Qi Zhou, Mingjia Kong, Suhan Zhao, Lingxi Lin, Lirong Chen, Jianghong Yu, Feifei Luo, Jie Liu, Jun Zhang   +9 more
wiley   +1 more source

β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway

Antioxidants
Oxidative stress is a significant factor in the death of granulosa cells (GCs), leading to follicular atresia and consequently limiting the number of dominant follicles that can mature and ovulate within each follicular wave.
Yu Cai, Hua Yang, Hui Xu, Shanglai Li, Bingru Zhao, Zhibo Wang, Xiaolei Yao, Feng Wang, Yanli Zhang   +8 more
doaj   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Integrative simulation analysis of myocardial ischaemia–reperfusion injury

The Journal of Physiology, Volume 604, Issue 18, Page 7640-7662, 15 September 2026.
Abstract figure legend A comprehensive mathematical model of ventricular myocyte was developed to gain insights into the mechanisms underlying cardiac ischaemia–reperfusion injury. The model integrates excitation–contraction (E–C) coupling, cytosolic and mitochondrial pH regulation, pH dependence of major E–C coupling components and cellular energy ...
Takao Shimayoshi, Ayako Takeuchi, Satoshi Matsuoka   +2 more
wiley   +1 more source

Biosynthesis of Nicotinamide Mononucleotide: Current Metabolic Engineering Strategies, Challenges, and Prospects

, 2023
Nicotinamide mononucleotide (NMN) is an essential precursor of nicotinamide adenine dinucleotide (NAD+), which is widely applied in the pharmaceutical and biotech industries.
Tao Chen, Shiqi Luo, Yangyang Zheng, Juntao Zhao, Zhiwen Wang   +4 more
core   +1 more source

Nicotinamide Mononucleotide (NMN) Improves the Senescence of Mouse Vascular Smooth Muscle Cells Induced by Ang II Through Activating p-AMPK/KLF4 Pathway

Pharmaceuticals
Background: Vascular smooth muscle cells (VSMCs) senescence exacerbates vascular diseases like atherosclerosis and hypertension. Angiotensin II (Ang II) is a strong inducer of VSMCs senescence, causing vascular damage, though its exact mechanism is ...
Na Liang, Si Liu, Yan Wang, Linyao Ying, Keyi Zhang, Hao Li, Lin Xiao, Yuming Hu, Gang Luo   +8 more
doaj   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, Volume 13, Issue 46, 17 August 2026.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source