Results 21 to 30 of about 8,460 (141)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase [PDF]

Frontiers in Physiology, 2014
Amyloid β-protein (Aβ) plays a central role in the pathogenesis of Alzheimer's disease, the most common age-associated neurodegenerative disorder. Aβ is generated through intramembrane proteolysis of the β-carboxyl terminal fragment (βCTF) of β-amyloid precursor protein (APP) by γ-secretase.
openaire   +3 more sources

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP.

PLoS ONE, 2017
α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP.
Hazel L Roberts, Bernard L Schneider, David R Brown   +2 more
doaj   +1 more source

Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell

Marine Drugs, 2021
The proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase releases amyloid-β peptide (Aβ), which deposits in amyloid plaques and contributes to the initial causative events of Alzheimer’s disease (AD).
Jeong-Hyun Yoon, Nayoung Lee, Kumju Youn, Mi Ra Jo, Hyeung-Rak Kim, Dong-Seok Lee, Chi-Tang Ho, Mira Jun   +7 more
doaj   +1 more source

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline [PDF]

, 2016
Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the
Cranston, Anna, Gardner, Heidi, Jones, Glynn, Kanaan, Nicholas M., Koss, David J., Platt, Bettina   +5 more
core   +3 more sources

Purification and characterization of β-secretase inhibitory peptide from sea hare (Aplysia kurodai) by enzymatic hydrolysis

Fisheries and Aquatic Sciences, 2018
Amyloid plaque, also called senile plaque, the product of aggregation of β-amyloid peptides (Aβ), is observed in brains of the patients with Alzheimer’s disease (AD) and is one of the key factors in etiology of the disease.
Jung Kwon Lee, Sung Rae Kim, Hee-Guk Byun   +2 more
doaj   +1 more source

High resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.

PLoS ONE, 2014
Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by the ...
Katarina Jovanovic, Ben Loos, Bianca Da Costa Dias, Clement Penny, Stefan F T Weiss   +4 more
doaj   +1 more source

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. [PDF]

PLoS ONE, 2011
BackgroundAlzheimer's disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life.
Naoki Yahata, Masashi Asai, Shiho Kitaoka, Kazutoshi Takahashi, Isao Asaka, Hiroyuki Hioki, Takeshi Kaneko, Kei Maruyama, Takaomi C Saido, Tatsutoshi Nakahata, Takashi Asada, Shinya Yamanaka, Nobuhisa Iwata, Haruhisa Inoue   +13 more
doaj   +1 more source

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. [PDF]

, 2012
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease.
Bardy, Cedric, Boscolo, Francesca S, Carson, Christian T, Gage, Fred H, Goldstein, Lawrence SB, Hefferan, Michael P, Herrera, Cheryl, Israel, Mason A, Koo, Edward H, Laurent, Louise C, Marsala, Martin, Mu, Yangling, Nazor, Kristopher L, Remes, Anne M, Reyna, Sol M, Van Gorp, Sebastiaan, Yuan, Shauna H   +16 more
core   +3 more sources

Selective amyloid-β lowering agents [PDF]

, 2012
The amyloid-\(\beta\) peptide (A\(\beta\)), implicated in the pathogenesis of Alzheimer's disease (AD), is produced through sequential proteolysis of the A\(\beta\) precursor protein (APP) by \(\beta\)- and \(\gamma\)-secretases. Thus, blocking either of
Michael S Wolfe, D Beher, DR Howlett, H Cai, Y Luo, M Willem, L Hong, AK Ghosh, MS Wolfe, R Kopan, GH Searfoss, GT Wong, S Weggen, S Weggen, Y Zhou, T Sato, TL Kukar, WJ Netzer, PC Fraering, P Bakshi   +19 more
core   +1 more source

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Neurobiology of Disease, 2013
Proteolytic cleavage of the amyloid precursor protein (APP) by the two proteases α- and β-secretases controls the generation of the amyloid β peptide (Aβ), a key player in Alzheimer's disease pathogenesis. The α-secretase ADAM10 and the β-secretase BACE1
Alessio Colombo, Huanhuan Wang, Peer-Hendrik Kuhn, Richard Page, Elisabeth Kremmer, Peter J. Dempsey, Howard C. Crawford, Stefan F. Lichtenthaler   +7 more
doaj   +1 more source