Results 31 to 40 of about 8,460 (141)

Effects of hypertension and anti-hypertensive treatment on Aβ plaque load, Aβ–synthesising and –degrading enzymes in frontal cortex [PDF]

, 2016
Epidemiological data associate hypertension with a predisposition to Alzheimer’s disease (AD), and a number of postmortem and in vivo studies also demonstrate that hypertension increases amyloid-β (Aβ) pathology.
Ashby, Emma L, Kehoe, Patrick Gavin, Love, Seth, Miners, J S   +3 more
core   +2 more sources

Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes

Cell Reports, 2021
Summary: Axonal generation of Alzheimer’s disease (AD)-associated amyloid-β (Aβ) plays a key role in AD neuropathology, but the cellular mechanisms involved in its release have remained elusive.
Raja Bhattacharyya, Sophia E. Black, Madhura S. Lotlikar, Rebecca H. Fenn, Mehdi Jorfi, Dora M. Kovacs, Rudolph E. Tanzi   +6 more
doaj   +1 more source

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta [PDF]

, 2017
Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer’s disease are associated with mutations in APP that increase toxic ...
A Bour, B Kozera, C Haass, C Haass, CJ Taylor, D Kogel, D Schubert, DM Mann, E Kojro, E Thornton, EM Mutisya, F Corrigan, F Corrigan, FS Esch, HK Anandatheerthavarada, I Trounce, IA Trounce, J Clarke, JE Pierce, JK Parks, JO Holloszy, JR Ciallella, JT Jarrett, KJ Livak, L Devi, M Citron, M Gralle, M Manczak, M Mullan, MI Sanchez, MI Sanchez, MP Murphy, MS Forman, N Krako, N Milosch, ND Belyaev, NJ Bergen Van, O Rackham, PD Ray, PH Reddy, PJ Crouch, PM Schaefer, R Vassar, RS Williams, S Ayton, S Hauptmann, S Plummer, SC Lim, SJ Kish, SJ Kish, SM Cardoso, T Harkany, T Itoh, TT Yang, U Keil, V Rhein, V Rhein, V Shukla, VA Morais, WD Parker Jr., X Wang, Y Goodman   +61 more
core   +3 more sources

The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients [PDF]

, 2020
Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy referred for surgery due to antiepileptic drug (AED) resistance. A common molecular target for many of these drugs is the voltage-gated sodium channel (VGSC).
Falciani, Francesco, Princivalle, Alessandra, Sheilabi, Mariam A., Sims, Edward J., Takeshita, Louise Y.   +4 more
core   +1 more source

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity [PDF]

, 2014
Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has led to advanced human trials of Aβ-lowering agents.
Klyubin, Igor, Li, Shaomin, Maggio, John E., Ostaszewski, Beth L., Rowan, Michael J., Selkoe, Dennis J., Seubert, Peter, Shankar, Ganesh M., Walker, Donald E., Walsh, Dominic M., Welzel, Alfred T.   +10 more
core   +2 more sources

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

Molecular Neurodegeneration, 2012
Background A mutation in the BRI2/ITM2b gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis.
Tamayev Robert, D’Adamio Luciano
doaj   +1 more source

The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner

Scientific Reports, 2022
Genome-wide association studies have identified BIN1 (Bridging integrator 1) and RIN3 (Ras and Rab interactor 3) as genetic risk factors for late-onset Alzheimer’s disease (LOAD).
Raja Bhattacharrya, Catarina Amelia Fidalgo Teves, Alexandra Long, Madison Hofert, Rudolph E. Tanzi   +4 more
doaj   +1 more source

Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment

Ecotoxicology and Environmental Safety, 2021
Excessive exposure to manganese (Mn) can cause cognitive impairment, a common feature of Alzheimer's disease (AD), but the mechanisms remain unclear. Amyloid precursor protein (APP) is key to AD pathogenesis, and whether APP and its secretase processing ...
Yiping Yang, Jie Zhang, Xiaobo Yang, Zhiying Li, Jian Wang, Cailing Lu, Aruo Nan, Yunfeng Zou   +7 more
doaj   +1 more source

Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.

PLoS ONE, 2014
The potential similarity between the brain pathology of idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer disease (AD) is intriguing and thus further studies focusing on the underlying molecular mechanisms may offer valuable information for ...
Tiina Laiterä, Timo Sarajärvi, Annakaisa Haapasalo, Lakshman Puli, Tarja Kauppinen, Petra Mäkinen, Tuomas Rauramaa, Heikki Tanila, Juha E Jääskeläinen, Irina Alafuzoff, Hilkka Soininen, Ville Leinonen, Mikko Hiltunen   +12 more
doaj   +1 more source

Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology. [PDF]

, 2014
Our understanding of Alzheimer's disease (AD) is still incomplete and, as a result, we lack effective therapies. Reprogramming to generate human-induced pluripotent stem cells provides a new approach to the generation of human neurons that carry the ...
Goldstein, Lawrence SB, Reyna, Sol, Woodruff, Grace   +2 more
core   +1 more source