Results 141 to 150 of about 29,069 (201)

In silico study of selected alkaloids as dual inhibitors of β- and γ-secretases for Alzheimer's disease [PDF]

Isreal Ayobami Onifade, Haruna Isiyaku Umar, Abdullahi Tunde Aborode, Aeshah A. Awaji, Ifeoluwapo Deborah Jegede, Bunmi Helen Adeleye, Dorcas Oladayo Fatoba, Ridwan Opeyemi Bello, Sodiq Fakorede, Nike Idowu   +9 more
openalex   +1 more source

The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics. [PDF]

Int J Biol Sci, 2023
Song C, Zhang J, Xu C, Gao M, Li N, Geng Q.   +5 more
europepmc   +1 more source

Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase [PDF]

, 2005
Yue Qi-Takahara, Maho Morishima‐Kawashima, Yu Tanimura, Georgia Dolios, Naoko Hirotani, Yuko Horikoshi, Fuyuki Kametani, Masahiro Maeda, Takaomi C. Saido, Rong Wang, Yasuo Ihara   +10 more
openalex   +1 more source

eLife Assessment: Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

Volker Dötsch
openalex   +1 more source

Protective effect and mechanism of γ-secretase inhibitor on myocardial injury in sepsis rats. [PDF]

, 2023
Jingyun Fang, Yuming Zhou
openalex  

γ-Secretase in Alzheimer's disease. [PDF]

Exp Mol Med, 2022
Hur JY.
europepmc   +1 more source

Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors. [PDF]

N Engl J Med, 2023
Gounder M, Ratan R, Alcindor T, Schöffski P, van der Graaf WT, Wilky BA, Riedel RF, Lim A, Smith LM, Moody S, Attia S, Chawla S, D'Amato G, Federman N, Merriam P, Van Tine BA, Vincenzi B, Benson C, Bui NQ, Chugh R, Tinoco G, Charlson J, Dileo P, Hartner L, Lapeire L, Mazzeo F, Palmerini E, Reichardt P, Stacchiotti S, Bailey HH, Burgess MA, Cote GM, Davis LE, Deshpande H, Gelderblom H, Grignani G, Loggers E, Philip T, Pressey JG, Kummar S, Kasper B.   +40 more
europepmc   +1 more source

Effects of RNA Interference-mediated Silencing of γ-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation

, 2004
Zhongcong Xie, Donna Romano, Dora M. Kovacs, Rudolph E. Tanzi   +3 more
openalex   +1 more source

γ-secretase targeting in Alzheimer's disease. [PDF]

J Alzheimers Dis Rep
Du L, Li G, Wei Y, Han G.
europepmc   +1 more source

Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease. [PDF]

Neuron, 2023
Essayan-Perez S, Südhof TC.
europepmc   +1 more source