Results 51 to 60 of about 201,597 (153)

δ-Tocotrienol induces p27^Kip1 expression and inhibits RAS-MEK-ERK signaling.

, 2013
A, pancreatic cancer and HPDE6 C7 cells were treated with δ-tocotrienol at predetermined IC50 for each cell line. Protein lysates from 0–48 hours were collected and analyzed by Western blot analysis for Ras oncogenic signaling targets, MEK and ERK, and ...
Kazim Husain (285140), Anying Zhang (170940), Mokenge P. Malafa (285152), Yanbin Dong (24525), Jose M. Pimiento (285141), Dung-Tsa Chen (285149), Domenico Coppola (53952), Rony Francois (285144), Jiandong Chen (220306), Said M. Sebti (251548), Pamela J. Hodul (285137), Warren J. Pledger (285146)   +11 more
core   +1 more source

Protective Effects of Duchesnea chrysantha Ethanol Extract Against UVB‐Induced Skin Damage via Modulation of TAK1‐Associated Signaling Pathways

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
An ethanol extract of Duchesnea chrysantha attenuates UVB‐induced oxidative stress, cell death, and inflammatory responses in keratinocytes while modulating extracellular‐matrix‐related markers in keratinocytes and dermal fibroblasts. These protective effects are associated with reduced TAK1 activation and suppression of NF‐κB, AP‐1, and MAPK signaling,
Yerkyesh Khamit, Lei Huang, Yena Oh, Jinghan Su, Dilda Kaskadamova, Segon Jang, Weizhaole Wei, Sarah Lee, Eun Sil Kim, Youn Kyoung Son, Byong Chul Yoo, Jongsung Lee, Jae Youl Cho   +12 more
wiley   +1 more source

p27^Kip1 is required for δ-tocotrienol-induced G₁ arrest.

, 2013
A, p27Kip1 siRNA attenuates δ-tocotrienol-mediated growth suppression in human MIAPaCa-2 pancreatic cancer cells. After transfection with p27Kip1 siRNA or with noncoding siRNA for 24 hours, MIAPaCa-2 cells were incubated with fresh medium containing ...
Kazim Husain (285140), Anying Zhang (170940), Mokenge P. Malafa (285152), Yanbin Dong (24525), Jose M. Pimiento (285141), Dung-Tsa Chen (285149), Domenico Coppola (53952), Rony Francois (285144), Jiandong Chen (220306), Said M. Sebti (251548), Pamela J. Hodul (285137), Warren J. Pledger (285146)   +11 more
core   +1 more source

A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β

Molecules, 2020
Garcinoic acid has been identified as an inhibitor of DNA polymerase β (pol β). However, no structure-activity relationship (SAR) studies of garcinoic acid as a pol β inhibitor have been conducted, in part due to the lack of an efficient synthetic method
Satheesh Gujarathi, Maroof Khan Zafar, Xingui Liu, Robert L. Eoff, Guangrong Zheng   +4 more
doaj   +1 more source

Genome-wide association studies reveal novel QTLs, QTL-by-environment interactions and their candidate genes for tocopherol content in soybean seed

Frontiers in Plant Science, 2022
Genome-wide association studies (GWAS) is an efficient method to detect quantitative trait locus (QTL), and has dissected many complex traits in soybean [Glycine max (L.) Merr.].
Kuanwei Yu, Huanran Miao, Hongliang Liu, Jinghang Zhou, Meinan Sui, Yuhang Zhan, Ning Xia, Xue Zhao, Yingpeng Han   +8 more
doaj   +1 more source

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev   +5 more
wiley   +1 more source

Impact of delta-tocotrienol on human melanoma cell proliferation [PDF]

, 2010
The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of growth-related proteins including nuclear Ras, nuclear lamins, and ...
Fernandes, Nicolle Valerie
core   +4 more sources

Efficacy of Off-Label Therapy for Non-alcoholic Fatty Liver Disease in Improving Non-invasive and Invasive Biomarkers: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Frontiers in Medicine, 2022
ObjectiveTo evaluate the effects of vitamin E, pioglitazone, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists in patients with non-alcoholic fatty liver disease (NAFLD).DesignA network meta-analysis.
Qian Luo, Qian Luo, Ruojun Wei, Ruojun Wei, Yuzi Cai, Yuzi Cai, Qihan Zhao, Qihan Zhao, Yuning Liu, Yuning Liu, Wei Jing Liu, Wei Jing Liu   +11 more
doaj   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

δ-Tocotrienol (DT3) regulation of p27^Kip1 protein expression at the transcription level.

, 2013
A, MIAPaca-2 cells were treated with δ-tocotrienol at a predetermined IC50 and then with cyclohexamide to block protein synthesis. p27Kip1 turnover rate was examined by Western blot.
Kazim Husain (285140), Anying Zhang (170940), Mokenge P. Malafa (285152), Yanbin Dong (24525), Jose M. Pimiento (285141), Dung-Tsa Chen (285149), Domenico Coppola (53952), Rony Francois (285144), Jiandong Chen (220306), Said M. Sebti (251548), Pamela J. Hodul (285137), Warren J. Pledger (285146)   +11 more
core   +1 more source