Results 71 to 80 of about 201,244 (157)

δ-Tocotrienol suppresses pancreatic tumor growth in nude mice.

, 2013
A, nu/nu mice were injected subcutaneously with a suspension of MIAPaCa-2 cells (1×106) combined with Matrigel in both flanks. Tumor volume was recorded every other day according to the formula V  =  (l + w)/2 × (l × w) × 0.5236, where l is length and w ...
Kazim Husain (285140), Anying Zhang (170940), Mokenge P. Malafa (285152), Yanbin Dong (24525), Jose M. Pimiento (285141), Dung-Tsa Chen (285149), Domenico Coppola (53952), Rony Francois (285144), Jiandong Chen (220306), Said M. Sebti (251548), Pamela J. Hodul (285137), Warren J. Pledger (285146)   +11 more
core   +1 more source

Ferroptotic neurodegeneration and diet: a narrative review

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Dietary regimes and separate components have been reported to reduce ferroptosis by (1) altering iron metabolism, (2) increasing antioxidant defense, and (3) reducing lipid peroxidation. This ultimately leads to reduced ferroptosis and neurodegeneration.
Ximaine R. van der Burg, Danielle V. Toen, Scott Ayton, Hanno Pijl, Louise van der Weerd   +4 more
wiley   +1 more source

Abstract 222: Inhibition of cellular FLICE-inhibitory protein and induction of death receptor 5 expression is a major component of δ-tocotrienol-induced apoptosis in pancreatic cancer cells

, 2010
Background: Previous pre-clinical studies have demonstrated that δ-tocotrienol, is the most bioactive natural vitamin E compound against pancreatic cancer.
Rony A. Francois, Domenico Coppola, Said M. Sebti, Kazim Husain, Anying Zhang, Pamela J. Hodul, Mokenge P. Malafa, Steven C. Shivers   +7 more
core   +1 more source

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells

, 2008
The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of numerous growth-related proteins including nuclear lamins Ras and ...
Hussein, Deema
core   +4 more sources

Tocotrienols in Eleven Species of Hypericum Genus Leaves

Molecules
Saint John’s worts or goatweeds are mostly perennial flowering plants in the Hypericaceae family, formerly under the Clusiaceae family. Teas and macerations of the plants are common in traditional medicines and modern depression and cancer therapies. The
Danija Lazdiņa, Inga Mišina, Paweł Górnaś   +2 more
doaj   +1 more source

The Mechanism of Gut Microbiota in Breast Cancer Based on the Bulk Transcriptome, Mendelian Randomization Analysis and Single Cell RNA Sequencing

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This multi‐omics study defines the gut microbiota‐driven MCM6/NR3C1 axis as a key driver of breast cancer, providing robust biomarkers for early diagnosis and actionable therapeutic targets. ABSTRACT Breast cancer (BC) is the leading cause of cancer death in women.
Tianyu Luo, Mengyao Xue, Yi Du, Huiying Chen, Ying Sun, Haidong Sun   +5 more
wiley   +1 more source

Species- and Age-Dependent Prenyllipid Accumulation in Hypericum Species’ Leaves

Plants
Carotenoid, chlorophyll and tocochromanol biosynthesis and accumulation are interrelated and age-dependent in plants. Model plants produce tocopherols, but do not produce significant amounts of tocotrienols; consequently, the regulation of tocotrienol ...
Danija Lazdiņa, Ieva Miķelsone, Inga Mišina, Krists Dukurs, Ana M. Benítez-González, Carla M. Stinco, Antonio J. Meléndez-Martínez, Paweł Górnaś   +7 more
doaj   +1 more source

Oil/Water Biphasic Solvent System for the Eco-Extraction and Cosmetic Formulation of Bixa orellana L.

Plants
Annatto, obtained from the seeds of achiote (Bixa orellana L.), is a widely used orange pigment rich in bixin and other apocarotenoids. This work reports the optimisation of a green extraction method of pigments and antioxidant compounds from achiote as ...
Marine Chambaud, Ariane Fournier, Clément De Saint Jores, Benjamin Caux, Cyril Colas, Emilie Destandau   +5 more
doaj   +1 more source

Vitamin E δ-Tocotrienol Augments the Antitumor Activity of Gemcitabine and Suppresses Constitutive NF-κB Activation in Pancreatic Cancer

, 2011
The NF-κB transcription factor functions as a crucial regulator of cell survival and chemoresistance in pancreatic cancer. Recent studies suggest that tocotrienols, which are the unsaturated forms of vitamin E, are a promising class of anticancer ...
Marta Perez, Teruo Yamauchi, Rony A. Francois, Said M. Sebti, Kazim Husain, Mokenge P. Malafa   +5 more
core   +1 more source