Results 71 to 80 of about 201,597 (153)

δ-Tocotrienol suppresses pancreatic tumor growth in nude mice.

, 2013
A, nu/nu mice were injected subcutaneously with a suspension of MIAPaCa-2 cells (1×106) combined with Matrigel in both flanks. Tumor volume was recorded every other day according to the formula V  =  (l + w)/2 × (l × w) × 0.5236, where l is length and w ...
Kazim Husain (285140), Anying Zhang (170940), Mokenge P. Malafa (285152), Yanbin Dong (24525), Jose M. Pimiento (285141), Dung-Tsa Chen (285149), Domenico Coppola (53952), Rony Francois (285144), Jiandong Chen (220306), Said M. Sebti (251548), Pamela J. Hodul (285137), Warren J. Pledger (285146)   +11 more
core   +1 more source

Safflower (Carthamus tinctorius L.) Seed Oils: Effect of Extraction Process and Cultivars on Chemical Composition, Physicochemical Parameters and Nutritional Quality Index

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
M. pulegium essential oil study emphasizes molecular structure analysis and bioactivity. Chemical composition varies based on geographical origin. In silico analyses confirm binding affinities. Essential oil shows potent insecticidal activity with LD50 and LT50.
Chaimae El Kourchi, Oumayma Belhoussaine, Rim Mohammed Ali, Mohammed Amakhmakh, Khalid M. Sumaily, Agnese Santanatoglia, Filippo Maggi, Giovanni Caprioli, Abdelhakim Bouyahya, Mohamed Tabyaouı, Hicham Harhar   +10 more
wiley   +1 more source

Abstract 222: Inhibition of cellular FLICE-inhibitory protein and induction of death receptor 5 expression is a major component of δ-tocotrienol-induced apoptosis in pancreatic cancer cells

, 2010
Background: Previous pre-clinical studies have demonstrated that δ-tocotrienol, is the most bioactive natural vitamin E compound against pancreatic cancer.
Rony A. Francois, Domenico Coppola, Said M. Sebti, Kazim Husain, Anying Zhang, Pamela J. Hodul, Mokenge P. Malafa, Steven C. Shivers   +7 more
core   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells

, 2008
The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of numerous growth-related proteins including nuclear lamins Ras and ...
Hussein, Deema
core   +4 more sources

Tocotrienols in Eleven Species of Hypericum Genus Leaves

Molecules
Saint John’s worts or goatweeds are mostly perennial flowering plants in the Hypericaceae family, formerly under the Clusiaceae family. Teas and macerations of the plants are common in traditional medicines and modern depression and cancer therapies. The
Danija Lazdiņa, Inga Mišina, Paweł Górnaś   +2 more
doaj   +1 more source

Phytochemical Composition, Health Benefits, Functional Properties, and Food Applications of Pumpkin Seeds

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Pumpkin seeds (Cucurbita spp.) are rich in bioactive compounds including proteins, unsaturated fatty acids, dietary fiber, vitamins (E and B‐complex), minerals (zinc, magnesium, iron), and phytochemicals such as phenolics, flavonoids, and phytosterols.
Messenbet Geremew Kassa, Desye Alemu Teferi   +1 more
wiley   +1 more source

Species- and Age-Dependent Prenyllipid Accumulation in Hypericum Species’ Leaves

Plants
Carotenoid, chlorophyll and tocochromanol biosynthesis and accumulation are interrelated and age-dependent in plants. Model plants produce tocopherols, but do not produce significant amounts of tocotrienols; consequently, the regulation of tocotrienol ...
Danija Lazdiņa, Ieva Miķelsone, Inga Mišina, Krists Dukurs, Ana M. Benítez-González, Carla M. Stinco, Antonio J. Meléndez-Martínez, Paweł Górnaś   +7 more
doaj   +1 more source

Oil/Water Biphasic Solvent System for the Eco-Extraction and Cosmetic Formulation of Bixa orellana L.

Plants
Annatto, obtained from the seeds of achiote (Bixa orellana L.), is a widely used orange pigment rich in bixin and other apocarotenoids. This work reports the optimisation of a green extraction method of pigments and antioxidant compounds from achiote as ...
Marine Chambaud, Ariane Fournier, Clément De Saint Jores, Benjamin Caux, Cyril Colas, Emilie Destandau   +5 more
doaj   +1 more source

Vitamin E δ-Tocotrienol Augments the Antitumor Activity of Gemcitabine and Suppresses Constitutive NF-κB Activation in Pancreatic Cancer

, 2011
The NF-κB transcription factor functions as a crucial regulator of cell survival and chemoresistance in pancreatic cancer. Recent studies suggest that tocotrienols, which are the unsaturated forms of vitamin E, are a promising class of anticancer ...
Marta Perez, Teruo Yamauchi, Rony A. Francois, Said M. Sebti, Kazim Husain, Mokenge P. Malafa   +5 more
core   +1 more source