Tocotrienol-Dominated Berberidaceae Species’ Seed Tocochromanols: Screening via Ultrasound-Assisted Extraction in Ethanol [PDF]
PlantsInspired by the lack of wide-scale family level screenings, the profile of tocochromanols in Berberidaceae family species belonging to the Berberis, Mahonia, Caulophyllum, Jeffersonia and Podophyllum genera was studied. Seeds were acquired from botanical
Danija Lazdiņa +3 more
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Enhancing delta-tocotrienol production in Saccharomyces cerevisiae via metabolic engineering strategies in conjunction with the mutagenesis of tocopherol cyclase [PDF]
Synthetic and Systems BiotechnologyDelta (δ)-tocotrienol is a member of the vitamin E family and exhibits bioactivities such as antioxidant, anti-inflammatory, and neuroprotective activities.
Ziming Liu +7 more
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γ-Tocotrienol inhibition of galectin-3 expression, distribution and oligomerization in highly metastatic breast cancer cells [PDF]
Scientific ReportsExperimental studies were conducted to compare the relative effects of γ-tocotrienol, a natural isoform within the vitamin E family of compounds, with established galectin-3 inhibitor β-lactose, on galectin-3 levels and distribution in highly metastatic ...
Jessie J. Grazier, Paul W. Sylvester
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γ-Tocotrienol attenuates oxidative stress and preserves mitochondrial function in inflammation-induced muscle atrophy [PDF]
Redox BiologyMuscle atrophy, marked by the loss of skeletal muscle mass and strength, presents a major health concern with diverse etiologies, including chronic inflammation. Effective interventions are urgently needed for its prevention and treatment.
Jun Yi Chong +10 more
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Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA).
Kyoung-Woon Kim +6 more
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Effect of Tocotrienols Derived from Annatto on Lipid Profile and Some Adipokine Hormones in Rats Fed a High-Fat Diet [PDF]
Basrah Journal of Veterinary Research, 2023 Obesity is a metabolic condition that causes people to develop a variety of diseases and has emerged as a serious global public-health problem. Tocotrienol, a member of the vitamin E family that comes from the annatto bean (Bixa orellana), is special in ...
Eman Rahi, Nameer Khudhair
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Frontiers in Pharmacology, 2021 Osteoporosis, the most common bone disease, is associated with compromised bone strength and increased risk of fracture. Previous studies have shown that oxidative stress contributes to the progression of osteoporosis.
Nurul ‘Izzah Ibrahim +7 more
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Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. [PDF]
PLoS ONE, 2013 Vitamin E δ-tocotrienol has been shown to have antitumor activity, but the precise molecular mechanism by which it inhibits the proliferation of cancer cells remains unclear.
Pamela J Hodul +11 more
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The Role of Tocotrienol in Arthritis Management—A Scoping Review of Literature
Pharmaceuticals, 2023 Arthritis is a cluster of diseases impacting joint health and causing immobility and morbidity in the elderly. Among the various forms of arthritis, osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common.
Hashwin Singh Tejpal Singh +4 more
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Molecules, 2022 Glucocorticoid-induced osteogenic dysfunction is the main pathologyical mechanism underlying the development of glucocorticoid-induced osteoporosis. Glucocorticoids promote adipogenic differentiation and osteoblast apoptosis through various pathways ...
Sophia Ogechi Ekeuku +5 more
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