Enhancing delta-tocotrienol production in Saccharomyces cerevisiae via metabolic engineering strategies in conjunction with the mutagenesis of tocopherol cyclase [PDF]
Synthetic and Systems BiotechnologyDelta (δ)-tocotrienol is a member of the vitamin E family and exhibits bioactivities such as antioxidant, anti-inflammatory, and neuroprotective activities.
Ziming Liu +7 more
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Tocotrienol-Dominated Berberidaceae Species’ Seed Tocochromanols: Screening via Ultrasound-Assisted Extraction in Ethanol [PDF]
PlantsInspired by the lack of wide-scale family level screenings, the profile of tocochromanols in Berberidaceae family species belonging to the Berberis, Mahonia, Caulophyllum, Jeffersonia and Podophyllum genera was studied. Seeds were acquired from botanical
Danija Lazdiņa +3 more
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A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing. [PDF]
J Integr Plant BiolFor a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Zhang R +7 more
europepmc +2 more sources
γ-Tocotrienol attenuates oxidative stress and preserves mitochondrial function in inflammation-induced muscle atrophy [PDF]
Redox BiologyMuscle atrophy, marked by the loss of skeletal muscle mass and strength, presents a major health concern with diverse etiologies, including chronic inflammation. Effective interventions are urgently needed for its prevention and treatment.
Jun Yi Chong +10 more
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Combined metabolic and enzymatic engineering for de novo biosynthesis of δ-tocotrienol in Yarrowia lipolytica [PDF]
Synthetic and Systems Biotechnologyδ-Tocotrienol, an isomer of vitamin E with anti-inflammatory, neuroprotective and anti-coronary arteriosclerosis properties, is widely used in health care, medicine and other fields. Microbial synthesis of δ-tocotrienol offers significant advantages over
Jinbo Xiang +5 more
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The biological effects of tocotrienol on bone: a review on evidence from rodent models
Drug Design, Development and Therapy, 2015 Kok-Yong Chin, Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia Abstract: Osteoporosis causes significant health care and economic burden to society, leading to
Chin KY, Ima-Nirwana S
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Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA).
Kyoung-Woon Kim +6 more
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The Professional Medical Journal, 2012 Objective: To evaluate the effect of tocotrienols on intimal thickening in ascending aorta of cholesterol-fed rabbits. StudyDesign: Randomized control trial. Place and duration of study: The Anatomy department of Army Medical College, Rawalpindi, from March2009 to February 2010.
Uzma SHAHID +2 more
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Effect of Tocotrienols Derived from Annatto on Lipid Profile and Some Adipokine Hormones in Rats Fed a High-Fat Diet [PDF]
Basrah Journal of Veterinary Research, 2023 Obesity is a metabolic condition that causes people to develop a variety of diseases and has emerged as a serious global public-health problem. Tocotrienol, a member of the vitamin E family that comes from the annatto bean (Bixa orellana), is special in ...
Eman Rahi, Nameer Khudhair
doaj +1 more source
Frontiers in Pharmacology, 2021 Osteoporosis, the most common bone disease, is associated with compromised bone strength and increased risk of fracture. Previous studies have shown that oxidative stress contributes to the progression of osteoporosis.
Nurul ‘Izzah Ibrahim +7 more
doaj +1 more source