Results 1 to 10 of about 4,881 (175)

Combined metabolic and enzymatic engineering for de novo biosynthesis of δ-tocotrienol in Yarrowia lipolytica [PDF]

Synthetic and Systems Biotechnology
δ-Tocotrienol, an isomer of vitamin E with anti-inflammatory, neuroprotective and anti-coronary arteriosclerosis properties, is widely used in health care, medicine and other fields. Microbial synthesis of δ-tocotrienol offers significant advantages over
Jinbo Xiang, Mengsu Liu, Xinglong Wang, Mingyu Yue, Zhijie Qin, Jingwen Zhou   +5 more
doaj   +2 more sources

δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis [PDF]

Cell Death Discovery, 2023
Wound healing is a complex physiological process for maintaining skin integrity after a wound. Bone marrow-derived mesenchymal stem cells (BMSCs) are excellent cellular candidates for wound healing, which could be enhanced by exogenous stimulation.
Xiao He, Dawei Wang, Yi Yi, Yufang Tan, Min Wu, Haiping Wang, Weijie Hu, Hongbo Chen, Qi Zhang, Yiping Wu   +9 more
doaj   +2 more sources

δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients [PDF]

Lipids in Health and Disease, 2018
Background δ-Tocotrienol is a naturally occurring proteasome inhibitor, which has the capacity to inhibit proliferation and induce apoptosis in several cancer cells obtained from several organs of humans, and other cancer cell lines. Moreover, results of
Asaf A. Qureshi, Dilshad A. Khan, Shahida Mushtaq, Shui Qing Ye, Min Xiong, Nilofer Qureshi   +5 more
doaj   +2 more sources

Enhancing delta-tocotrienol production in Saccharomyces cerevisiae via metabolic engineering strategies in conjunction with the mutagenesis of tocopherol cyclase [PDF]

Synthetic and Systems Biotechnology
Delta (δ)-tocotrienol is a member of the vitamin E family and exhibits bioactivities such as antioxidant, anti-inflammatory, and neuroprotective activities.
Ziming Liu, Min Tang, Wanze Zhang, Yanjie Tian, Jianjun Qiao, Mingzhang Wen, Weiguo Li, Qinggele Caiyin   +7 more
doaj   +2 more sources

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs [PDF]

Cancer Cell International, 2019
Background Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects. Methods We report a novel function of VEDT in augmenting
Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa   +9 more
doaj   +2 more sources

Ca²⁺ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells. [PDF]

Apoptosis, 2021
Melanoma is an aggressive tumor with still poor therapy outcomes. delta-tocotrienol (delta-TT) is a vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated that delta-TT triggers apoptosis in human melanoma cells. Here,
Raimondi M, Fontana F, Marzagalli M, Audano M, Beretta G, Procacci P, Sartori P, Mitro N, Limonta P.   +8 more
europepmc   +3 more sources

β-Tocotrienol and δ-Tocotrienol as Additional Inhibitors of the Main Protease of Feline Infectious Peritonitis Virus: An In Silico Analysis [PDF]

Veterinary Sciences
Feline infectious peritonitis (FIP) is a severe and invariably fatal disease affecting both domestic and wild felines with limited effective therapeutic options available.
Manos C. Vlasiou, Georgios Nikolaou, Kyriakos Spanoudes, Daphne E. Mavrides   +3 more
doaj   +2 more sources

Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice [PDF]

Lipids in Health and Disease, 2010
Background Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated.
Morrison David C, Papasian Christopher J, Reis Julia C, Qureshi Asaf A, Qureshi Nilofer   +4 more
doaj   +5 more sources

δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of STAT3 pathway. [PDF]

PLoS ONE, 2015
Vitamin E intake has been implicated in reduction of bladder cancer risk. However, the mechanisms remain elusive. Here we reported that δ-tocotrienol (δ-T3), one of vitamin E isomers, possessed the most potent cytotoxic capacity against human bladder ...
Changxiao Ye, Wei Zhao, Minghui Li, Junlong Zhuang, Xiang Yan, Qun Lu, Cunjie Chang, Xiaojing Huang, Ji Zhou, Bingxian Xie, Zhen Zhang, Xin Yao, Jun Yan, Hongqian Guo   +13 more
doaj   +2 more sources

δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages [PDF]

International Journal of Molecular Sciences, 2018
Tao Yang, Limin Shi, Tao Hu
exaly   +2 more sources