Results 11 to 20 of about 4,881 (175)

Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. [PDF]

PLoS ONE, 2013
Vitamin E δ-tocotrienol has been shown to have antitumor activity, but the precise molecular mechanism by which it inhibits the proliferation of cancer cells remains unclear.
Pamela J Hodul, Yanbin Dong, Kazim Husain, Jose M Pimiento, Jiandong Chen, Anying Zhang, Rony Francois, Warren J Pledger, Domenico Coppola, Said M Sebti, Dung-Tsa Chen, Mokenge P Malafa   +11 more
doaj   +1 more source

Comparison of delta-tocotrienol and alpha-tocopherol effects on hepatic steatosis and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: A randomized double-blind active-controlled trial

Complementary Therapies in Medicine, 2022
Objective: We aimed to compare the efficacy of δ-tocotrienol with α-tocopherol in the treatment of patients with non-alcoholic fatty liver disease (NAFLD). Design and interventions: This study was a double-blinded, active-controlled trial.
Muhammad Amjad Pervez, Dilshad Ahmed Khan, Shakeel Ahmed Mirza, Atiq Ur Rehman Slehria, Uzma Nisar, Mohammad Aamir   +5 more
doaj   +1 more source

A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing. [PDF]

J Integr Plant Biol
For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Zhang R, Ren Y, Zhao Y, Zheng H, Luo Y, Liu Y, Wang L, Zhang L.   +7 more
europepmc   +2 more sources

Potentiation of in vitro apoptotic effects of δ-Tocotrienol and Jerantinine A on human lung adenocarcinoma cells [PDF]

Journal of HerbMed Pharmacology, 2019
Introduction: The apoptotic effects of single-compound and combined sub-effective concentrations of δ-tocotrienol and jerantinine A on human lung adenocarcinoma (A549) cells were investigated.
Ibrahim Babangida Abubakar, Hwei-San Loh
doaj   +1 more source

Vitamin A and E Homologues Impacting the Fate of Acrylamide in Equimolar Asparagine-Glucose Model System

Antioxidants, 2021
This study aims to evaluate the influence of Vitamin A and E homologues toward acrylamide in equimolar asparagine-glucose model system. Vitamin A homologue as β-carotene (BC) and five Vitamin E homologues, i.e., α-tocopherol (AT), δ-tocopherol (DT), α ...
Su Lee Kuek, Azmil Haizam Ahmad Tarmizi, Raznim Arni Abd Razak, Selamat Jinap, Maimunah Sanny   +4 more
doaj   +1 more source

Bioaccessibility of Tocols in Commercial Maize Hybrids Determined by an In Vitro Digestion Model for Poultry

Molecules, 2023
Despite the high proportion of maize grain in animal diets, the contribution made by maize phytochemicals is neglected. Tocols and their contribution to the vitamin E content of animal diets are one example, exacerbated by sparse information on the tocol
Veronika Gunjević, Dora Zurak, Darko Grbeša, Goran Kiš, Tatjana Međimurec, Vasil Pirgozliev, Kristina Kljak   +6 more
doaj   +1 more source

Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer:A randomized, double-blind, placebo-controlled phase II study [PDF]

, 2023
Purpose: Triplet chemotherapy might be more effective than doublet chemotherapy in metastatic colorectal cancer (mCRC), but it may also be marked by increased toxicity.
Brenner Thomsen, Caroline Emilie, Hansen, Torben Frøstrup, Havelund, Birgitte Mayland, Jensen, Lars Henrik, Lindebjerg, Jan, Rafaelsen, Søren, Raunkilde, Louise   +6 more
core   +1 more source

EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells [PDF]

Journal of Nutritional Biochemistry, 2015
Zhongsheng Tong, Mokenge P Malafa
exaly   +2 more sources

Radioprotective role of α-tocotrienol against oxidative damage in γ-irradiated human blood cultures

Bioscience Journal, 2018
Tocotrienols are members of the natural vitamin E family which is considered one of important fat soluble vitamins. The tocotrienols react with free radicals, which are the main cause of oxidation damage to cell membranes, without formation of other free radicals in the process.
Ahmed, Mahmoud Mohamed, Montaser, Sherien Abdelwahab, Mohamed, Manal Ramadan, Said, Zeinab Salem   +3 more
openaire   +5 more sources

δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling

Haematologica, 2010
Background Exposure to γ-radiation causes rapid hematopoietic cell apoptosis and bone marrow suppression. However, there are no approved radiation countermeasures for the acute radiation syndrome. In this study, we demonstrated that natural δ-tocotrienol,
Xiang Hong Li, Dadin Fu, Nabil H. Latif, Conor P. Mullaney, Patrick H. Ney, Steven R. Mog, Mark H. Whitnall, Venkataraman Srinivasan, Mang Xiao   +8 more
doaj   +1 more source