Results 21 to 30 of about 201,244 (157)

δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling

Haematologica, 2010
Background Exposure to γ-radiation causes rapid hematopoietic cell apoptosis and bone marrow suppression. However, there are no approved radiation countermeasures for the acute radiation syndrome. In this study, we demonstrated that natural δ-tocotrienol,
Xiang Hong Li, Dadin Fu, Nabil H. Latif, Conor P. Mullaney, Patrick H. Ney, Steven R. Mog, Mark H. Whitnall, Venkataraman Srinivasan, Mang Xiao   +8 more
doaj   +1 more source

Radioprotective role of α-tocotrienol against oxidative damage in γ-irradiated human blood cultures

Bioscience Journal, 2018
Tocotrienols are members of the natural vitamin E family which is considered one of important fat soluble vitamins. The tocotrienols react with free radicals, which are the main cause of oxidation damage to cell membranes, without formation of other free radicals in the process.
Ahmed, Mahmoud Mohamed, Montaser, Sherien Abdelwahab, Mohamed, Manal Ramadan, Said, Zeinab Salem   +3 more
openaire   +5 more sources

Efficient Secretory Production of δ‑Tocotrienol by Combining Pathway Modularization and Transportation Engineering

, 2023
The vitamin E component δ-tocotrienol has shown impressive activities in radioprotection, neuroprotection, and cholesterol reduction. Its production is limited by the low content in plants and difficulty in separation from other tocotrienols ...
Xue Jiao (461117), Taotao Feng (1920460), Qi Bian, Xiaomei Lyu (4284046), Xue Jiao, Taotao Feng, Hongwei Yu, Qi Bian (146193), Hongwei Yu (3139), Lidan Ye (2271958), Lidan Ye, Xiaomei Lyu   +11 more
core   +1 more source

δ-tocotrienol Inhibits Proliferation of Cervical Carcinoma Cells Through Upregulating MicroRNA-34a

Zhongliu Fangzhi Yanjiu, 2018
Objective To determine the effects of δ-tocotrienol on the proliferation of cervical carcinoma HeLa cells and whether miR-34a is involved in this process.
YU Ying, HUANG Jing, LI Rong, LIU Lianbin, WANG Qi, LUO Deping   +5 more
doaj   +1 more source

Effects of Delta-tocotrienol Supplementation on Liver Enzymes, Inflammation, Oxidative stress and Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease

The Turkish Journal of Gastroenterology, 2018
Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and is associated with increased morbidity and mortality. Currently, there is no definitive treatment for this disease.
Muhammad Amjad Pervez, Dishad Ahmet Khan, Aamir Ijaz, Shamrez Khan   +3 more
doaj   +1 more source

An Insight of Vitamin E as Neuroprotective Agents

Progress in Microbes and Molecular Biology, 2020
Nervous system is the network of nerve cells that transmits nerve impulses throughout the body. It is rich in both unsaturated fats and irons, making it predominantly susceptible to oxidative stress and damage.
Hui-Min Yap, Kwan-Liang Lye
doaj   +1 more source

Tocotrienols as an Anti-Breast Cancer Agent

Antioxidants, 2021
In the past few years, breast cancer has become the most prevalent type of cancer. The majority of patients receive combinatorial chemotherapy treatments, which may result in increased risk of developing drug resistance, a reduced quality of life, and ...
Madison Trujillo, Anupreet Kharbanda, Christa Corley, Pilar Simmons, Antiño R. Allen   +4 more
doaj   +1 more source

Novel approach to mitigate radiation overexposure, α-, δ-Tocotrienol as radiation mitigator: A case report

Journal of Radiation and Cancer Research, 2020
Background: Usage of radioactive sources for various medical and industrial purposes is very popular globally. Despite various technical advances, radiation accidents do occur due to lack of adequate expertise and regulatory control.
Anuradha Singh, Nagraj G Huilgol, Aditya Kaushik   +2 more
doaj   +1 more source

Proteasome inhibitors modulate anticancer and anti-proliferative properties via NF-kB signaling, and ubiquitin-proteasome pathways in cancer cell lines of different organs

Lipids in Health and Disease, 2018
Background Cancer is second most common cause of death in the United State. There are over 100 different types of cancer associated with different human organs, predominantly breast, liver, pancreas, prostate, colon, rectum, lung, and stomach.
Asaf A. Qureshi, Eleanor G. Zuvanich, Dilshad A. Khan, Shahida Mushtaq, Neerupma Silswal, Nilofer Qureshi   +5 more
doaj   +1 more source

The Effect of Pressure and Solvent on the Supercritical Fluid Chromatography Separation of Tocol Analogs in Palm Oil

Molecules, 2017
There are six tocol analogs present in palm oil, namely α-tocopherol (α-T), α-tocomonoenol (α-T1), α-tocotrienol (α-T3), γ-tocotrienol (γ-T3), β-tocotrioenol (β-T3) and δ-tocotrienol (δ-T3).
Mei Han Ng, Ahmad Kushairi
doaj   +1 more source