Results 21 to 30 of about 22,121 (219)

Tocotrienol as a Protecting Agent against Glucocorticoid-Induced Osteoporosis: A Mini Review of Potential Mechanisms

Molecules, 2022
Glucocorticoid-induced osteogenic dysfunction is the main pathologyical mechanism underlying the development of glucocorticoid-induced osteoporosis. Glucocorticoids promote adipogenic differentiation and osteoblast apoptosis through various pathways ...
Sophia Ogechi Ekeuku, Elvy Suhana Mohd Ramli, Norfarahin Abdullah Sani, Norzana Abd Ghafar, Ima Nirwana Soelaiman, Kok-Yong Chin   +5 more
doaj   +1 more source

The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats

Clinics, 2009
OBJECTIVE: This study examined the effects of palm oil tocotrienol-rich fractions on streptozotocin-induced diabetic rats. METHODS: Animals were divided into three groups: (i) normal non-diabetic (NDM), (ii) diabetic treated (tocotrienol-rich fractions -
Siti Balkis Budin, Faizah Othman, Santhana Raj Louis, Mokhtar Abu Bakar, Srijit Das, Jamaludin Mohamed   +5 more
doaj   +1 more source

Strategies to Enhance the Solubility and Bioavailability of Tocotrienols Using Self-Emulsifying Drug Delivery System

Pharmaceuticals, 2023
Tocotrienols have higher medicinal value, with multiple sources of evidence showing their biological properties as antioxidant, anti-inflammatory, and osteoprotective compounds.
Nur-Vaizura Mohamad
doaj   +1 more source

Metabolic engineering of micronutrients in crop plants [PDF]

, 2016
Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter, De Steur, Hans, Gellynck, Xavier, Van Der Straeten, Dominique   +3 more
core   +2 more sources

δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling

Haematologica, 2010
Background Exposure to γ-radiation causes rapid hematopoietic cell apoptosis and bone marrow suppression. However, there are no approved radiation countermeasures for the acute radiation syndrome. In this study, we demonstrated that natural δ-tocotrienol,
Xiang Hong Li, Dadin Fu, Nabil H. Latif, Conor P. Mullaney, Patrick H. Ney, Steven R. Mog, Mark H. Whitnall, Venkataraman Srinivasan, Mang Xiao   +8 more
doaj   +1 more source

TOCOTRIENOL DEMONSTRA POTENTE ATIVIDADE ANTINEOPLÁSICA NO MICROAMBIENTE TUMORAL

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: A leucemia mieloide aguda (LMA) é uma doença sistêmica que continua sendo um grave problema médico em todo o mundo. O acúmulo de células leucêmicas na medula óssea, leva a supressão da hematopoiese normal e promove processos inflamatórios que ...
MLP Bueno, I Santos, NG Amôr, ADS Santos, A Bastos, KP Ferro, STO Saad, FM Roversi   +7 more
doaj   +1 more source

Gamma-Tocotrienol Stimulates the Proliferation, Differentiation, and Mineralization in Osteoblastic MC3T3-E1 Cells

Journal of Chemistry, 2018
Gamma-tocotrienol, a major component of tocotrienol-rich fraction of palm oil, has been suggested to exhibit bone protective effects in vivo. However, the effects of γ-tocotrienol on osteoblast cells are still unclear.
Weili Xu, Pan He, Shenghua He, Pengju Cui, Yaqing Mi, Yang Yang, Yang Li, Shaobo Zhou   +7 more
doaj   +1 more source

Tocotrienols: Vitamin E beyond tocopherols [PDF]

Life Sciences, 2006
In nature, eight substances have been found to have vitamin E activity: alpha-, beta-, gamma- and delta-tocopherol; and alpha-, beta-, gamma- and delta-tocotrienol. Yet, of all papers on vitamin E listed in PubMed less than 1% relate to tocotrienols.
Chandan K, Sen, Savita, Khanna, Sashwati, Roy   +2 more
openaire   +2 more sources

Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]

, 2016
Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A., De Luca, C., Korkina, L., Ozben, T., Saso, Luciano   +4 more
core   +3 more sources

Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice [PDF]

, 2010
Background Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated.
Asaf A Qureshi, Julia C Reis, Christopher J Papasian, David C Morrison, Nilofer Qureshi   +4 more
core   +3 more sources