γ-Tocotrienol Inhibits Proliferation and Induces Apoptosis via the Mitochondrial Pathway in Human Cervical Cancer HeLa Cells [PDF]
Molecules, 2017 γ-Tocotrienol, a kind of isoprenoid phytochemical, has antitumor activity. However, there is limited evidence that it has an effect on cervical cancer.
Weili Xu +4 more
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γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells. [PDF]
PLoS ONE, 2013 Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to
Jing-Shu Zhang +8 more
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Tocotrienol-Dominated Berberidaceae Species’ Seed Tocochromanols: Screening via Ultrasound-Assisted Extraction in Ethanol [PDF]
PlantsInspired by the lack of wide-scale family level screenings, the profile of tocochromanols in Berberidaceae family species belonging to the Berberis, Mahonia, Caulophyllum, Jeffersonia and Podophyllum genera was studied. Seeds were acquired from botanical
Danija Lazdiņa +3 more
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γ-Tocotrienol attenuates oxidative stress and preserves mitochondrial function in inflammation-induced muscle atrophy [PDF]
Redox BiologyMuscle atrophy, marked by the loss of skeletal muscle mass and strength, presents a major health concern with diverse etiologies, including chronic inflammation. Effective interventions are urgently needed for its prevention and treatment.
Jun Yi Chong +10 more
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γ-Tocotrienol inhibition of galectin-3 expression, distribution and oligomerization in highly metastatic breast cancer cells [PDF]
Scientific ReportsExperimental studies were conducted to compare the relative effects of γ-tocotrienol, a natural isoform within the vitamin E family of compounds, with established galectin-3 inhibitor β-lactose, on galectin-3 levels and distribution in highly metastatic ...
Jessie J. Grazier, Paul W. Sylvester
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γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway [PDF]
Hereditas, 2023 Background Gastric cancer is a common cause of death from cancer and an important global health care issue. Consequently, there is an urgent need to find new drugs and therapeutic targets for the treatment of gastric cancer.
Ling Xie, Juan Yan
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Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin [PDF]
International Journal of Pharmaceutics: XRice bran oil (RBO) is rich in antioxidants but the high lipophilicity and low concentration of key active components complicate its formulation for topical delivery.
Erga Syafitri +3 more
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Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes [PDF]
Journal of Lipid Research, 2016 The Nod-like receptor 3 (NLRP3) inflammasome is an intracellular sensor that sets off the innate immune system in response to microbial-derived and endogenous metabolic danger signals.
Yongeun Kim +5 more
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Taxonomy—Dependent Seed Tocochromanol Composition in the Rutaceae Family: Application of Sustainable Approach for Their Extraction [PDF]
PlantsSeveral members of the Rutaceae (citrus) family are widely cultivated and processed. Tocopherol (T) synthesis and composition are well-documented, while tocotrienols (T3) in most plant families remain underreported.
Danija Lazdiņa +3 more
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Biochemistry and Biophysics Reports, 2021 One of the neuropathological hallmarks of Alzheimer's disease (AD)—causing neurodegeneration and consequent memory deterioration, and eventually, cognitive decline—is amyloid-β (Aβ) aggregation forming amyloid plaques.
Nor Faeizah Ibrahim +6 more
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