γ-Tocotrienol Sensitises Colorectal Cancer to PD-1 Blockade by Enhancing MHC-I-Associated Tumour Immune Visibility and CD8+ T Cell-Related Antitumour Immunity [PDF]
Biomoleculesγ-Tocotrienol (γ-T3), a naturally occurring vitamin E isoform from plant-derived sources, has attracted attention as an antitumour agent. However, whether γ-T3 can enhance antitumour immunity and improve immune checkpoint blockade remains unclear.
Haixia Wang +4 more
doaj +2 more sources
Characterization of Powdered Roasted Açaí Seeds (Euterpe oleracea Mart.): Impact on Bioactive Compounds and Nutritional Potential [PDF]
Food Sci NutrRoasting enhanced the functional potential of açaí (Euterpe oleracea Mart.) seeds, yielding a fiber‐rich powder with relevant minerals and bioactive compounds. Both lipid and aqueous extracts showed high phenolic contents and antioxidant activity, while the lipid fraction provided vitamin E‐active compounds and valuable fatty acids.
da Silva Magalhães R +9 more
europepmc +2 more sources
Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes [PDF]
Journal of Lipid Research, 2016 The Nod-like receptor 3 (NLRP3) inflammasome is an intracellular sensor that sets off the innate immune system in response to microbial-derived and endogenous metabolic danger signals.
Yongeun Kim +5 more
doaj +2 more sources
Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection. [PDF]
Int J Mol Sci, 2016 The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of ...
Ledet GA +8 more
europepmc +2 more sources
Delivery of the vitamin E compound tocotrienol to cancer cells [PDF]
, 2011 Tocotrienol, a member of the vitamin E family of compounds, is currently receiving increased attention because of its highly promising anti-cancer effects.
Dufès, Christine
core +3 more sources
γ-Tocotrienol Prevents Oxidative Stress-Induced Telomere Shortening in Human Fibroblasts Derived from Different Aged Individuals [PDF]
, 2010 The effects of palm γ-tocotrienol (GGT) on oxidative stress-induced cellular ageing was investigated in normal human skin fibroblast cell lines derived from different age groups; young (21-year-old, YF), middle (40-year-old, MF) and old (68-year-old, OF).
Azrina Zainal Abidin +5 more
core +1 more source
Loss of Vitamin E While Baking and Heating French Fries
Applied Sciences, 2023 Vitamin E, as the most important lipophilic antioxidant of eukaryotic cells, plays an important role in human nutrition. So far, information has focused on the content of vitamin E in raw food materials or foods, and its losses under various processes ...
Vojtech Ilko +7 more
doaj +1 more source
Antioxidants, 2014 Changes in antioxidant properties and degradation of bioactives in palm oil (PO) and rice bran oil (RBO) during deep-frying were investigated. The alpha (α)-tocopherol, gamma (γ)-tocotrienol and γ-oryzanol contents of the deep-fried oils were monitored ...
Azizah Abdul Hamid +4 more
doaj +1 more source
Γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway Through Inhibition of Receptor-Interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis [PDF]
, 2007 Unlike the tocopherols, the tocotrienols, also members of the vitamin E family, have an unsaturated isoprenoid side chain. In contrast to extensive studies on tocopherol, very little is known about tocotrienol.
Krishnan, Koyamangalath +3 more
core +1 more source
An Insight of Vitamin E as Neuroprotective Agents
Progress in Microbes and Molecular Biology, 2020 Nervous system is the network of nerve cells that transmits nerve impulses throughout the body. It is rich in both unsaturated fats and irons, making it predominantly susceptible to oxidative stress and damage.
Hui-Min Yap, Kwan-Liang Lye
doaj +1 more source