Results 41 to 50 of about 322,712 (165)

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Dynamic Changes in Vitamin E Biosynthesis during Germination in Brown Rice (Oryza sativa L.)

Foods, 2022
The present study investigated the dynamic changes in vitamin E and gene expression within its biosynthetic pathway during three germination periods of four brown rice cultivars with different seed coat colors.
Leilei Kong, Yingxin Lin, Jiayan Liang, Xiaodan Hu, Umair Ashraf, Xinbo Guo, Song Bai   +6 more
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Genotype and Environment Effects on Tocopherol, Tocotrienol, and γ‐Oryzanol Contents of Southern U.S. Rice

, 2003
Rice bran contains phytochemicals such as E vitamers (i.e., tocopherols and tocotrienols) and the γ-oryzanol fraction that reportedly may have positive effects on human health.
Z. Xu, Bergman, C. J., Xu, Z., C. J. Bergman   +3 more
core   +1 more source

Diet‐Related Differences Predominate Over Breed‐Associated Differences in Hepatic Lipid Metabolism, Antioxidant Vitamins and Lipid Quality Indices Among Beef Cattle

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Understanding how nutritional management and genetic background influence hepatic metabolism is important for improving the nutritional quality of bovine products in tropical production systems. This study evaluated breed‐associated differences under a common dietary regimen and diet‐related differences within the Nelore breed with respect to ...
Laíza de Kássia Mendes da Conceição, José de Brito Lourenço‐Júnior, Jamile Andréa Rodrigues da Silva, Leonel António Joaquim, Mariana Jucá Moraes, Thomaz Cyro Guimarães de Carvalho Rodrigues, Joana Inês Ferreira, Ana Maria Ramos Fontes, Maria Pinheiro Spínola, Érica Coutinho David, Antônio Vinicius Correa Barbosa, Bruno Cabral Soares, José António Mestre Prates   +12 more
wiley   +1 more source

γ-Tocotrienol Inhibits Neoplastic Mammary Epithelial Cell Proliferation by Decreasing Akt and Nuclear Factor κB Activity

, 2005
Tocotrienols, a subgroup within the vitamin E family of compounds, have been shown to display potent anticancer activity and inhibit preneoplastic and neoplastic mammary epithelial cell proliferation at treatment doses that have little or no effect on ...
Sumit J. Shah, Paul W. Sylvester
core   +1 more source

Bacterial production of poly-γ-glutamic acid and evaluation of its effect on the viability of probiotic microorganisms [PDF]

, 2012
A thesis submitted for the degree of Doctor of Philosophy By Aditya Bhat, MScPoly-γ-glutamic acid (γ-PGA) is a naturally occurring biopolymer made up of repeating units of glutamic acid and can be potentially used for multiple applications.
Bhat, Aditya
core   +3 more sources

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, Volume 159, Issue 7, Page 1735-1749, 1 October 2026.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Increases of Lipophilic Antioxidants and Anticancer Activity of Coix Seed Fermented by Monascus purpureus

Foods, 2021
Lipophilic tocols, γ-oryzanol, and coixenolide in coix seed before and after fermentation by Monascus purpureus were determined. Antioxidant and anticancer activities of raw and fermented coix seed were evaluated using free-radical-scavenging assays and ...
Haiying Zeng, Likang Qin, Xiaoyan Liu, Song Miao   +3 more
doaj   +1 more source

Amelioration of Cancer Cachexia‐Induced Muscle Atrophy and Adipose Tissue Wasting by a Combination of Amaranth (Amaranthus caudatus L.) Hydrolysate and Korean Mint (Agastache rugosa) Extract in BALB/c Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Amaranth hydrolysate combined with Agastache rugosa extract (AKE) attenuated cancer cachexia in CT26 tumor‐bearing mice by suppressing systemic inflammation and modulating muscle and adipose tissue metabolism. AKE inhibited FoxO3a‐mediated proteolysis while restoring PI3K/Akt/mTOR‐dependent protein synthesis in skeletal muscle.
Junhee Lee, Junhui Kang, Sungmin Han, Ho‐Tak Jung, Daedong Kim, Dong‐Woo Lee, Jae‐Kwan Hwang   +6 more
wiley   +1 more source