Synergistic Antiproliferative Effects of Combined γ-Tocotrienol and PPARγ Antagonist Treatment Are Mediated through PPARγ-Independent Mechanisms in Breast Cancer Cells [PDF]
PPAR Research, 2014 Previous findings showed that the anticancer effects of combined γ-tocotrienol and peroxisome proliferator activated receptor γ (PPARγ) antagonist treatment caused a large reduction in PPARγ expression.
Abhita Malaviya, Paul W. Sylvester
doaj +2 more sources
Gamma-Tocotrienol Stimulates the Proliferation, Differentiation, and Mineralization in Osteoblastic MC3T3-E1 Cells [PDF]
Journal of Chemistry, 2018 Gamma-tocotrienol, a major component of tocotrienol-rich fraction of palm oil, has been suggested to exhibit bone protective effects in vivo. However, the effects of γ-tocotrienol on osteoblast cells are still unclear.
Weili Xu +7 more
doaj +2 more sources
Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells [PDF]
International Journal of Breast Cancer, 2013 γ-Tocotrienol is a natural vitamin E that displays potent anticancer activity, and previous studies suggest that these effects involve alterations in PPARγ activity.
Abhita Malaviya, Paul W. Sylvester
doaj +2 more sources
BMC Cancer, 2010 Background Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated with suppression in ErbB receptor ...
Sylvester Paul W +2 more
doaj +2 more sources
Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection. [PDF]
Int J Mol Sci, 2016 The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of ...
Ledet GA +8 more
europepmc +2 more sources
Effect of γ-tocotrienol in counteracting oxidative stress and joint damage in collagen-induced arthritis in rats. [PDF]
Exp Ther Med, 2014 Tocotrienols exhibit a significant anti-inflammatory and antioxidant effect in numerous human diseases. However, the anti-inflammatory and antioxidant effects of tocotrienols in arthritic conditions are not well documented.
Radhakrishnan A +4 more
europepmc +2 more sources
Molecules, 2023 Despite the high proportion of maize grain in animal diets, the contribution made by maize phytochemicals is neglected. Tocols and their contribution to the vitamin E content of animal diets are one example, exacerbated by sparse information on the tocol
Veronika Gunjević +6 more
doaj +1 more source
Delivery of the vitamin E compound tocotrienol to cancer cells [PDF]
, 2011 Tocotrienol, a member of the vitamin E family of compounds, is currently receiving increased attention because of its highly promising anti-cancer effects.
Dufès, Christine
core +2 more sources
γ-Tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor
Journal of Lipid Research, 2003 2,7,8-Trimethyl-2-(β-carboxyethyl)-6-hydroxychroman (γ-CEHC), a metabolite of γ-tocopherol and γ-tocotrienol, was identified as a new endogenous natriuretic factor.
Hisako Saito +5 more
doaj +1 more source
INDUCED PRODUCTION OF α-TOCOTRIENOL BY CO-SUPPRESSION OF TOCOPHEROL CYCLASE GENE IN VEGETABLE CROPS [PDF]
American Journal of Biochemistry and Biotechnology, 2013 This study involves the induced production of α-tocotrienol by the co-suppression of tocopherol cyclase gene. The Tocopherol/tocotrienol Cyclase (TC) is a key enzyme involved in the biosynthesis of α-tocotrienol. The partial conserved cDNA of TC gene isolated from the oil palm (Elaeis guineensis) that shared greater than 75% sequence identity with TC ...
openaire +1 more source