γ-Tocotrienol Inhibits Proliferation and Induces Apoptosis via the Mitochondrial Pathway in Human Cervical Cancer HeLa Cells [PDF]
Molecules, 2017 γ-Tocotrienol, a kind of isoprenoid phytochemical, has antitumor activity. However, there is limited evidence that it has an effect on cervical cancer.
Weili Xu +4 more
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Tocotrienol-Dominated Berberidaceae Species’ Seed Tocochromanols: Screening via Ultrasound-Assisted Extraction in Ethanol [PDF]
PlantsInspired by the lack of wide-scale family level screenings, the profile of tocochromanols in Berberidaceae family species belonging to the Berberis, Mahonia, Caulophyllum, Jeffersonia and Podophyllum genera was studied. Seeds were acquired from botanical
Danija Lazdiņa +3 more
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γ-Tocotrienol attenuates oxidative stress and preserves mitochondrial function in inflammation-induced muscle atrophy [PDF]
Redox BiologyMuscle atrophy, marked by the loss of skeletal muscle mass and strength, presents a major health concern with diverse etiologies, including chronic inflammation. Effective interventions are urgently needed for its prevention and treatment.
Jun Yi Chong +10 more
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γ-Tocotrienol inhibition of galectin-3 expression, distribution and oligomerization in highly metastatic breast cancer cells [PDF]
Scientific ReportsExperimental studies were conducted to compare the relative effects of γ-tocotrienol, a natural isoform within the vitamin E family of compounds, with established galectin-3 inhibitor β-lactose, on galectin-3 levels and distribution in highly metastatic ...
Jessie J. Grazier, Paul W. Sylvester
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γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway [PDF]
Hereditas, 2023 Background Gastric cancer is a common cause of death from cancer and an important global health care issue. Consequently, there is an urgent need to find new drugs and therapeutic targets for the treatment of gastric cancer.
Ling Xie, Juan Yan
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Synergistic Antiproliferative Effects of Combined γ-Tocotrienol and PPARγ Antagonist Treatment Are Mediated through PPARγ-Independent Mechanisms in Breast Cancer Cells [PDF]
PPAR Research, 2014 Previous findings showed that the anticancer effects of combined γ-tocotrienol and peroxisome proliferator activated receptor γ (PPARγ) antagonist treatment caused a large reduction in PPARγ expression.
Abhita Malaviya, Paul W. Sylvester
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Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells [PDF]
International Journal of Breast Cancer, 2013 γ-Tocotrienol is a natural vitamin E that displays potent anticancer activity, and previous studies suggest that these effects involve alterations in PPARγ activity.
Abhita Malaviya, Paul W. Sylvester
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BMC Cancer, 2010 Background Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated with suppression in ErbB receptor ...
Sylvester Paul W +2 more
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Efficacy of Vitamin E Administration on Serum Lipid Profile in Adult Patients With Dyslipidemia: A GRADE‐Assessed Systematic Review and Dose–Response Meta‐Analysis of RCTs [PDF]
Food Sci NutrThe graphical abstract summarizes a GRADE‐assessed systematic review and dose–response meta‐analysis of 22 randomized controlled trials evaluating oral vitamin E supplementation in adults with dyslipidemia. It presents the effects on serum lipid parameters, including triglycerides (TG), total cholesterol (TC), LDL‐C, and HDL‐C.
Karimi M +7 more
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Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin [PDF]
International Journal of Pharmaceutics: XRice bran oil (RBO) is rich in antioxidants but the high lipophilicity and low concentration of key active components complicate its formulation for topical delivery.
Erga Syafitri +3 more
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