Ligand and G-protein selectivity in the κ-opioid receptor. [PDF]
Nature, 2023 The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective ...
Han J +13 more
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Central nicotine induces browning through hypothalamic κ opioid receptor [PDF]
Nature Communications, 2019 Nicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.
Patricia Seoane-Collazo +21 more
doaj +3 more sources
Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor [PDF]
Journal of Neuroinflammation, 2018 Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang +12 more
doaj +5 more sources
Opioids in cancer: The κ‑opioid receptor (Review). [PDF]
Mol Med Rep, 2022 The κ-opioid receptor (KOR) is one of the primary receptors of opioids and serves a vital role in the regulation of pain, anesthesia, addiction and other pathological and physiological processes.
Zhou Q +5 more
europepmc +2 more sources
Molecular Interaction Between Butorphanol and κ-Opioid Receptor. [PDF]
Anesth Analg, 2020 BACKGROUND: The misuse of opioids stems, in part, from inadequate knowledge of molecular interactions between opioids and opioid receptors. It is still unclear why some opioids are far more addictive than others.
Ji J +7 more
europepmc +2 more sources
Nalfurafine Hydrochloride, a κ-Opioid Receptor Agonist, Induces Melanophagy via PKA Inhibition in B16F1 Cells [PDF]
Cells, 2022 Selective autophagy controls cellular homeostasis by degrading unnecessary or damaged cellular components. Melanosomes are specialized organelles that regulate the biogenesis, storage, and transport of melanin in melanocytes.
Ha Jung Lee +13 more
doaj +2 more sources
The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations [PDF]
Frontiers in Molecular Neuroscience, 2022 Recent evidence has shown that G protein-coupled receptors (GPCRs) are direct sensors of the autophagic machinery and opioid receptors regulate neuronal plasticity and neurotransmission with an as yet unclarified mechanism.
Christos Karoussiotis +6 more
doaj +2 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: In a previous study, we showed that κ-opioid receptor stimulation with the selective agonist U50,488H ameliorated hypoxic pulmonary hypertension (HPH).
Yaguang Zhou +13 more
doaj +2 more sources
Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors [PDF]
Scientific Reports, 2023 Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders.
Soichiro Ide +4 more
doaj +2 more sources
G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons. [PDF]
Sci Signal, 2018 Triazole 1.1 is a G protein–biased agonist of the κ-opioid receptor in striatal neurons. Biasing pain treatment against side effects Stimulating opioid receptors with targeted agonists can treat pain, but such drugs often cause unwanted and even ...
Ho JH +5 more
europepmc +2 more sources