The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations [PDF]
Frontiers in Molecular Neuroscience, 2022 Recent evidence has shown that G protein-coupled receptors (GPCRs) are direct sensors of the autophagic machinery and opioid receptors regulate neuronal plasticity and neurotransmission with an as yet unclarified mechanism.
Christos Karoussiotis +6 more
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Κ-opioid receptor stimulation improves endothelial function in hypoxic pulmonary hypertension. [PDF]
PLoS ONE, 2013 The present study was designed to investigate the effect of κ-opioid receptor stimulation with U50,488H on endothelial function and underlying mechanism in rats with hypoxic pulmonary hypertension (HPH).
Qi Wu +11 more
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Nalfurafine Hydrochloride, a κ-Opioid Receptor Agonist, Induces Melanophagy via PKA Inhibition in B16F1 Cells [PDF]
Cells, 2022 Selective autophagy controls cellular homeostasis by degrading unnecessary or damaged cellular components. Melanosomes are specialized organelles that regulate the biogenesis, storage, and transport of melanin in melanocytes.
Ha Jung Lee +13 more
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Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors [PDF]
Scientific Reports, 2023 Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders.
Soichiro Ide +4 more
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Ligand and G-protein selectivity in the κ-opioid receptor. [PDF]
Nature, 2023 Han J +13 more
europepmc +3 more sources
Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects. [PDF]
Molecules, 2023 Santino F, Gentilucci L.
europepmc +3 more sources
Central δ/κ opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation [PDF]
The Journal of Reproduction and DevelopmentIn mammals, secretion of tonic (pulsatile) gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) is often suppressed during lactation. Suppression of GnRH/LH pulses in lactating dams is assumed to be caused by suckling stimuli and a chronic ...
Yoshihisa UENOYAMA +6 more
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Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development [PDF]
MoleculesThe opioid crisis in the United States is a significant public health issue, with a nearly threefold increase in opioid-related fatalities between 1999 and 2014. In response to this crisis, society has made numerous efforts to mitigate its impact. Recent
Zoe Li +11 more
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Central nicotine induces browning through hypothalamic κ opioid receptor [PDF]
Nature Communications, 2019 Nicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.
Patricia Seoane-Collazo +21 more
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Butorphanol alleviates lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes via activation of the κ-opioid receptor. [PDF]
Exp Ther Med, 2021 Tang W, Luo L, Hu B, Zheng M.
europepmc +3 more sources