Results 131 to 140 of about 62,533 (281)

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference [PDF]

, 2013
Stress increases the risk of drug abuse, causes relapse to drug seeking, and potentiates the rewarding properties of both nicotine and cocaine. Understanding the mechanisms by which stress regulates the rewarding properties of drugs of abuse provides ...
Al-Hasani, Ream, Bruchas, Michael R, McCall, Jordan G   +2 more
core   +2 more sources

The Cannabinoid System as a Potential Novel Target for Alcohol‐Associated Liver Disease: A Propensity‐Matched Cohort Study

Liver International, Volume 45, Issue 11, November 2025.
ABSTRACT Background Alcohol‐associated liver disease (ALD) is a leading cause of liver‐related morbidity and mortality, yet effective therapeutic options remain limited. Preclinical data suggest that modulation of the hepatic endocannabinoid system, particularly via cannabidiol (CBD), may reduce alcohol‐induced liver injury.
Butros Fakhoury, Vinay Jahagirdar, Kaanthi Rama, David Hudson, Wei Wang, Luis Antonio Díaz, Juan Pablo Arab   +6 more
wiley   +1 more source

Differential effects of K⁺ channel blockers on antinociception induced by α₂‐adrenoceptor, GABA_B and κ‐opioid receptor agonists [PDF]

, 1993
Maria Ocaña, José M. Baeyens
openalex   +1 more source

Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists*

Journal of Biological Chemistry, 2013
Background: The κ-opioid receptor can be activated by structurally diverse agonists. Results: Four structurally diverse agonists differentially bound to and activated wild type and mutant κ-opioid receptors.
Eyal Vardy, P. Mosier, K. Frankowski, Huixian Wu, V. Katritch, R. Westkaemper, J. Aubé, R. Stevens, B. Roth   +8 more
semanticscholar   +1 more source

On the role of G protein-coupled receptors oligomerization [PDF]

, 2013
The existence of a supramolecular organization of the G protein-coupled receptor (GPCR) is now being widely accepted by the scientific community.
Ahern, Siobhán, Ciruela Alférez, Francisco, Fernández Dueñas, Víctor, Gómer Soler, Maricel   +3 more
core   +2 more sources

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

The Journal of Physiology, Volume 603, Issue 21, Page 6473-6502, November 1, 2025.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia, Deborah Varro, Thomas Buffet, Olivier Marre   +3 more
wiley   +1 more source

Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity

Beilstein Journal of Organic Chemistry, 2013
The recent crystal structure of the κ-opioid receptor (κ-OR) revealed, unexpectedly, that the antagonist JDTic is a bivalent ligand: in addition to the orthosteric pocket occupied by morphinans, JDTic also occupies a distinct (allotopic) pocket ...
Thomas A. Munro, Wei Xu, Douglas M. Ho, Lee-Yuan Liu-Chen, Bruce M. Cohen   +4 more
doaj   +1 more source

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central
Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano Monteiro C. Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima   +4 more
doaj   +1 more source

Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. [PDF]

J Med Chem, 2023
Muratspahić E, White AM, Ciotu CI, Hochrainer N, Tomašević N, Koehbach J, Lewis RJ, Spetea M, Fischer MJM, Craik DJ, Gruber CW.   +10 more
europepmc   +1 more source