Results 131 to 140 of about 18,176 (269)

ABCB1, SLC22A1, COMT, and OPRM1 genotypes: Study of their influence on plasma methadone levels and clinical response to methadone maintenance treatment in opioid use disorder

Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.
Abstract Background Opioid use disorder (OUD) is an emerging and global public health concern, and its management remains inadequate, notably due to a lack of biomarkers, except for the CYP2B6 genetic polymorphisms. Objectives Hence, the aim of this study was to assess the influence of genetic polymorphisms of ABCB1, SLC22A1, COMT, and OPRM1 on ...
Abd El Kader Ait Tayeb, Edouard‐Jules Laforgue, Benoit Schreck, Marie Grall‐Bronnec, Jean‐Benoit Hardouin, Juliette Leboucher, OPAL Group, Caroline Victorri‐Vigneau, Céline Verstuyft   +8 more
wiley   +1 more source

Ingestion of amniotic fluid enhances the facilitative effect of VTA morphine on the onset of maternal behavior in virgin rats [PDF]

, 2009
Previous research has shown that injection of morphine into the ventral tegmental area(VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal ...
Daigler, Lindsey B., Hoey, Robert F., Kristal, Dr. Mark B., Neumann, Anne, Thompson, Dr. Alexis C.   +4 more
core  

Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implicationsCapsule Summary

JAAD International, 2022
Introduction: Treating chronic pruritus is challenging for dermatologists due to the lack of therapeutic options. We review the effects of κ-opioid receptor (KOR) and μ-opioid receptor (MOR) in the modulation of itch, summarize evidence supporting the ...
Sarina Elmariah, MD, PhD, Sarah Chisolm, MD, Thomas Sciascia, MD, Shawn G. Kwatra, MD   +3 more
doaj  

Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. [PDF]

J Med Chem, 2023
Muratspahić E, White AM, Ciotu CI, Hochrainer N, Tomašević N, Koehbach J, Lewis RJ, Spetea M, Fischer MJM, Craik DJ, Gruber CW.   +10 more
europepmc   +1 more source

Influence of Baseline Itch Severity on Treatment Outcomes With Difelikefalin in Adults With Moderate‐to‐Severe Pruritus Receiving Maintenance Haemodialysis: An Exploratory Analysis

Journal of Renal Care, Volume 51, Issue 2, June 2025.
ABSTRACT Background Difelikefalin is well‐tolerated and reduces itch among adults undergoing haemodialysis (HD), with chronic kidney disease‐associated pruritus (CKD‐aP). Objective This study aims to explore the influence of baseline itch severity on difelikefalin treatment outcomes.
Kieran McCafferty, Thilo Schaufler, Pablo Molina, Murray Lowe, Warren Wen, Daniel E. Weiner   +5 more
wiley   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. [PDF]

J Chem Inf Model, 2023
Salas-Estrada L, Provasi D, Qiu X, Kaniskan HÜ, Huang XP, DiBerto JF, Lamim Ribeiro JM, Jin J, Roth BL, Filizola M.   +9 more
europepmc   +1 more source

Anti‐Inflammatory Effects of Spexin on Acetic Acid‑Induced Colitis in Rats via Modulating the NF‐κB/NLRP3 Inflammasome Pathway

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 5, May 2025.
Spexin exhibits a therapeutic effect in ulcerative colitis. Spexin suppresses oxidative damage and neutrophil infiltration in the acetic acid induced ulcerative colitis rat model. Spexin reduces inflammation in ulcerative colitis by inhibiting the NLRP3 inflammasome pathway. Spexin suppresses the NF‐κB‐mediated increase in pro‐inflammatory cytokines in
Sevil Arabacı Tamer, Fadime Köse, Sevinç Yanar, Özcan Budak, Cahit Bağcı   +4 more
wiley   +1 more source

Differential effects of K⁺ channel blockers on antinociception induced by α₂‐adrenoceptor, GABA_B and κ‐opioid receptor agonists [PDF]

, 1993
Maria Ocaña, José M. Baeyens
openalex   +1 more source

Several factors predict the achievement of the patient acceptable symptom state and minimal clinically important difference for patient‐reported outcome measures following anterior cruciate ligament reconstruction: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 5, Page 1617-1632, May 2025.
Abstract Purpose To summarize the predictors of the patient acceptable symptom state (PASS), minimal clinically important difference (MCID) and minimal important change (MIC) for patient‐reported outcome measures (PROMs) following anterior cruciate ligament reconstruction (ACLR).
Bryan Sun, Prushoth Vivekanantha, Hassaan Abdel Khalik, Darren de SA   +3 more
wiley   +1 more source