Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor [PDF]
Journal of Neuroinflammation, 2018 Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang +12 more
doaj +4 more sources
Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [$^{35}$S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800 [PDF]
, 2022 In 2009, new synthetic opioids appeared on the new psychoactive substances market. This class of new psychoactive substances generally poses a health risk due to the high affinity and potency of most of these compounds for the opioid receptors.
Auwärter, V. +3 more
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Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco +8 more
wiley +1 more source
Analyzing Interaction of μ-, δ- and κ-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method [PDF]
Journal of Addiction Research & Therapy, 2012 Polymorphisms in the μ-, δ- and κ-opioid receptor genes (OPRM1, OPRD1 and OPRK1) have been reported to be associated with substance (alcohol or drug) dependence. The influence of an individual gene on a disease trait should be more evident when analyzed in the context of gene-gene interactions.
Zhong Li, Huiping Zhang
openaire +3 more sources
Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the κ‐Opioid Receptor [PDF]
, 2007 The clerodane diterpenoid salvinorin A ( 1 ), the main active component of the psychotropic herb Salvia divinorum , has been reported to be a potent agonist at the Κ -opioid receptor. Computer modeling suggested that splendidin ( 2 ) from S. splendens
Yiqiang Li +4 more
openalex +3 more sources
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]
PLoS ONE, 2014 Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang +10 more
doaj +1 more source
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance In recent years, the κ-opioid receptor (κOR) has become an attractive therapeutic target for the treatment of a number of disorders including depression, visceral pain, and drug addiction. A search for natural products with novel scaffolds targeting κOR has been intensive.
Achla Gupta +9 more
openaire +5 more sources
Molecules, 2021 Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa +12 more
doaj +1 more source
Frontiers in Medicine, 2022 BackgroundMyoclonic movement is a very common but undesirable phenomenon during the induction of general anesthesia using etomidate. Such movement may cause unnecessary problems.
Kang-Da Zhang +5 more
doaj +1 more source
Buprenorphine and methadone differentially alter early brain development in human cortical organoids. [PDF]
, 2023 Buprenorphine (BUP) and methadone (MTD) are used for medication-assisted treatment (MAT) in opioid use disorder. Although both medications show improved maternal and neonatal outcomes compared with illicit opioid use during pregnancy, BUP has exhibited ...
Gleeson, Joe +7 more
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