Cellular Physiology and Biochemistry, 2017 Background/Aims: In a previous study, we showed that κ-opioid receptor stimulation with the selective agonist U50,488H ameliorated hypoxic pulmonary hypertension (HPH).
Yaguang Zhou +13 more
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Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors [PDF]
Scientific Reports, 2023 Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders.
Soichiro Ide +4 more
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G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons. [PDF]
Sci Signal, 2018 Triazole 1.1 is a G protein–biased agonist of the κ-opioid receptor in striatal neurons. Biasing pain treatment against side effects Stimulating opioid receptors with targeted agonists can treat pain, but such drugs often cause unwanted and even ...
Ho JH +5 more
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Central δ/κ opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation [PDF]
The Journal of Reproduction and DevelopmentIn mammals, secretion of tonic (pulsatile) gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) is often suppressed during lactation. Suppression of GnRH/LH pulses in lactating dams is assumed to be caused by suckling stimuli and a chronic ...
Yoshihisa UENOYAMA +6 more
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Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development [PDF]
MoleculesThe opioid crisis in the United States is a significant public health issue, with a nearly threefold increase in opioid-related fatalities between 1999 and 2014. In response to this crisis, society has made numerous efforts to mitigate its impact. Recent
Zoe Li +11 more
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Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress. [PDF]
Acta Pharmacol Sin, 2022 Zan GY +10 more
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8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor [PDF]
Beilstein Journal of Organic Chemistry, 2007 There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds.
Thomas A. Munro +7 more
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Analyzing Interaction of μ-, δ- and κ-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method [PDF]
Journal of Addiction Research & Therapy, 2012 Polymorphisms in the μ-, δ- and κ-opioid receptor genes (OPRM1, OPRD1 and OPRK1) have been reported to be associated with substance (alcohol or drug) dependence. The influence of an individual gene on a disease trait should be more evident when analyzed in the context of gene-gene interactions.
Zhong Li, Huiping Zhang
openaire +3 more sources
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]
PLoS ONE, 2014 Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang +10 more
doaj +1 more source
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity [PDF]
Proceedings of the National Academy of Sciences, 2016 SignificanceIn recent years, the κ-opioid receptor (κOR) has become an attractive therapeutic target for the treatment of a number of disorders including depression, visceral pain, and drug addiction. A search for natural products with novel scaffolds targeting κOR has been intensive.
Achla Gupta +9 more
openaire +5 more sources