Results 11 to 20 of about 9,643 (193)

Butorphanol alleviates lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes via activation of the κ-opioid receptor. [PDF]

Exp Ther Med, 2021
Tang W, Luo L, Hu B, Zheng M.
europepmc   +3 more sources

Neuronal Colocalization of μ-Opioid Receptor, κ-Opioid Receptor, and Oxytocin Receptor mRNA in the Central Nucleus of the Amygdala in Male and Female Mice. [PDF]

eNeuro
Nisbett KE, Koob GF.
europepmc   +3 more sources

Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor. [PDF]

Front Pharmacol, 2021
Muratspahić E, Retzl B, Duerrauer L, Freissmuth M, Becker CFW, Gruber CW.   +5 more
europepmc   +3 more sources

Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]

PLoS ONE, 2014
Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang, Quan Fang, Zheng-lan Han, Jia-xin Pan, Xu-hui Li, Ning Li, Hong-hai Tang, Pei Wang, Ting Zheng, Xue-mei Chang, Rui Wang   +10 more
doaj   +1 more source

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

Molecules, 2021
Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa, Kanako Miyano, Hideaki Fujii, Takaaki Mizuguchi, Yui Kuroda, Miki Nonaka, Akane Komatsu, Kaori Ohshima, Masahiro Yamaguchi, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida   +12 more
doaj   +1 more source

Comparison of the Effectiveness of Various Drug Interventions to Prevent Etomidate-Induced Myoclonus: A Bayesian Network Meta-Analysis

Frontiers in Medicine, 2022
BackgroundMyoclonic movement is a very common but undesirable phenomenon during the induction of general anesthesia using etomidate. Such movement may cause unnecessary problems.
Kang-Da Zhang, Lin-Yu Wang, Dan-Xu Zhang, Zhi-Hua Zhang, Huan-Liang Wang, Huan-Liang Wang   +5 more
doaj   +1 more source

The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist. [PDF]

Proc Natl Acad Sci U S A, 2020
Mafi A, Kim SK, Goddard WA.
europepmc   +3 more sources

A Narrative Pharmacological Review of Buprenorphine: A Unique Opioid for the Treatment of Chronic Pain

Pain and Therapy, 2020
Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid receptor agonists.
Jeffrey Gudin, Jeffrey Fudin
doaj   +1 more source

Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord

Journal of Pharmacological Sciences, 2005
The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
doaj   +1 more source

Analyzing Interaction of μ-, δ- and κ-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method [PDF]

Journal of Addiction Research & Therapy, 2012
Background: Polymorphisms in the μ-, δ- and κ-opioid receptor genes (OPRM1, OPRD1 and OPRK1) have been reported to be associated with substance (alcohol or drug) dependence. The influence of an individual gene on a disease trait should be more evident when analyzed in the context of gene-gene interactions. Thus, we assessed the joint effect of variants
openaire   +1 more source