Results 31 to 40 of about 18,176 (269)
Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning. [PDF]
PLoS ONE, 2015 Opioid receptors (OR) are involved in myocardial late preconditioning (LPC) induced by morphine and δ1-opioid receptor (δ1-OR) agonists. The role of OR in ischemic-induced LPC is unknown.
Jan Fraessdorf +6 more
doaj +1 more source
Neurogastroenterology &Motility, Volume 34, Issue 12, December 2022., 2022 In women with IBS‐D, vibegron was not associated with significant improvement in the percentage of API weekly responders. Vibegron was generally safe and well tolerated and, in particular, did not worsen IBS symptoms vs. placebo. Abstract Background Preclinical and clinical studies suggest that β3‐adrenergic receptor activation may be a novel target ...
Brian E. Lacy +5 more
wiley +1 more source
Expressions and Distributions of Leucine-enkephalin, Delta, Mu, and Kappa Opioid Receptors in Four Systems of the Octopus, Octopus ocellatus by Comparative Immunohistochemical Method and ELISA [PDF]
, 2022 NO ABSTRACT AVAILABLEWe have investigated the expressions and distributions of leucine-enkephalin (Leu-enk), delta (δ), mu (μ), and kappa (κ) opioid receptors immunoreactivities in the respiratory, circulatory, excretory and reproductive systems of the ...
HAO, HY, SHA, AI
core +1 more source
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Antagonism of Opioid μ Receptors for Smoking Cessation [PDF]
, 2019 Opioid neurotransmission plays a role in rewarding process including the reinforcing actions of nicotine. In the past four decades, a great effort has been exercised to test the effectiveness of nonselective opioid antagonists (mainly naloxone and ...
Liu, Xiu
core +1 more source
Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]
, 2020 Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core +1 more source
Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands [PDF]
, 2013 Salvinorin A, the active ingredient of the hallucinogenic plant Salvia divinorum is the most potent known naturally occurring hallucinogen and is a selective κ-opioid receptor agonist.
Ferreira, Daneel +5 more
core +2 more sources
Frontiers in Immunology, 2020 Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang +5 more
doaj +1 more source
Large number of receptors may reduce cellular response time variation [PDF]
Physical biology 10 (3), 035008, 2013, 2012 Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv +1 more source
The discriminative effects of the κ-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects [PDF]
, 2010 RATIONALE: The widely available hallucinogen salvinorin A is a unique example of a plant-derived compound selective for κ-opioid receptors and may produce effects distinct from those of other compounds with classic hallucinogenic or dissociative ...
Butelman, Eduardo R. +3 more
core +1 more source