Results 81 to 90 of about 9,562 (190)

Potential use of early alterations in μ and δ opioid receptors as a predictive index for delayed brain ischemic damage

Neurobiology of Disease, 2003
We previously reported differential alterations of the μ, δ, and κ opioid receptors following permanent middle cerebral artery occlusion. The present work studied the evolution of opioid receptor types following transient focal cerebral ischemia (tMCAO),
Hervé Boutin, Philippe Jauzac, Eric T. MacKenzie, François Dauphin   +3 more
doaj   +1 more source

Unlocking the Antioxidant, Enzyme Inhibitory and Acaricidal Potential of Azadirachta indica Phytoconstituents Using In Vitro and In Silico Approaches

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
The study evaluated the acaricidal potential of bioactive components of Azadirachta indica against scabies mortality using both in vitro and in silico methodologies. Sarcoptes scabiei were stimulated with Azadirachta indica at four concentrations (25–100 mg/mL) at different intervals.
Tehreem Fatima, Mazhar Abbas, Kinza Zafar, Maha Gul Zafar, Waqas Haider, Muhammad Haseeb Zafar, Muhammad Riaz, Munawar Iqbal, Andrew G. Mtewa   +8 more
wiley   +1 more source

DAMGO, a μ‐opioid receptor selective ligand, distinguishes between μ‐and κ‐opioid receptors at a different region from that for the distinction between μ‐ and δ‐opioid receptors [PDF]

, 1995
Masabumi Minami, Tatsuhiro Onogi, Takayuki Nakagawa, Yoshikazu Katao, Yasuhide Aoki, Seishi Katsumata, Masamichi Satoh   +6 more
openalex   +1 more source

Nalfurafine is Aversive at Antinociceptive Doses in Mice

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Nalfurafine is the only clinically approved kappa opioid receptor (KOPr) agonist that can cross the blood–brain barrier and exert CNS effects. Because its clinical use is not associated with dysphoria, it is widely believed to have an atypical pharmacological profile.
E. J. Kuijer, L. H. Marinelli, S. J. Bailey, D. J. Heal, S. Smith, S. Wonnacott, C. P. Bailey   +6 more
wiley   +1 more source

Differential modulation of κ and μ opioid antinociception by the glycine/NMDA receptor agonist D‐serine [PDF]

, 1994
John C. Hunter, Paldeep S. Atwal, G.N. Woodruff, L. Singh   +3 more
openalex   +1 more source

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele, Patricia E. Kunze, Manuela L. Wieser, Annette P. N. Kutter   +3 more
wiley   +1 more source

Dopaminergic and Opioid Systems Interact to Produce Peripheral Antinociception in Mice

Journal of Integrative Neuroscience
Background: The overall pain experience results from the balance between the nociceptive pathway and the body’s endogenous modulation of nociception. The interaction of these systems reduces nociception.
Bárbara F. G. Queiroz, Walace C. P. Barra, Flávia C. S. Fonseca, Audrey L. Irie, Thiago R. L. Romero, Igor D. G. Duarte   +5 more
doaj   +1 more source

Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. [PDF]

J Med Chem, 2023
Muratspahić E, White AM, Ciotu CI, Hochrainer N, Tomašević N, Koehbach J, Lewis RJ, Spetea M, Fischer MJM, Craik DJ, Gruber CW.   +10 more
europepmc   +1 more source

A Review of Exercise Interventions for Rehabilitation in Drug‐Dependent Individuals

Addiction Biology, Volume 30, Issue 12, December 2025.
The analysis of 39 core studies indicates that diverse exercise interventions have varying positive effects across different dimensions for various addiction populations. Exercise can exert beneficial impacts on the neurobiological mechanisms, as well as physiological and psychological aspects, of individuals with drug addiction.
Qinghua He, Li Zhu, Zhaosong Wang, Hao Wang, Yiyi Jiang, Xin Wang, Fuxuan Luo, Chaoyi Zhu, Changlong Zhan   +8 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source