Results 81 to 90 of about 62,533 (281)

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors

Molecules, 2022
Accumulated preclinical and clinical data show that peripheral restricted opioids provide pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a potent dual μ-/δ-opioid receptor (MOR/DOR) full agonist, and a weak ...
Kristina Puls, Helmut Schmidhammer, Gerhard Wolber, Mariana Spetea   +3 more
doaj   +1 more source

Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]

, 2004
Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K., Ellenberger, E. A., Mueller, Janet L., Quock, Raymond M., Vaughn, Linda K.   +4 more
core   +1 more source

Molecular mechanisms underlying increased PDYN and dynorphin expression in the prefrontal cortex of alcoholic men [PDF]

, 2011
Alcohol dependence is a chronic relapsing disorder caused by drug x gene x environment interactions for which pharmacotherapy is but moderately effective.
Henriksson, Richard
core   +1 more source

Biomimetic Carbon‐Based Nanomaterials: From Design Strategies to Next‐Generation Biosensing and Theranostic Applications

Small, EarlyView.
This review summarizes biomimetic design strategies for carbon‐based nanomaterials, including graphene oxide, carbon dots, and nanotubes, highlighting their tunable physicochemical properties for advanced biosensing and theranostic systems. Defined approaches such as DNA templating, peptide‐assisted assembly, and fluorescence switching are discussed ...
Marzieh Ramezani Farani, Ashkan Zandi, Fatemeh Shojaeian, Mingzhen Zhang, Danial Khorsandi, Fariba Mollarasouli, Iraj Alipourfard, Amin Farahani, Yu Jung Choi, Heemin Kang, Yun Suk Huh   +10 more
wiley   +1 more source

A Novel Gβγ-Subunit Inhibitor Selectively Modulates μ-Opioid- Dependent Antinociception and Attenuates Acute Morphine-Induced Antinociceptive Tolerance and Dependence [PDF]

, 2008
The Gβγ subunit has been implicated in many downstream signaling events associated with opioids. We previously demonstrated that a small molecule inhibitor of Gβγ-subunit-dependent phospholipase (PLC) activation potentiated morphine-induced analgesia ...
Bidlack, Jean M, Mathews, Jennifer L, Smrcka, Alan V   +2 more
core   +2 more sources

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

Veterinary Record Case Reports, EarlyView.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele, Patricia E. Kunze, Manuela L. Wieser, Annette P. N. Kutter   +3 more
wiley   +1 more source

Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats.

PLoS ONE, 2014
Inflammation enhances the peripheral analgesic efficacy of opioid drugs, but the mechanisms involved in this phenomenon have not been fully elucidated. Crotalphine (CRP), a peptide that was first isolated from South American rattlesnake C.d.
Vanessa Olzon Zambelli, Ana Carolina de Oliveira Fernandes, Vanessa Pacciari Gutierrez, Julio Cesar Batista Ferreira, Carlos Amilcar Parada, Daria Mochly-Rosen, Yara Cury   +6 more
doaj   +1 more source

Synthesis and κ-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues

Journal of Medicinal Chemistry, 2014
The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for substance abuse.
Andrew P. Riley, Chad E Groer, David Young, A. Ewald, B. Kivell, T. Prisinzano   +5 more
semanticscholar   +1 more source

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
core   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source