Results 81 to 90 of about 9,643 (193)

Potential use of early alterations in μ and δ opioid receptors as a predictive index for delayed brain ischemic damage

Neurobiology of Disease, 2003
We previously reported differential alterations of the μ, δ, and κ opioid receptors following permanent middle cerebral artery occlusion. The present work studied the evolution of opioid receptor types following transient focal cerebral ischemia (tMCAO),
Hervé Boutin, Philippe Jauzac, Eric T. MacKenzie, François Dauphin   +3 more
doaj   +1 more source

Differential modulation of κ and μ opioid antinociception by the glycine/NMDA receptor agonist D‐serine [PDF]

, 1994
John C. Hunter, Paldeep S. Atwal, G.N. Woodruff, L. Singh   +3 more
openalex   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

DAMGO, a μ‐opioid receptor selective ligand, distinguishes between μ‐and κ‐opioid receptors at a different region from that for the distinction between μ‐ and δ‐opioid receptors [PDF]

, 1995
Masabumi Minami, Tatsuhiro Onogi, Takayuki Nakagawa, Yoshikazu Katao, Yasuhide Aoki, Seishi Katsumata, Masamichi Satoh   +6 more
openalex   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

The Effects of Bone‐Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX)

Cancer Medicine, Volume 15, Issue 1, January 2026.
In this retrospective population study containing 139,859 patients, subjects receiving RANK‐ligand inhibitors had improved survival and decreased rates of skeletal‐related events relative to the overall cohort of patients with metastatic bone lesions.
Brian H. Im, Kevin K. Zarrabi, Aaron R. Hochberg, Mihir S. Shah, James R. Mark, Joseph K. Izes, Patrick T. Gomella, Costas D. Lallas, Leonard G. Gomella, Adam R. Metwalli   +9 more
wiley   +1 more source

Dopaminergic and Opioid Systems Interact to Produce Peripheral Antinociception in Mice

Journal of Integrative Neuroscience
Background: The overall pain experience results from the balance between the nociceptive pathway and the body’s endogenous modulation of nociception. The interaction of these systems reduces nociception.
Bárbara F. G. Queiroz, Walace C. P. Barra, Flávia C. S. Fonseca, Audrey L. Irie, Thiago R. L. Romero, Igor D. G. Duarte   +5 more
doaj   +1 more source

Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats [PDF]

, 2015
Xuan Zhou, Dongjuan Wang, Yuyang Zhang, Jinxia Zhang, Dingcheng Xiang, Haichang Wang   +5 more
openalex   +1 more source

Oral Melatonin in Critically Ill Patients With COVID‐19: A Quasi‐Experimental Pragmatic Trial

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Melatonin has demonstrated antioxidant, anti‐inflammatory, and potential antiviral properties. Its therapeutic role in critically ill COVID‐19 patients admitted to intensive care was underexplored at the start of the pandemic. We conducted a quasi‐experimental, pragmatic study over 4 consecutive uninterrupted time periods alternating control ...
Miguel Sánchez‐García, Jesús A.F. Tresguerres, Manuel Álvarez‐González, Belén de la Hera, Virginia Puebla, Lidia Ybañez, José‐Manuel Martínez‐Sesmero, Antonio Blesa, Juan‐Carlos Martín‐Benítez, Fernando Martínez‐Sagasti, Paloma González‐Arenas, Sara Domingo, Cándido Pardo, Silmary Maichle, Carolina Postigo, Sara De‐Miguel, María Bringas, Raquel González‐Casanova, Viktor Yordanov, Alberto Delgado‐Iribarren, Esther Culebras, Miguel A. Armengol‐de la‐Hoz, Antonio Núñez‐Reiz   +22 more
wiley   +1 more source