Results 21 to 30 of about 22,762 (165)
Sfmbt2 10th intron hosted microRNA-669e-5p/3p promote cellular apoptosis by targeting anti-apoptotic gene Bcl2 [PDF]
, 2012 细胞凋亡是一个主动的由基因决定的自动结束生命的过程，对有机体的正常运行和体内稳态有重要作用。细胞凋亡一旦受到抑制，很可能导致肿瘤发生。然而，肿瘤发生发展过程中细胞凋亡调控的有关机制还不完全清楚。microRNAs（miRNAs）是一类非编码的小分子RNA，它们具有调节基因表达活性的功能，在细胞的各个进程（如细胞凋亡，分化和发育中）发挥着重要的作用。在肿瘤中miRNAs有可能通过调节与凋亡相关基因的表达，参与肿瘤细胞凋亡的调控。 miR-669e-5p和miR-669e ...
王涛
core
Veterinary Dermatology, Volume 37, Issue 1, Page 140-147, February 2026.Background: Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and may be aggravated by topical antiseptics. Hypothesis and Objectives: To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs
Adamantia Pseftogka +3 more
wiley +1 more source
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu +13 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2009 目的分析局部注射和肝动脉给予血管抑素基因（Angiostatin）和内皮抑素基因（Endostatin）重组质粒对大鼠肝癌治疗效果的差异。方法将肝癌模型大鼠随机分为:局部治疗组、局部对照组、肝动脉治疗组、肝动脉对照组。治疗组给予200μL质粒和脂质体复合物和对照组给予生理盐水200μL。治疗后观测肿瘤大小、微血管密度、血管内皮生长因子、肿瘤凋亡指标的变化。结果6d开始基因治疗组各治疗指标与对照组相比均具有统计学差异 ...
谢耀萍, 杨志杰, 李勇, 马铎
doaj
MK2 inhibitor selectively reduces alkali burn-induced inflammation and neovascularization in cornea [PDF]
, 2016 眼化学烧伤是一类常见的眼外伤疾病，特别是在发展中国家。与酸性烧伤相比，碱性烧伤更为常见。碱性物质可快速穿透眼前房，导致慢性炎症和角膜浑浊，从而导致严重且持久的视觉缺损。尽管角膜移植手术是一项有效的治疗方法，然而其成功与否取决于角膜的炎症和新生血管是否得到控制。尽管目前有许多用于治疗角膜炎症和新生血管的药物，然而由于其有一定的副作用或仅仅通过缓解症状而非从根本途径进行治疗，因此亟须从发病机制入手寻找新的治疗办法。 持久的角膜炎症与新生血管，不仅会导致永久的视觉缺失，还会使行角膜手术的时机推迟 ...
陈艳丰
core
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2008 目的探讨缺氧诱导因子（HIF-1α）基因治疗家兔肢体缺血模型的疗效。方法在家兔缺血模型的肢体内注射携带/HIF-1α基因的重组腺病毒AdHIF-1α,检测HIF-1α基因在缺血肌组织中表达情况,并观察其生物学特点。实验以携带GFP基因的重组腺病毒AdGFP为对照。结果免疫组化染色均检测到HIF-1α的表达。转AdHIF-1α基因治疗组毛细血管计数及小动脉计数均高于AdGFP转导的对照组 ...
孙晓峰 +5 more
doaj
Effects of ApoE Isoforms Expression on Brain ApoE Lipidation and Amyloid-β Accumulation [PDF]
, 2015 在编码人三种不同apoE蛋白亚型（E2、E3和E4）的APOE等位基因（ε2、ε3和ε4）中，APOEε4等位基因是阿尔茨海默病（Alzheimer’sdisease，AD）最重要的遗传风险因子，APOEε2等位基因则具有保护作用。鉴于apoE蛋白亚型对基于调节apoE蛋白表达的AD治疗可能会有不同的影响，我们通过在人APOE基因定位替换（Targetedreplacement，TR）小鼠脑中过表达不同的人apoE亚型，研究脑中表达不同apoE亚型对apoE脂化和β-淀粉样蛋白（Amyloid-β，Aβ）
胡进
core
USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2 [PDF]
, 2015 蛋白泛素化/去泛素化修饰的异常与多种肿瘤的发生存在密切相关。作为去泛素化酶家族中的重要一员,USP4在一些肺癌细胞及其它人类癌细胞中呈现出高表达，说明USP4可能作为癌蛋白(oncoprotein)参与到对肿瘤细胞发生发展的调控。而目前对USP4参与肿瘤细胞发生的分子机制尚不清楚。我们的前期研究发现，USP4可以与去乙酰基转移酶HDAC2结合。初步研究表明USP4可以去泛素化并稳定HDAC2。进一步的研究发现，USP4通过HDAC2抑制p53的转录活性及NF-κB信号通路。在本项申请中 ...
李增鹏
core +1 more source
Boron Difluoride Chelated Aminoanthraquinone Photosensitizer for Type I Photodynamic Therapy
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Type I photosensitizers capable of generating cytotoxic reactive oxygen species (ROS), with reduced oxygen dependence under photoirradiation, are regarded as a promising phototherapeutic approach for hypoxic solid tumors. Herein, based on the electron donor of 9‐phenyl‐carbazole (Cz) and the electron acceptor of anthraquinone (AQ ...
Tian Zhang +8 more
wiley +1 more source