Results 101 to 110 of about 12,568 (154)

[EVA1A overexpression improves non-alcoholic fatty liver disease in mice by regulating lipid metabolism and promoting lipophagy]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Xu J, Yang D, Zang K, Chu M, Zhao Q, Li Q, Lu S, Chen X, Li N.   +8 more
europepmc   +1 more source

[The role and molecular mechanism of transcription factor EB and its target genes in multiple myeloma treatment with bortezomib]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Zhang RJ, Wang ZL, Shi XM, Zhang SY, Wang W, Ma MS, Li C, Gu CH, Zhang ZH.   +8 more
europepmc   +1 more source

IRAK-4基因沉默对人成骨样细胞凋亡的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2013
【目的】研究siRNA沉默白细胞介素-1受体相关激酶-4(IRAK-4)基因对人成骨样细胞株MG63凋亡及凋亡相关基因Bcl-2、Bax表达的影响。【方法】 以Lipofectamine 2000为载体将IRAK-4-siRNA转染入MG63细胞(CON组:不加入任何转染试剂;SC组:以scrambled siRNA序列进行转染;KD组:以特异性IRAK-4-siRNA序列进行转染),应用流式细胞术及TUNEL法检测细胞凋亡水平,western blotting检测Bcl-2、Bax基因的表达。【结果】
doaj  

[PINK1 suppresses colorectal cancer cell growth through epigenetic regulation of histone modifications]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Wang M, Luan S, Fan X, Han D, Zhu Y.
europepmc   +1 more source

PTEN基因对子宫内膜癌细胞PI3K/AKT通路的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2011
【目的】探讨PTEN基因在子宫内膜癌PI3K/AKT通路中的作用，评估PTEN基因在抗肿瘤治疗中的意义。【方法】利用慢病毒载体系统, 构建人PTEN基因RNA干扰慢病毒载体和PTEN基因过表达慢病毒载体,分别转染PTEN野生型的HEC-1A细胞和PTEN突变型的Ishikawa细胞, 建立PTEN 基因敲减及过表达的细胞模型，Western Blot方法检测PTEN基因敲减或过表达前后PTEN蛋白的表达和AKT通路的活化情况, MTT法检测慢病毒转染前后细胞增殖的变化 ...
doaj  

[Neonatal-onset multisystem inflammatory disease in a neonate caused by a <i>de novo</i><i>NLRP3</i> variant]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Gao FH, Tang ZF, Song JW, Zhang WB, Yang L.   +4 more
europepmc   +1 more source

[Aerobic exercise regulates macrophage polarization and improves insulin resistance in mice: the mediating role of miR-221-3p]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Li N, Zhang L, Guo Q, Zhou Y, Liu C.
europepmc   +1 more source

["Chongqing experiences" in treatment of bone infections]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Xie Z.
europepmc   +1 more source

外源性SHIP基因表达抑制生长因子介导的 K562细胞增殖及Akt磷酸化

Zhongshan Daxue xuebao. Yixue kexue ban, 2009
【目的】 探讨SHIP基因对IL-3诱导K562细胞系增殖的抑制作用,阐明SHIP对K562细胞作用的机制65377;【方法】 将慢病毒质粒pReceiver-Lv31-FIV和pReceiver-Lv31-SHIP转染K562细胞;转染细胞与IL-3共培养,Western blot法检测K562细胞Akt磷酸化;观察转染野生型SHIP基因对K562细胞增殖的影响;末端脱氧核苷酸转移酶介导的dUTP缺失末端标记(TUNEL)法检测细胞凋亡65377;【结果】 重组慢病毒载体pReceiver-Lv31 ...
doaj  

[Effect of dephosphorylation of tumor metastasis suppressor gene <i>LASS2</i> on vacuolar ATPase activity and invasiveness of prostate cancer]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Liu Y, Lu M, Zhao X, Zhang K, Wu R, Mei F, Dai Z, You J, Pei F.   +8 more
europepmc   +1 more source