Results 11 to 20 of about 25,392 (169)
ABSTRACT The regeneration of osteoporotic bone defects is severely hampered by compromised endogenous healing capacity, demanding advanced strategies that actively orchestrate pro‐osteogenic microenvironments. Here, we report an integrated, self‐powered osteo‐regenerative system that uniquely leverages a dual ultrasound‐responsive piezoelectric ...
Bing Tan +6 more
wiley +1 more source
Uncovering correlates of decline and critical refuges for a threatened terrestrial mammal
Abstract Globally, the geographic ranges of numerous species are contracting. Identifying spatiotemporal patterns of threat impact can illuminate why species decline in some parts of their range but persist in others. We developed a correlative approach to identify species’ response thresholds and locate ecological refuge areas associated with ...
Natalya M. Maitz +5 more
wiley +1 more source
Abstract Urbanisation is reshaping how people experience wildlife, reducing our shared spaces with local biodiversity. Fewer opportunities for human–wildlife interactions weaken our emotional attachments to nature and precipitate a loss of species knowledge and familiarity.
Sam S. S. Lau +3 more
wiley +1 more source
ABSTRACT The pathogenesis of diabetic foot ulcers is complex, often involving polymicrobial infection and persistent inflammatory responses, which lead to delayed or nonhealing wounds, posing a formidable clinical challenge. Existing photodynamic therapy reagents and traditional treatments generally address only a single pathological aspect, and the ...
Yu Zhang +16 more
wiley +1 more source
ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma +6 more
wiley +1 more source
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
ABSTRACT Managing diabetic wounds requires simultaneously addressing their infectious, oxidative, and regenerative impairments. To address this, this study integrates a piezoelectric BiOCl@CuSe heterojunction (PFM‐verified) into an injectable F127/HA hydrogel, creating an ultrasound‐responsive smart dressing.
Jiayan Guo +5 more
wiley +1 more source
ABSTRACT The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is often limited, whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy. To address this challenge, this study developed a reactive oxygen species (ROS)‐responsive and mitochondria‐targeted nanomicelle (POM@CTT ...
Qingqing Dou +6 more
wiley +1 more source
Species composition of small mammals in Jinhua City(金华城区小型兽类种类组成)
1997年1月至1999年12月,选择金华城区的居民区、宾馆、粮库和工厂等4种生境5个调查点以夹夜法对常规灭鼠中小型兽类的种类组成进行了分析和研究.结果表明:金华城区共有臭鼩鼱(Suncus murinus)、褐家鼠(Rattus norvegicus)、黄胸鼠(Rattus flavipectus)、小家鼠(Mus musculus)和黑线姬鼠(Apodemus agrarms)等5种小型兽类;种类组成呈现以褐家鼠为主,臭鼩鼱和黑线姬鼠为次,黄胸鼠和小家鼠较少的格局 ...
BAOYi-xin(鲍毅新) +3 more
doaj +1 more source
目的观察肝原位瘤切除术对小鼠一般状态和免疫功能的影响。方法对小鼠进行肝原位瘤切除术,观察手术对小鼠术后不同时间节点自发活动度,淋巴细胞增殖能力,CD4+/CD8+比例等指标的影响。结果与正常小鼠相比,术后第1天小鼠自发活动度减小,差异有统计学意义 ...
赵彤 +8 more
doaj

