Results 31 to 40 of about 764,729 (160)
四川大学学报. 自然科学版, 2010 对段木栽培不同生长期的赤芝水煎液样品,分别进行小鼠负重游泳试验、戊巴比妥钠诱导小鼠睡眠试验、小鼠急性缺血性缺氧试验、对S180荷瘤小鼠瘤重影响试验及对PCI2细胞分化影响试验,并分别测定其多糖和三萜的含量.研究发现,赤芝菌柄期的样品对戊巴比妥钠所致的小鼠睡眠时间有一定的延长作用,对急性脑缺血性耐缺氧的小鼠的喘气时间有显著的增加,并对PC12细胞分化影响最为明显,赤芝子实体期的样品能明显延长小鼠负重游泳时间,抑制S180荷瘤小鼠瘤重.
郑林用 +5 more
doaj
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2014 目的探索最佳的小鼠睾丸支持细胞分离、培养及鉴定方案。研究神经生长因子（nerve growth factor,NGF）对小鼠睾丸支持细胞生理状态的影响。方法通过胶原酶、胰酶等处理分离一周龄小白鼠睾丸支持细胞,通过油红O染色对分离得到的细胞进行鉴定;用加入NGF的培养基和对照培养基分别体外培养小鼠睾丸支持细胞,探索NGF对小鼠睾丸支持细胞生长情况的影响。结果分离得到了较高纯度的小鼠睾丸支持细胞,培养48小时后NGF组的小鼠睾丸支持细胞生长情况明显优于对照组。结论 NGF对小鼠睾丸支持细胞生长有着重要的作用。
付璐璐 +7 more
doaj
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Constructing a porous scaffold with the essential features of natural cancellous bone, including structural architecture and biochemical cues, is one of the pivotal factors for effective bone regeneration. In this study, a biomimetic composite porous Gelatin fibrous scaffold (SrHA/Gelatin) incorporating ultralong strontium‐doped hydroxyapatite
Yin‐Chuan Wang +8 more
wiley +1 more source
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2017 目的分离鉴定多重耐药性铜绿假单胞菌,制备铜绿假单胞菌感染的小鼠烫伤模型。方法常规方法分离纯化铜绿假单胞菌,并经16sRNA序列分析鉴定铜绿假单胞菌;平板稀释法测定分离菌株对18种抗菌药物的耐药性;应用烫伤仪确定小鼠对100℃下不同烫伤面积和烫伤时间的耐受情况,确定最佳烫伤时间和面积建立小鼠烫伤模型;对小鼠烫伤模型皮下感染不同浓度的铜绿假单胞菌,确定72h内全部小鼠死亡的细菌最小致死量,最小致死量感染组小鼠死亡后立即应用平板稀释法检测肝和脾内细菌荷载量。结果分离鉴定得到5株多重耐药性铜绿假单胞菌 ...
郝羽翀 +3 more
doaj
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 4, Page 641-651, December 2025.Key Largo woodrats are a small and endangered island species, whose individuals tend to occur in family groups. Isolation from mainland populations, predation, and habitat fragmentation have caused genetic drift, leading to low overall diversity. Here, we found that a major category 4 hurricane promoted genetic diversity in the Key Largo woodrat ...
Taylor Ackley +5 more
wiley +1 more source
银莲花素A对S180、H22和U14细胞小鼠移植瘤的抑制作用
, 2008 背景与目的:有研究证明,从两头尖中分离得到的三萜皂甙银莲花素A在体外具有较好的抑瘤活性。本研究将观察银莲花素A在体内对小鼠移植瘤的抑制活性。方法:MTT法检测银莲花素A对人鼻咽癌KB细胞和人卵巢癌SKOV3细胞的抑制率。体内实验选取小鼠肉瘤S180细胞、小鼠肝癌H22细胞和小鼠宫颈癌U14细胞,观察银莲花素A注射给药对S180、H22和U14细胞小鼠移植瘤的抑瘤率,以及灌胃给药对小鼠肉瘤S180移植瘤的抑瘤率。测定银莲花素A的急性毒性。结果:银莲花素A在体外对KB细胞和SKOV3细胞的IC50分别为4.
丁立生, 吴凤锷, 王明奎
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