Results 21 to 30 of about 3,087 (179)
A MRI study of white matter changes in mesial temporal lobe epilepsy patients [PDF]
, 2015 目的 运用基于体素的形态学测量（voxel-basedmorphometry,VBM）及基于纤维束骨架的空间统计方法（tract-basedspatialstatistics,TBSS）对内侧颞叶癫痫（mesialtemporallobeepilepsy,MTLE）患者全脑白质体积和白质纤维束弥散张量成像(diffusiontensorimaging,DTI)参数进行分析，并探讨MTLE患者脑白质结构改变与认知水平的关系。 材料和方法 选取24例右利手MTLE患者，其中左侧MTLE12例 ...
席继辉
core
Vulnerability of tropical fish communities across depth in the central Indian Ocean
Conservation Biology, Volume 39, Issue 6, December 2025.Abstract Coral reefs and their fish communities below scuba diving depth (>30 m), in mesophotic coral ecosystems (MCEs) (∼30–150 m), in rariphotic (150–300 m), and in upper bathyal waters (300–500 m) are often underexplored, especially in the Indian Ocean.
Paris V. Stefanoudis +12 more
wiley +1 more source
The neuronal cell cycle regulation mechanism and related animal model in Alzheimer’s disease [PDF]
, 2015 阿尔茨海默病（Alzheimer’sDisease，AD）是一种与年龄相关的神经退行性疾病，它的主要临床表现是记忆和认知功能的逐渐衰退。AD是一种严重影响人类健康的神经退行性疾病，至今仍未找到有效的治疗方法。因此从预防和早期治疗角度考虑，对于AD早期病理变化的研究就十分重要。成熟神经元处于细胞周期静止期，而在AD中，大量神经元的细胞周期被重新激活，但这些神经元不会再分裂而是最终走向了凋亡，这是目前在AD小鼠模型中已知最早的细胞功能紊乱。但对细胞周期重新激活导致神经元凋亡的机制目前还不清楚 ...
李小萍
core
Using online reports of seahorse seizures to track their illegal trade
Conservation Biology, Volume 39, Issue 5, October 2025.Abstract Illegal wildlife trade (IWT) is a persistent and extensive threat to global biodiversity. Hundreds of marine fish species are subject to regulation under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), but it is unclear how much protection species gain from CITES because information on marine fish ...
Sarah J. Foster +3 more
wiley +1 more source
实验性阿尔茨海默模型大鼠海马内病理和PCNAmRNA表达的变化及rLent/NT4-NAP对其的影响
Zhongguo shiyan zhenduanxue, 2011 目的探讨实验性阿尔茨海默病模型大鼠脑内海马光镜下的变化和DNA修复蛋白PCNAmRNA表达的变化,进一步探讨神经保护肽慢病毒rLent/NT4-NAP（NAP）对其具有神经保护作用机制。方法选择无菌级雄性大鼠Wister大鼠40只,随机分为对照组,假手术组,阿尔茨海默（AD）模型大鼠组,rLent/NT4-NAP（NAP）组,每组10只。建立Aβ1-40联合应用转移生长因子β1（TGFβ1）注入实验大鼠左侧海马区制备阿尔茨海默动物模型,通过HE染色观察各组大鼠海马区的形态学改变 ...
白晶, 房绍宽, 张影, 周春奎
doaj
Improvements for better scaling of locally managed marine areas
Conservation Biology, Volume 39, Issue 5, October 2025.Abstract To protect and restore ecosystems at the speed and scale required to meet current environmental challenges, a greater understanding of how conservation initiatives spread from existing to new adopters is required. According to the diffusion of innovation theory, positive adopter‐to‐peer communication is a powerful driver of innovation spread ...
Emily Lewis‐Brown +6 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2007 [目的]通过观察快速衰老小鼠（SAM）在衰老过程中海马中nNOS的分布和表达变化,探讨NO/nNOS在中枢神经系统衰老中的作用。[方法]采用雄性快速衰老亚系8小鼠（SAMP8）及抗快速衰老亚系1小鼠（SAMR1）为研究对象,其中SAMP8为实验组,SAMR1为对照组,每组动物再分为青年组（2月龄）和老年组（10月龄）两组,每个年龄组随机分配6只动物。用免疫组织化学法标记SAM海马中nNOS神经元,观察海马CA1,CA2和CA3区nNOS神经元的形态和分布,并计数nNOS神经元的数量;用RT ...
张立红 +4 more
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The effect of overexpressing SNX8 on the phenotype of Alzheimer’s mice [PDF]
, 2015 阿尔茨海默病（Alzheimerdisease，AD）是最为常见的神经退行性疾病。神经元胞外Aβ（Amyloidβ，Aβ）聚集形成的淀粉样斑是AD的一个重要的病理特征，而Aβ是由淀粉样前体蛋白APP（AmyloidPrecursorProtein，APP）经β-分泌酶（β-secretase）和γ-分泌酶（γ-secretase）依次切割后生成的（即淀粉样蛋白途径），而APP的另一条剪切途径是α-分泌酶（α-secretase）和γ-分泌酶依次对其进行剪切，释放有神经保护作用的sAPPα ...
纪成香
core
Integrative Conservation, Volume 4, Issue 3, Page 430-441, September 2025.Our study identifies southern China, including mountainous regions and islands, as key areas rich in phylogenetic diversity, and phylogenetic endemism of lizards that are currently under‐protected. Current protected areas however do not adequately cover regions that are critical for preserving the evolutionary history of lizards.
Tao Liang (梁涛) +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2011 目的探讨丰富环境干预对短暂性全脑缺血大鼠海马形态学的影响。方法将Wistar大鼠分组建立短暂性全脑缺血模型,进行丰富环境干预,进行大鼠海马形态学分析。结果 HE染色显示,与IS组相比,IE组海马CA1区组织的病理损伤明显减轻。锥体神经元排列较规则,肿胀、固缩及脱失神经元数目较少。Nissl染色显示,IS组海马细胞层数减少,神经元细胞间隙变大,排列稀疏,细胞形态异常,尼氏体大量脱失,染色浅谈且出现较多空白区;IE组海马区仅见少量神经元缺失及胶质增生,但细胞形态基本正常,细胞排列较为整齐,尼氏体较清晰 ...
蔺勇, 郎云峰, 张扬, 程永杰
doaj