Results 21 to 30 of about 4,208 (163)

兴奋毒损伤海马神经细胞机制的研究

open access: yesZhongguo shiyan zhenduanxue, 2003
目的 探讨谷氨酸 (Glutamicacid ,Glu)的神经性兴奋毒损伤作用机制。方法 在体外快速剥离新生大鼠 (0 1天 )双侧海马 ,制成海马神经细胞悬液 ,用Fura 2 /AM负载 ,建立了Fura 2 /AM检测海马神经细胞胞内游离钙离子浓度 ([Ca2 + ]i)的方法 ,并检测Glu兴奋毒对海马神经细胞 [Ca2 + ]i的影响。结果 Fura 2单细胞检测表明 ,静息状态下海马神经细胞 [Ca2 + ]i=2 5 2 .6± 36 .1(nmol/L) ,Glu可使海马神经细胞 ...
咸云淑, 熊文, 程刚
doaj  

The Expression of PolySia/TriSia Associated Proteins and Genes on Developing Brain and the Effect of Dietary Sialic Acid Intervention in Piglets [PDF]

open access: yes, 2015
摘要 研究背景:唾液酸(Sialicacid,Sia)是一类九碳单糖神经氨酸的总称,在细胞表面发挥其多种生物学功能。在体内,Sia通常以游离唾液酸、聚唾液酸(多聚/寡聚)、唾液酸衍生物(糖蛋白,糖脂)这三种形式存在。多聚唾液酸(polySialicacid,ploySia),一种唾液酸残基通过α2-8键连接而成的线性聚合物,广泛分布于在哺乳动物神经系统中,它的主要蛋白载体是神经细胞粘附因子(Neuralcelladhesionmolecule,NCAM)。PolySia-NCAM在细胞迁移、神经突生长 ...
任贺
core  

Improvements for better scaling of locally managed marine areas

open access: yesConservation Biology, Volume 39, Issue 5, October 2025.
Abstract To protect and restore ecosystems at the speed and scale required to meet current environmental challenges, a greater understanding of how conservation initiatives spread from existing to new adopters is required. According to the diffusion of innovation theory, positive adopter‐to‐peer communication is a powerful driver of innovation spread ...
Emily Lewis‐Brown   +6 more
wiley   +1 more source

短暂性全面性遗忘症伴海马损伤的血管危险因素及神经心理因素特征分析 Analysis of Vascular Risk Factors and Neuropsychological Factors in Transient Global Amnesia with Hippocampal Lesions

open access: yesZhongguo cuzhong zazhi
目的 探究短暂性全面性遗忘症(transient global amnesia,TGA)伴海马损伤患者的临床、血管危险因素及神经心理因素特征。 方法 回顾性纳入2015年1月—2024年1月海军军医大学第一附属医院收治的TGA患者,统计TGA伴海马损伤的部位及发病至完成头颅MRI的时间。根据是否伴有海马损伤将TGA患者分为TGA伴海马损伤组和TGA不伴海马损伤组,比较两组患者之间血管危险因素、小血管标志物、大血管狭窄程度、神经心理量表评估结果的差异。 结果 共纳入72例患者,平均年龄(63.7±11.
王为森1,杜冰滢1,李丙翰1,张馨元2,彭雯佳2,毕晓莹1 (WANG Weisen1, DU Bingying1, LI Binghan1, ZHANG Xinyuan2, PENG Wenjia2, BI Xiaoying1 )
doaj   +1 more source

The Role and Mechanism of MicroRNA-219 in Epileptogenesis [PDF]

open access: yes, 2015
目的:通过海人酸、匹罗卡品诱导C57BL/6、ICR小鼠癫痫持续状态发作,制造人类颞叶癫痫动物模型,探讨microRNA-219在癫痫发病中的功能通路及调控网络的动态变化,为癫痫的诊断提供新的依据,为抗痫药物研制提示新的作用靶点。 方法:用成年雄性C57BL/6、ICR小鼠为研究对象,侧脑室注射海人酸(Kainicacid,KA)或腹腔注射匹罗卡品诱发小鼠癫痫发作,建立小鼠癫痫动物模型。24小时后检测小鼠皮质脑电图改变并运用荧光定量PCR方法检测小鼠海马和皮质中microRNA-219表达变化情况 ...
唐荣
core  

Spatial Phylogenetic Analysis of Chinese Lizards: Insights Into Ecological Drivers and Conservation Gaps 中国蜥蜴系统发育的空间分析:生态驱动因素与保护空缺

open access: yesIntegrative Conservation, Volume 4, Issue 3, Page 430-441, September 2025.
Our study identifies southern China, including mountainous regions and islands, as key areas rich in phylogenetic diversity, and phylogenetic endemism of lizards that are currently under‐protected. Current protected areas however do not adequately cover regions that are critical for preserving the evolutionary history of lizards.
Tao Liang (梁涛)   +8 more
wiley   +1 more source

丰富环境干预对短暂性全脑缺血大鼠海马形态学影响

open access: yesZhongguo shiyan zhenduanxue, 2011
目的探讨丰富环境干预对短暂性全脑缺血大鼠海马形态学的影响。方法将Wistar大鼠分组建立短暂性全脑缺血模型,进行丰富环境干预,进行大鼠海马形态学分析。结果 HE染色显示,与IS组相比,IE组海马CA1区组织的病理损伤明显减轻。锥体神经元排列较规则,肿胀、固缩及脱失神经元数目较少。Nissl染色显示,IS组海马细胞层数减少,神经元细胞间隙变大,排列稀疏,细胞形态异常,尼氏体大量脱失,染色浅谈且出现较多空白区;IE组海马区仅见少量神经元缺失及胶质增生,但细胞形态基本正常,细胞排列较为整齐,尼氏体较清晰 ...
蔺勇, 郎云峰, 张扬, 程永杰
doaj  

Study on the nitrogen removal process and influencing factors in the rhizosphere of Sesuvium portulacastrum floating bed [PDF]

open access: yes, 2016
大气是地球氮元素储量最大的氮库,由于氮气的三键结构十分稳定,打开它所需的能量较高,因此在工业革命以前,主要靠闪电固氮和生物固氮将其转化为人和生物可以利用的含氮化合物。然而随着人类社会的不断发展,为了满足人们生产生活的需要,大量氮元素被通过工业的方式固定下来,并随着化肥的滥用积累在环境中,造成氮循环的破坏,并产生水体富营养化现象。富营养化带来的恶果就是水体藻类大量繁殖,溶解氧急剧降低,造成鱼虾等水生生物的死亡等。因此,想要根除富营养化现象就必须将水体过量的氮、磷营养盐从水体脱除 ...
仇元
core  

Contrasting Patterns of Phyllosphere Fungal Diversity Between Angiosperms and Gymnosperms Along a Subalpine‐Elevation Gradient 题目:亚高山海拔梯度上被子植物与裸子植物叶际真菌多样性的相反格局

open access: yesIntegrative Conservation, Volume 4, Issue 3, Page 476-490, September 2025.
The leaf functional traits of angiosperms and gymnosperms in mountain ecosystems significantly influence phyllosphere fungal diversity. These traits are critical for understanding fungal stress resistance and elevational adaptation, which aids in predicting plant responses to climate change.
Xiaocheng Yu   +7 more
wiley   +1 more source

神经元型一氧化氮合酶在快速衰老小鼠海马中的增龄性改变

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2007
[目的]通过观察快速衰老小鼠(SAM)在衰老过程中海马中nNOS的分布和表达变化,探讨NO/nNOS在中枢神经系统衰老中的作用。[方法]采用雄性快速衰老亚系8小鼠(SAMP8)及抗快速衰老亚系1小鼠(SAMR1)为研究对象,其中SAMP8为实验组,SAMR1为对照组,每组动物再分为青年组(2月龄)和老年组(10月龄)两组,每个年龄组随机分配6只动物。用免疫组织化学法标记SAM海马中nNOS神经元,观察海马CA1,CA2和CA3区nNOS神经元的形态和分布,并计数nNOS神经元的数量;用RT ...
张立红   +4 more
doaj  

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