Results 41 to 50 of about 4,482 (163)
The Role of BIN1 in Alzheimer’s Disease [PDF]
, 2015 阿尔茨海默症（Alzheimer’sdisease,AD）是与年龄相关的神经退行性疾病，其主要的病理学特征为由β-淀粉样蛋白(-amyloid,Aβ)聚集产生的老年斑（senileplaues,SP）以及由异常磷酸化的tau蛋白组成的神经纤维缠结（neurofibrillarytangles,NFTs）。Aβ是由淀粉样前体蛋白（-amyloidprecursorprotein,APP）经过β-分泌酶和γ-分泌酶的依次顺序剪切而产生 ...
牛萌萌
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Conservation Biology, Volume 39, Issue 3, June 2025.Abstract Successful long‐term conservation relies on strategic planning for pragmatic actions to mitigate threats. Prioritizing actions and areas to support conservation goals in the most cost‐effective scenario becomes crucial in resource‐limited environments. However, planning and management can be challenging in data‐limited contexts.
Anna Karolina Martins Borges +3 more
wiley +1 more source
High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural medicinal plants [PDF]
, 2016 酶是治疗多种疾病的重要靶标，乙酰胆碱酯酶（AChE）的抑制剂是现阶段治疗阿尔兹海默症（AD）最有效的一类药物。从天然产物中寻找适宜患者长期服用、毒副作用小、作用面广等优点的乙酰胆碱酯酶抑制剂（AChEIs）受到了科研工作者的广泛关注。本论文以AChE作为药物靶标，构建基于高效液相色谱-质谱联用技术（HPLC-MS）的在线生物活性检测方法，发展集分离纯化、结构确证和活性筛选于一体的活性导向天然产物研究方法，用来寻找和发现天然药用植物中潜在的AChEIs候选化合物 ...
刘静兰
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China's Eco‐Civilisation, Climate Leviathan, and Hobbesian Energy Transition
Antipode, Volume 57, Issue 3, Page 830-861, May 2025.Abstract Scholars have hitherto tended to theorise China's ecological civilisation project either as a form of environmental authoritarianism or as a vision of eco‐socialism. This paper contributes to the conversation by conducting a textual analysis of Chinese scholarly discussions on eco‐civilisation.
David Chen
wiley +1 more source
MRI study of the effect of Sialic acid supplementation on piglets working memory [PDF]
, 2015 唾液酸（Sialicacid，Sia）是自然界中一系列酰基化形式神经氨酸衍生物的统称。唾液酸具有多种生物学功能，如：促进细胞的增殖、分化和参与识别；与病原微生物相互作用，参与机体免疫反应；促进神经系统发育，易化记忆形成，提高学习能力；且在大脑发育的关键时期，进行干预可以对大脑造成远期的不可逆的影响。许多动物实验表明唾液酸对大脑发育、学习和记忆能力产生重要影响，仔猪因大脑发育阶段和解剖结构与新生婴儿相似，适合用做研究婴儿脑区变化的动物模型。磁共振成像技术因其对软组织空间分辨率高 ...
吕春龙
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Uncovering Xi Jinping's Policy Agenda: Text As Data Approach
The Developing Economies, Volume 63, Issue 1, Page 9-46, March 2025.How many agendas has Xi Jinping put forth and promoted since taking office in 2012, and what are the types of agendas? How much of political attention has each agenda received, and how has the allocation of attention changed over time? We utilize a dataset of presidential statements, speeches, and reports from 2012 to 2022 and employed automated text ...
Jaehwan Lim, Asei Ito, Hongyong Zhang
wiley +1 more source
Zhongguo youzhi为了揭示雌、雄膨腹海马磷脂组成及其差异，用溶剂萃取法分别提取雌、雄膨腹海马脂质，冷丙酮提取其中的磷脂，进一步采用薄层色谱法和硅胶柱层析分离制备各磷脂组分，利用气相色谱技术分析比较雌、雄膨腹海马磷脂及其各组分的脂肪酸组成。结果表明：雌、雄膨腹海马的磷脂含量丰富，分别占总脂的18.11%和18.72%；膨腹海马磷脂包括磷脂酰乙醇胺、磷脂酰胆碱、溶血磷脂酰胆碱和鞘磷脂，其中磷脂酰胆碱含量最高；膨腹海马磷脂中共鉴定出20种脂肪酸，且不饱和脂肪酸含量高于饱和脂肪酸含量；雌、雄膨腹海马磷脂中海洋特征性n ...
吴娟娟1，田佳宁1，陈奕蒙1，王成成1，王玉明1,2 , 姜晓明1, 薛长湖1, 张恬恬1 WU Juanjuan1, TIAN Jianing1, CHEN Yimeng1, WANG Chengcheng1, WANG Yuming1,2, JIANG Xiaoming1, XUE Changhu1, ZHANG Tiantian1
doaj +1 more source
Mindin is up-regulated during colitis and enhances inflammation by activating the transcription activity of NF-κB protein family [PDF]
, 2015 炎症性肠病（IBD）的发生，被认为是遗传、环境和黏膜免疫三方面因素共同作用的结果,而肠黏膜异常的免疫应答又是发病的关键因素之一。在炎症局部，炎性细胞的招募和激活依赖各种细胞膜受体及整合素与细胞基质（ECM）间的相互作用。细胞外基质蛋白Mindin是Mindin/F-spondin家族成员，在小鼠炎症模型中，有多项研究表明Mindin在免疫应答过程中扮演重要角色，但对于其在炎症中的功能和调控机制研究较少。故本课题拟探索肠炎中Mindin的表达水平及其在炎症中的信号调控机制。 本课题研究中 ...
李萍
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A practical approach to meeting national obligations for sustainable trade under CITES
Conservation Biology, Volume 38, Issue 5, October 2024.Abstract Reconciling conservation goals with sustainable resource use requires adaptive management strategies. The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) regulates global trade for species listed on Appendix II, partly by requiring member countries (parties) to ensure exports do not damage wild ...
Tanvi Vaidyanathan +3 more
wiley +1 more source
实验性阿尔茨海默模型大鼠海马内病理和PCNAmRNA表达的变化及rLent/NT4-NAP对其的影响
Zhongguo shiyan zhenduanxue, 2011 目的探讨实验性阿尔茨海默病模型大鼠脑内海马光镜下的变化和DNA修复蛋白PCNAmRNA表达的变化,进一步探讨神经保护肽慢病毒rLent/NT4-NAP（NAP）对其具有神经保护作用机制。方法选择无菌级雄性大鼠Wister大鼠40只,随机分为对照组,假手术组,阿尔茨海默（AD）模型大鼠组,rLent/NT4-NAP（NAP）组,每组10只。建立Aβ1-40联合应用转移生长因子β1（TGFβ1）注入实验大鼠左侧海马区制备阿尔茨海默动物模型,通过HE染色观察各组大鼠海马区的形态学改变 ...
白晶, 房绍宽, 张影, 周春奎
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