Results 51 to 60 of about 1,280 (139)
Cardiac failure in β-thalassemia: diagnosis, prevention and management
Thalassemia Reports, 2011 Heart failure always represented and still remains the leading cause of mortality in β (β)-thalassemia, despite the therapeutic advances and the considerable amelioration of prognosis accomplished over the last decades.
A. Aessopos, D. Farmakis, V. Berdoukas
doaj +1 more source
Research progress in mitochondrial dynamics-related proteins and ischemic stroke [PDF]
Ischemic stroke is a common acute cerebrovascular disease in clinical practice， which poses a severe threat to human health. In recent years， with deepening understanding of ischemic stroke， significant progress has been made in the diagnosis and ...
Li Tingting, Wang Qinpeng, Liu Xiaoqing, Cai Ke, Wei Yangyang, Liang Cheng
core +1 more source
Research progress in the anti-cancer activity and related mechanisms of arenobufagin [PDF]
Toad venom is an active extract of toad, which is processed by distilling or drying at high temperature the venom secreted from the skin glands and ear-side glands of Toad Chinensis.
BAI Wenhui, SHEN Shukun, WU Yingli
core +1 more source
Research progress on the pathogenesis of acute lung injury in sepsis [PDF]
Sepsis is a systemic inflammatory response syndrome caused by severe infection leading to host dysfunction，often involving multiple organs and causing functional failure.
WANG Qin，YU Xu，LI Qingying，LU Yibin
core +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban铁与高血压的关系近年来已成为心血管领域的重要前沿方向。铁死亡（ferroptosis）作为近年发现的一种铁依赖性细胞死亡形式，已被证实在多数心血管疾病及其相关疾病的发生发展中扮演着十分重要的角色。铁死亡的核心机制涉及铁代谢紊乱、脂质过氧化反应以及抗氧化系统的损伤，这些机制在高血压的病理进程中起着重要作用。铁死亡中铁代谢失衡和脂质过氧化这两者是导致高血压疾病相关血管损伤、血管重构以及高血压靶器官损害的关键因素。本文系统梳理了铁死亡与高血压之间的分子关联及其病理生理机制网络，重点探讨了铁死亡中铁代谢紊乱 ...
刘琪悦, 刘丽军
doaj
β-地中海贫血症患者血清铁调素hepcidin、GDF15表达及与预后的关系
Zhongguo shiyan zhenduanxue, 2022 目的 观察β-地中海贫血症患者血清铁调素hepcidin、生长分化因子15(GDF15)表达水平变化，并分析其与预后的关系。方法 选取汉川市人民医院106例β-地中海贫血症患者（研究组），并选取同期50例体检健康者纳入对照组，检测其血清hepcidin、GDF15水平，随访2年，记录患者生存情况，采用Logistic回归模型分析其预后影响因素。结果 轻型组、重型组与中间型组血清hepcidin水平明显低于对照组（P0.05）;GDF15水平为：重型组>中间型组>轻型组>对照组（P0.05）；死亡组Hb ...
李秀, 谢玉文, 陈会荣
doaj
A preliminary study on the effect mechanism of a rice immune peptide in mice [PDF]
Objective: This study aimed to demonstrate the potential immunomodulatory activity in mice of rice immunopeptide GBP1 （NSVFRALPVDVVANAYR） screened previously.
HUANG Qingming +6 more
core +1 more source
Pulmonary hypertension: an emerging risk in hemoglobin disorders
Thalassemia Reports, 2011 Pulmonary hypertension (PH) is one of the main cardiovascular complications in haemoglobinopathies and is considerably implicated in patients’ morbidity and mortality.
D. Farmakis, A. Aessopos
doaj +1 more source
Zhongguo shiyan zhenduanxue目的 探究C-C趋化因子受体10(C-C chemokine receptor 10,CCR10)在结直肠癌(colorectal cancer, CRC)中对细胞增殖和铁死亡的影响，并探究其影响铁死亡的机制。方法 在GEPIA数据库(Gene Expression Profiling Interactive Analysis)共表达分析CCR10与铁死亡关键基因的相关性。构建慢病毒介导的CCR10过表达(CCR10-OE)、敲除(CCR10-KO)及其阴性对照(NC)稳转HCT116细胞，采用细胞活力(
徐昰栋 +6 more
doaj
Progress on effects of BaP exposure on female reproductive system and pathogenic mechanisms [PDF]
Benzo[a]pyrene (BaP) is the most abundant environmental pollutant among polycyclic aromatic hydrocarbons (PAHs), and is widely distributed in air, water, soil, barbecue, and fried foods. Human beings are inevitably exposed to BaP. Studies have shown that
Qianqian GAO, Xiaoling FENG
core +1 more source