Establishment of a prognostic risk scoring model for patients with pancreatic ductal adenocarcinoma based on cell ferroptosis-related genes and its application value [PDF]
Objective To establish a prognostic risk scoring model for patients with pancreatic ductal adenocarcinoma (PDAC) based on cell ferroptosis-related genes, and to investigate its application value.
QING Gong, JING Xue, JIANG Yueping
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浙江大学学报. 医学版副黏病毒是一类重要的呼吸道病原体，在儿童感染性疾病中具有重要临床意义。其感染过程中可诱导多种形式的程序性细胞死亡（PCD），这些PCD形式在病毒复制、传播及宿主免疫应答中发挥关键作用，显著影响病毒的生命周期及疾病进展。一方面，PCD通过清除被感染细胞有助于限制病毒扩散并激活宿主免疫应答，从而增强抗病毒防御能力；另一方面，过度或异常的细胞死亡可能导致组织损伤和免疫紊乱，为病毒复制提供有利环境，进而加重病情。如细胞凋亡通过外源性与内源性通路参与感染控制，同时亦可能被病毒操控以增强其扩散能力 ...
刘 叶 +3 more
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Role of ferroptosis in acute cadmium-induced liver injury in mice [PDF]
Objective To investigate the role of ferroptosis in acute liver injury induced by cadmium (Cd) exposure in mice. Methods Healthy and clean male ICR mice of 8-10 weeks were randomly divided into control group, and Cd exposure group.
GUO Siyu +6 more
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Biomarkers Screening and Mechanisms Analysis of the Restraint Stress-Induced Myocardial Injury in Hyperlipidemia ApoE-/- Mice [PDF]
Objective To explore the biomarkers and potential mechanisms of chronic restraint stress-induced myocardial injury in hyperlipidemia ApoE-/- mice. Methods The hyperlipidemia combined with the chronic stress model was established by restraining the ApoE-/-
Shang-heng CHEN, Sheng-zhong DONG, Zhi-min WANG, Guang-hui HONG, Xing YE, Zi-jie LIN, Jun-yi LIN, Jie-qing JIANG, Shou-yu WANG, Han-cheng LIN, Yi-wen SHEN
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Diagnosis of iron overload and heart disease by magnetic resonance imaging
Thalassemia Reports, 2011 The use of Magnetic resonance imaging (MRI) to estimate tissue iron was initiated nearly three decades ago but has only become a practical reality in the last ten years.
J.C. Wood, L. Noetzli
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Mechanism by Which Xanthohumol Induces Ferroptosis in SK-N-SH Human Neuroblastoma Cells [PDF]
Objective: To investigate the effect of xanthohumol (XN) on the proliferation inhibition and death mode of SK-N-SH human neuroblastoma cells and to explore the death mechanism of SK-N-SH cells from the perspective of redox homeostasis.
CHU Hongdan, WANG Zhenhua, WANG Fan, LIANG Zheng, HE Hongjun, XU Bo
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Zhongguo shiyan zhenduanxue, 2023 目的 探究表没食子儿茶素没食子酸酯(EGCG)对阿霉素诱导下的心肌细胞铁死亡的影响及其保护机制。方法 体外培养大鼠H9C2心肌细胞，将H9C2心肌细胞分为4组：control组、DOX组、EGCG+DOX组、EGCG+DOX+ML385组进行对应的药物处理。DCFH-DA探针法检测活性氧(ROS);试剂盒检测线粒体膜电位(MMP)、丙二醛(MDA)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)、铁离子(Fe2+);Western blot检测谷胱甘肽过氧化物酶4(GPX4)、核因子E2相关因子2 ...
左振岐, 刘春辉
doaj
Role of Ferroptosis-related Gene GLS2 in Pan-cancer Prognosis and Immunity [PDF]
Objective To assess the role of the ferroptosis-associated gene GLS2 in the prognosis of pan-cancer and immunity using bioinformatics methods. Methods GLS2 expression levels in pan-cancer were profiled using publicly available databases: The Cancer ...
HU Xuexue +4 more
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Transcriptome Analysis of Effect of Cordyceps militaris Aqueous Extract in Human Gastric Cancer Cell BGC-823 on Different RCD Pathways [PDF]
Objective: The main regulated cell death (RCD) signaling pathway of Cordyceps militaris (XG) water extract that affects the growth activity of the human gastric cancer cell line BGC-823 was analyzed and predicted using transcriptome sequencing technology.
Fangxu XU +5 more
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Zhongguo shiyan zhenduanxue, 2019 2012年,Dixon等在探讨Erastin诱导RAS突变的肿瘤细胞发生死亡的作用机制时,发现了一种铁依赖的氧化损伤所引起的新型细胞死亡方式,命名为铁死亡[1],这种细胞死亡方式可能用于治疗肿瘤。野生型(wild-type,wt)p53是一种重要的抑癌基因,可以帮助细胞修复基因缺陷 ...
张佳悦 +5 more
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