Results 191 to 200 of about 20,375 (237)

Synthesis of 1,2,3‐Triazole Analogues of Lincomycin

Helvetica Chimica Acta, 2008
AbstractIn search for new antibiotics we replaced the amide moiety of lincomycin 1 by a 1,2,3‐triazole ring. The 1,2,3‐triazoles 10a–10k were obtained as single regioisomers by ‘click reaction’ of azide 5 with the alkyne 9k, derived from propyl hygric acid, and the alkyl, aryl, or cycloalkyl alkynes ribosomes 9a–9j.
Collin, M P, Hobbie, S N, Böttger, E C, Vasella, A   +3 more
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1,2,3-Triazoles: Gas Phase Properties

The Journal of Organic Chemistry, 2013
1,2,3-Triazoles have come to the forefront as compounds of import in a vast number of applications. The fundamental properties of these species, however, remain largely unknown. Herein, the gas phase properties of 4-phenyl-1,2,3-triazole, benzotriazole, and a series of 1-phenylbenzotriazoles are described.
Kai, Wang, Mu, Chen, Qiaoyi, Wang, Xiaodong, Shi, Jeehiun K, Lee   +4 more
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Synthesis of substituted septanosyl-1,2,3-triazoles

Carbohydrate Research, 2007
A carbohydrate-based oxepine, derived from 2-deoxy-D-arabino-hexopyranose, was used to prepare a family of septanosyl-1,2,3-triazoles in four steps. DMDO mediated epoxidation of the oxepine followed by trapping of the intermediate 1,2-anhydroseptanose by sodium azide gave the beta-substituted glycosyl azide. The septanosyl azide was then reacted with a
Steve, Castro, Emily C, Cherney, Nicole L, Snyder, Mark W, Peczuh   +3 more
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Fluorinated 1,2,3‐Triazoles: Terra Incognita in 1,2,3‐Triazoles Chemistry

ChemistrySelect
Abstract This review is devoted to the synthesis and application of fluoro‐substituted 1,2,3‐triazoles. The analysis of the available studies of fluorinated triazoles indicates exceptional value properties especially for biomedical research, despite the significant limitations of synthetic methods of their preparation.
Nazariy Pokhodylo, Kostiantyn Levchenko, Mykola Obushak   +2 more
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1,2,3-Triazoles. Part II. 4-Amino-5-aminomethyl-1,2,3-triazoles

Journal of the Chemical Society, Perkin Transactions 1, 1973
4-Amino-1-(and 2-)methyl-1,2,3-triazole-5-carbonitrile were made by acidic hydrolysis of 4-dimethylaminomethyleneamino-1-(and 2-)methyl-1,2,3-triazole-5-carbonitrile. These amino-nitriles, and also their known 3-methyl- and 3-benzyl-analogues, were hydrogenated to 4-amino-5-aminomethyl-1-methyl-1,2,3-triazole (1a) and its 2- and 3-methyl- and 3-benzyl ...
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Synthesis of glucosylated 1,2,3-triazole derivatives

Carbohydrate Research, 1999
A series of potential bioactive compounds, 1-glucosyl-4-heterocyclyl-5-(p-substituted-phenyl)-1,2,3-triazoles , were synthesized. Highly stereoselective products were obtained in good yield. Primary activity screening showed that this type of N-glucosylic compound possessed antitumour and antiviral activities.
X M, Chen, Z J, Li, Z X, Ren, Z T, Huang
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Method for Assigning Structure of 1,2,3-Triazoles

The Journal of Organic Chemistry, 2012
1,4-Disubstituted-1H-1,2,3-triazoles 1 can easily be distinguished from the isomeric 1,5-disubstituted-1H-1,2,3-triazoles 2 by simple one-dimensional (13)C NMR spectroscopy using gated decoupling. The C(5) signal of 1 appears at δ ∼120 ppm, while the C(4) signal of 2 appears at δ ∼133 ppm. Computational studies also predict the upfield shift of C(5) of
Xavier, Creary, Andrew, Anderson, Carl, Brophy, Frances, Crowell, Zachary, Funk   +4 more
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Structural basis of the impact sensitivities of 1-picryl-1,2,3-triazole, 2-picryl-1,2,3-triazole, 4-nitro-1-picryl-1,2,3-triazole, and 4-nitro-2-picryl-1,2,3-triazole

The Journal of Physical Chemistry, 1989
The isomeric pairs 1-picryl-1,2,3-triazole, 2-picryl-1,2,3-triazole and 4-nitro-1-picryl-1,2,3-triazole, 4-nitro-1-picryl-1,2,3-triazole differ dramatically in their impact sensitivity. Since these pairs of compounds have identical oxygen balance this strongly suggests that there is a difference in the decomposition mechanism.
C. B. Storm, R. R. Ryan, J. P. Ritchie, J. H. Hall, S. M. Bachrach   +4 more
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Mass spectra of 1,2,3-triazoles

Journal of the Chemical Society, Perkin Transactions 1, 1979
The mass spectra of substituted 1,2,3-triazoles [RTR′, (1)](R′= H, CO2X, COR″, pyrazolyl, or isoxazolyl) are discussed. For a wide variety of structural types, P+ is always strong and [P+ 1]+ is often of significant intensity. Subsequent breakdown patterns are strongly dependent on the substituents R and R′.
Sidney I. Miller, Ruey-Rong Lii, Yoshinari Tanaka   +2 more
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A vibrational assignment for 1,2,3-triazole

Journal of the Chemical Society B: Physical Organic, 1969
I.r. spectra of 1,2,3-triazole in the vapour and liquid states and in solution are reported and discussed. From these, and by comparison with the spectra of other simple five-membered heterocycles, vibrational assignments are proposed. The i.r. spectra is satisfactorily interpreted in terms of an asymmetric structure.
E. Borello, A. Zecchina, E. Guglielminotti   +2 more
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