Results 81 to 90 of about 4,400 (190)

Triazoles as promising small molecules anticancer agents [PDF]

Records of Pharmaceutical & Biomedical Sciences
The 1,2,3-triazole scaffold has emerged as a pivotal heterocyclic motif in medicinal chemistry due to its unique physicochemical properties, synthetic accessibility, and broad spectrum of biological activities. These five-membered nitrogen-rich rings are
Mennatallah Shaheen, Khaled Darwish, Safaa Kishk, Magda Elsayed, Ismail Salama   +4 more
doaj   +1 more source

Exploring the Anticancer Activity of Ruthenium(II)–Arene and Copper(I) Complexes Bearing N‐Heterocyclic Carbene Ligands Containing Azido, Pyridinium, and Ethisterone‐Derived Triazole Groups

European Journal of Inorganic Chemistry, Volume 29, Issue 24, 21 August 2026.
A versatile library of backbone‐functionalized N‐heterocyclic carbene (NHC) ligands was developed and efficiently converted into Cu(I) and Ru(II) NHC complexes, demonstrating that ligand functionalization strongly modulates anticancer activity, with Cu(I)–NHC species showing potent and selective antiproliferative effects against ovarian and breast ...
Alessia Schiavo, Chiara Tupini, Nicola Demitri, Ilaria Lampronti, Thomas Scattolin   +4 more
wiley   +1 more source

Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry

Beilstein Journal of Organic Chemistry, 2015
The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles.
Zhan-Jiang Zheng, Ding Wang, Zheng Xu, Li-Wen Xu   +3 more
doaj   +1 more source

Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas 1,2,3-triazolic heterocycles: history, preparations, applications and pharmacological activities

Química Nova, 2006
The 1,2,3-triazole, known since the end of 19th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds.
Júlio O. F. Melo, Claudio Luis Donnici, Rodinei Augusti, Vitor F. Ferreira, Maria Cecília B. V. de Souza, Maria Lourdes G. Ferreira, Anna C. Cunha   +6 more
doaj   +1 more source

The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel, Thomas R. Talbot IV, Matthias Zeller, Davin G. Piercey   +3 more
wiley   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Azide–alkyne cycloaddition (click) reaction in biomass-derived solvent CyreneTM under one-pot conditions

Beilstein Journal of Organic Chemistry
It was demonstrated that CyreneTM, as a biomass-originated polar aprotic solvent, could be utilized as an alternative reaction medium for one-pot copper(I)-catalyzed azide–alkyne cycloaddition (click or CuAAC) reactions, for the synthesis of various 1,2 ...
Zoltán Medgyesi, László T. Mika
doaj   +1 more source

A Regioselective Approach to Accessing Trisubstituted Pyrrolo[2,3-d][1,2,3]triazoles via an Orthogonal Protection Strategy

Molecules
The first access to N-2, N-4-disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported herein. The series was generated using an orthogonal protecting group strategy from N-1, N-4-disubtituted pyrrolo[2,3-d][1,2,3]triazoles. N-Arylation by Ullman–Goldberg
Kévin Brugemann, Simon Garnier, Johnny Vercouillie, Sylvain Routier, Frédéric Buron   +4 more
doaj   +1 more source

Combined XRD-paramagnetic 13C NMR spectroscopy of 1,2,3-triazoles for revealing copper traces in a Huisgen click-chemistry cycloaddition. A model case

Heterocyclic Communications, 2019
Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) click chemistry robustness has been demonstrated over recent years to produce 1,2,3-triazoles with excellent yields at mild conditions with simple purification methods.
Canseco-González Daniel, O José Luis Rodríguez de la, Herbert-Pucheta José Enrique   +2 more
doaj   +1 more source

A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações

Química Nova, 2011
The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily ...
Luiza Baptista de Oliveira Freitas, Fernando Armini Ruela, Guilherme Rocha Pereira, Rosemeire Brondi Alves, Rossimiriam Pereira de Freitas, Leandro José dos Santos   +5 more
doaj   +1 more source