Results 71 to 80 of about 43,142 (242)

1,2,3-Triazole N(2)-chelated C–S coupling: Access to ortho methylthiolated 1,2,3-triazoles

, 2019
CuF2-mediated selective C-S coupling of 1,4-disubstituted 1,2,3-triazole halides using the widely available DMSO as the methylthiolation reagent were achieved through the chelation of N(2) atom in triazole ring. The ortho- C-halogen bond in N(1) aryl was
Yubo Jiang (4426555), Yaowen Liu (4426561), Jiazhuang Wang (5851049), Huiling Cheng (2898452), Shengtao Yu (4400917), Fang Luo (277928)   +5 more
core   +1 more source

1,2,3-Triazole-Based Hybrids as EGFR Inhibitors: An overview [PDF]

Records of Pharmaceutical & Biomedical Sciences
Cancer continues to be a leading cause of mortality worldwide, presenting a major global public health concern. Despite advances in treatment, the discovery and development of effective anticancer drugs remain significant challenges for medicinal ...
Asmaa Yassen, Nareman A. Nawareg, Ebtehal M. Husseiny, Magda A. A. El-Sayed, Hosam Elshihawy   +4 more
doaj   +1 more source

Regioselective synthesis, characterization and antimicrobial evaluation of amide-ether linked 1,4-disubstituted 1,2,3-triazoles [PDF]

Journal of the Serbian Chemical Society, 2017
Regioselective synthesis of some amide–ether-linked 1,4-disubstituted 1,2,3-triazoles was realized via the copper(I)-catalyzed click reaction of 1-(prop-2-ynyloxy)naphthalene, 2-(prop-2-ynyloxy)naphthalene and 1,4-bis-(prop-2-ynyloxy)benzene with 2-azido-
Kaushik Chander Prakash, Kumar Krishan, Kumar Devinder, Mor Satbir, Kumar Ashwani, Kumar Jindal Deepak   +5 more
doaj   +1 more source

p-Toluenesulfonic acid-promoted autocatalytic hydrolyzation of 1-tosyl-1,2,3-triazoles

, 2018
The first example of autocatalytic hydrolyzation of 4-aryl-1-tosyl-1,2,3-triazoles induced by p-toluenesulfonic acid was reported, providing an effective and metal-free synthetic approach to deliver a broad range of new 4-aryl-2H-1,2,3-triazoles in good ...
Dongdong Zhang (644246), Min Shi (141075), Renjie Fang (5048321), Hao Wei (1649206), Qingyang Du (1361358), Zhuoya Dong (5048324), Haohao Dong (587684), Feijun Wang (2181208)   +7 more
core   +1 more source

Ligand Control of Copper-Mediated Cycloadditions of Acetylene to Azides: Chemo- and Regio-Selective Formation of Deutero- and Iodo-Substituted 1,2,3-Triazoles

, 2023
The participation of σ-monocopper and σ-bis-copper acetylide in mechanistic pathways for copper-catalyzed cycloaddition (CuAAC) reactions of acetylene with azides was probed by analysis of deuterium distributions in the 1,2,3-triazole product formed by ...
Shanguang Qiu (17707543), Yunlong Wei (4600126), Yanmei Zhao (388081), Luyong Wu (17707546), Dongying Li (3777847)   +4 more
core   +1 more source

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

Bulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah, Amirreza Mottafegh, Su‐Hyun Yoo, Jongwoon Kim, Minseon Byeon, Juhwan Noh, Yea‐Lee Lee, Jin Suk Myung, Gwang‐Noh Ahn   +8 more
wiley   +1 more source

Synthesis of a Novel Series of Cu(I) Complexes Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Homogeneous and Carbon-Supported Catalysts for the Synthesis of 1- and 2-Substituted-1,2,3-triazoles

Nanomaterials, 2021
The N-alkylation of 1,3,5-triaza-7-phosphaadamantane (PTA) with ortho-, meta- and para-substituted nitrobenzyl bromide under mild conditions afforded three hydrophilic PTA ammonium salts, which were used to obtain a new set of seven water-soluble copper ...
Ivy L. Librando, Abdallah G. Mahmoud, Sónia A. C. Carabineiro, M. Fátima C. Guedes da Silva, Carlos F. G. C. Geraldes, Armando J. L. Pombeiro   +5 more
doaj   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Novel allyl-hydrazones including 2,4-dinitrophenyl and 1,2,3-triazole moieties as optical sensor for ammonia and chromium ions in water

BMC Chemistry, 2022
It is critical to take safety action if carcinogenic heavy metals and ammonia can be detected quickly, cheaply, and selectively in an environmental sample. As a result, compound 4a [4-(1-(2-(2,4-Dinitrophenyl)hydrazineylidene)-3-(naphthalen-2-yl)allyl)-5-
Hanan A. Mohamed, Bakr F. Abdel-Wahab, Mahmoud N. M. Yousif, Reda M. Abdelhameed   +3 more
doaj   +1 more source

Electrospun Porous Materials for the Next‐Generation Proton Exchange Membrane Fuel Cells: Progress, Challenges, and AI‐Optimized Perspectives

Carbon Energy, EarlyView.
Incorporating AI to optimize solution, process, and environment enables efficient prediction of structural properties and performance, allowing tailoring of GDL, CL, and PEM fabrication to guide PEMFC toward 9.0 kW L‒1 by 2040. ABSTRACT The performance and commercial viability of proton exchange membrane fuel cells (PEMFCs) are constrained by key ...
Shangfeng Jiang, Panfeng Wang, You Gong, Zeyu Sun, Huatan Chen, Geng Wang, Ting Tao, Chuang Zhai, Xi Wang, Ruixin Chen, Jiaxin Jiang, Bingrong Zhang   +11 more
wiley   +1 more source