Results 71 to 80 of about 4,400 (190)

Chemoselective Aldehyde and Imine Reduction by a Macrocyclic Triazole–Borane Complex Triggered by a Non‐innocent Proton–Hydride Interaction

European Journal of Organic Chemistry, EarlyView.
This work describes the study on a new recyclable reagent, based on a macrocyclic triazole–borane complex. It showed high chemoselectivity for aldehyde reduction and reductive amination over ketones. This selectivity is driven by a noncovalent hydride–proton interaction that stabilizes the transition state for aldehydes but is sterically inhibited in ...
Luca Di Marino, Artur Brotons Rufes, Rosaria Schettini, Giorgio Della Sala, Francesco De Riccardis, Chiara Costabile, Irene Izzo   +6 more
wiley   +1 more source

Reaction of 4-acetyl-1,2,3-triazol-5-olate with hydrazine derivatives

Chimica Techno Acta, 2015
1,2,3-triazole attracts attention because of the ability opening ring to form α-diazoimin and intramolecular rearrangements with the formation of various heterocyclic systems.
I. S. Khazhieva, T. V. Glukhareva, Yu. Yu. Morzherin   +2 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

“Click” Synthesis of Nonsymmetrical Bis(1,2,3-triazoles)

Organic Letters, 2010
Unsymmetrically 1,1'-disubstituted 4,4'-bis-1H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a "double-click" strategy, two complementary approaches were implemented for the preparation of the key 4-ethynyltriazole intermediates 5: (a) the stepwise Swern oxidation/Ohira-Bestman alkynylation of readily ...
Aizpurua, Jesús M., Azcune, Itxaso, Fratila, Raluca M., Balentová, Eva, Sagartzazu-Aizpurua, Maialen, Miranda, José Ignacio   +5 more
openaire   +3 more sources

Electrochemical investigation of radical‐radical recognition in viologen‐based ditopic structures

Responsive Materials, EarlyView.
The so‐called “blue box” is one of the most studied macrocycles. Yet, functionalized macrocycles of this type are rarely investigated. This work describes the radical‐radical recognition properties of ditopic structures, including functionalized blue‐box macrocycles.
Ahmad Bachir, Fabiana Ciocchetti, Caterina Baccini, Sayed Suliman Shah, Andrea Secchi, Cristian Pezzato, Giulio Ragazzon   +6 more
wiley   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Copper on Calcium Carbonate and Marble Waste as Recyclable Catalysts for Ultrasound‐Assisted One‐Pot Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
A sustainable CaCO3‐supported copper catalyst, prepared by simple adsorption of Cu(II) onto natural and marble waste‐derived carbonate materials, promotes ultrasound‐assisted CuAAC reaction in water. The work provides straightforward access to 1,4‐disubstituted 1,2,3‐triazoles under mild conditions while combining catalyst recyclability with the ...
Riccardo Serra, Dipak J. Fartade, Pietro Caboni, Cristina Carucci, Andrea Salis, Enrica Tuveri, Antonella Rossi, Andrea Citarella, Andrea Porcheddu   +8 more
wiley   +1 more source

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes

Beilstein Journal of Organic Chemistry, 2018
A copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported.
Muhammad Israr, Changqing Ye, Munira Taj Muhammad, Yajun Li, Hongli Bao   +4 more
doaj   +1 more source