Results 141 to 150 of about 4,245 (200)

New 1,2,4-oxadiazole derivatives as potential multifunctional agents for the treatment of Alzheimer's disease: design, synthesis, and biological evaluation. [PDF]

BMC Chem
Ayoup MS, Ghanem M, Abdel-Hamid H, Abu-Serie MM, Masoud A, Ghareeb DA, Hawsawi MB, Sonousi A, Kassab AE.   +8 more
europepmc   +1 more source

1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry. [PDF]

ACS Med Chem Lett, 2021
Aprile S, Riva B, Bhela IP, Cordero-Sanchez C, Avino G, Genazzani AA, Serafini M, Pirali T.   +7 more
europepmc   +1 more source

Design and synthesis of new 1,2,4-oxadiazole/quinazoline-4-one hybrids with antiproliferative activity as multitargeted inhibitors. [PDF]

Front Chem
Mohamed AM, Abou-Ghadir OMF, Mostafa YA, Dahlous KA, Bräse S, Youssif BGM.   +5 more
europepmc   +1 more source

Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. [PDF]

ACS Med Chem Lett, 2021
Stott AJ, Maillard MC, Beaumont V, Allcock D, Aziz O, Borchers AH, Blackaby W, Breccia P, Creighton-Gutteridge G, Haughan AF, Jarvis RE, Luckhurst CA, Matthews KL, McAllister G, Pollack S, Saville-Stones E, Van de Poël AJ, Vater HD, Vann J, Williams R, Yates D, Muñoz-Sanjuán I, Dominguez C.   +22 more
europepmc   +1 more source

1,2,4-Oxadiazole Derivatives: Physicochemical Properties, Antileishmanial Potential, Docking and Molecular Dynamic Simulations of Leishmania infantum Target Proteins. [PDF]

Molecules
Barbosa DCS, Holanda VN, Lima EMA, Cavalcante MKA, Brelaz-de-Castro MCA, Chaves EJF, Rocha GB, Silva CJO, Oliveira RN, Figueiredo RCBQ.   +9 more
europepmc   +1 more source

Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway. [PDF]

Acta Pharmacol Sin
Luo ZH, Guo JS, Pang S, Dong W, Ma JX, Zhang L, Qi XL, Guan FF, Gao S, Gao X, Liu N, Pan S, Chen W, Zhang X, Zhang LF, Yang YJ.   +15 more
europepmc   +1 more source

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents. [PDF]

RSC Med Chem
Ayoup MS, Barakat MR, Abdel-Hamid H, Emam E, Al-Faiyz YS, Masoud AA, Ghareeb DA, Sonousi A, Kassab AE.   +8 more
europepmc   +1 more source

1,2,4-Oxadiazole-Based Bio-Isosteres of Benzamides: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo. [PDF]

Int J Mol Sci, 2021
Yang S, Ren CL, Ma TY, Zou WQ, Dai L, Tian XY, Liu XH, Tan CX.   +7 more
europepmc   +1 more source

New Alpha9 nAChR Ligands Based on a 5-(Quinuclidin-3-ylmethyl)-1,2,4-oxadiazole Scaffold. [PDF]

ACS Chem Neurosci
Dallanoce C, Richter K, Stokes C, Papotto C, Andleeb H, Thakur GA, Kerr A, Grau V, Papke RL.   +8 more
europepmc   +1 more source

Novel late-stage radiosynthesis of 5-[18F]-trifluoromethyl-1,2,4-oxadiazole (TFMO) containing molecules for PET imaging. [PDF]

Sci Rep, 2021
Turkman N, Liu D, Pirola I.
europepmc   +1 more source