Results 121 to 130 of about 101,287 (245)

Simple and Efficient Synthesis of Diamino Derivatives of bis-1,2,4-oxadiazole via Tandem Staudinger/aza-Wittig Reaction. [PDF]

Curr Org Synth, 2023
Xie H, Hu QQ, Zhang YL, Qin XT, Li L.
europepmc   +1 more source

Focused microwave irradiation-assisted synthesis of N-cyclohexyl-1,2,4-oxadiazole derivatives with antitumor activity

, 2019
A facile synthesis of 3,5-disubstituted 1,2,4-oxadiazole derivatives under focused microwave irradiation (FMWI) is reported. Arylamidoximes 1a–i and dicyclohexylcarbodiimide (DCC) were carried out in DMF under FMWI to obtain 1,2,4-oxadiazoles 2a–i in 61 ...
Roberto Nicolete (90567), Vanessa Pinheiro Gonçalves Ferreira (5829473), Ronaldo Nascimento de Oliveira (5829482), Cláudia do Ó Pessoa (5829479), Héverton Mendes Araújo (5829476), Franciane Gonçalves dos Santos (5829470), Valentina Nascimento Melo de Oliveira (5829467)   +6 more
core   +1 more source

3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM

Pharmaceuticals
Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Tatiana V. Zinevich, Ivan O. Maslov, Olga G. Kirichenko, Sergey V. Shorshnev, Maxim A. Gureev, Fedor M. Dolgushin, Yuri B. Porozov, Vladimir M. Trukhan   +7 more
doaj   +1 more source

New 1,2,4-oxadiazole derivatives with positive mGlu₄ receptor modulation activity and antipsychotic-like properties. [PDF]

J Enzyme Inhib Med Chem, 2022
Stankiewicz A, Kaczorowska K, Bugno R, Kozioł A, Paluchowska MH, Burnat G, Chruścicka B, Chorobik P, Brański P, Wierońska JM, Duszyńska B, Pilc A, Bojarski AJ.   +12 more
europepmc   +1 more source

The preparation and rearrangement of 3- pyridyl-4-alkyl (or aryl)-1,2,4- oxadiazole-5 (4h)-thiones

, 1991
3-Pyridyl-4-alkyl (or aryl)-1,2,4-oxadiazole-5(4H)-thiones are prepared by the reaction of N-alkyl (or aryl) pyridine carboxamide oximes with thiophosgene.
Ağırbaş, Hikmet, Dürüst, Yaşar
core   +1 more source

Boosting the Energetic Performance of Trinitromethyl-1,2,4-oxadiazole Moiety by Increasing Nitrogen-Oxygen in the Bridge. [PDF]

Int J Mol Sci, 2022
Chen P, Dou H, He C, Pang S.
europepmc   +1 more source

Rearrangements of 1,2,4-Oxadiazole: "One Ring to Rule Them All"

, 2017
[Figure not available: see fulltext.] 1,2,4-Oxadiazoles are heterocycles characterized by low aromaticity and the presence of a weak OâN bond and are widely studied due to their tendency to rearrange into more stable heterocyclic compounds.
Antonio Palumbo Piccionello, Buscemi, Silvestre, Silvestre Buscemi, Andrea Pace, Piccionello, Antonio Palumbo, Pace, Andrea   +5 more
core   +1 more source

New Marine-Inspired Oxadiazole Derivatives for Use Against Pancreatic Ductal Adenocarcinoma

Marine Drugs
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with limited effective therapeutic options due to late diagnosis, aggressive progression, and rapid development of drug resistance.
Camilla Pecoraro, Daniela Carbone, Fares Hezam Mohammed Al Ostoot, Mahrou Vahabi, Giulia Lencioni, Patrizia Diana, Elisa Giovannetti, Barbara Parrino   +7 more
doaj   +1 more source

Discovery of 3-phenyl-1,2,4-oxadiazole derivatives as a new class of SARS-CoV-2 main protease inhibitors. [PDF]

Bioorg Med Chem Lett, 2023
Guo N, Huang C, Qiao J, Li Y, Wang Y, Xia A, Zhang G, Fang Z, You J, Li L.   +9 more
europepmc   +1 more source

Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: The special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole

, 2013
The combination of experimental (inhibition of colchicine binding) and computational (COMPARE, docking studies) data unequivocally identified diaryl 5-amino-1,2,4-oxadiazoles as potent tubulin inhibitors.
Hamel, Ernest, Nguyen, Tam Luong, A. Gakh, Andrei, V. Sosnov, Andrey, Krasavin, Mikhail   +4 more
core   +1 more source