Results 111 to 120 of about 101,287 (245)

5-(1H-1,2,3-Benzotriazol-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

, 2008
In the title molecule, C15H11N5O, the 1,2,3-benzotriazole and 3-phenyl-1,2,4-oxadiazole units are individually essentially planar and the dihedral angle between them is 80.2 (2)°.
Shu-Qing Xu, Jia-Ming Li
core   +1 more source

A Critical Examination of Synthetic Approaches and Pharmacological Profiles of 1,2,4-Oxadiazole Derivatives

<p><strong><span>Background:</span></strong><span> </span></p> <p><span>The previous study about the 1,2,4-oxadiazole heterocyclic ring for its distinctive bio-isosteric characteristics and ...
Priyanka B. Khedekar*, Shweta V. Rane, Namrata D. Dhote, Dhanshree Bawane , Aniket Murkute , Alpana j. Asnani , Datta Avhad
core   +1 more source

Design, synthesis, and biological evaluation of a novel series of 1,2,4-oxadiazole inhibitors of SLACK potassium channels: Identification of in vitro tool VU0935685. [PDF]

Bioorg Med Chem, 2023
Qunies AM, Spitznagel BD, Du Y, David Weaver C, Emmitte KA.   +4 more
europepmc   +1 more source

Modes of Action of a Novel c-MYC Inhibiting 1,2,4-Oxadiazole Derivative in Leukemia and Breast Cancer Cells. [PDF]

Molecules, 2023
Zhou M, Boulos JC, Omer EA, Klauck SM, Efferth T.   +4 more
europepmc   +1 more source

Total Synthesis of Anhydrolycorinone Utilizing Sequential Intramolecular Diels−Alder Reactions of a 1,3,4-Oxadiazole

, 2016
A convergent total synthesis of anhydrolycorinone is detailed, enlisting sequential intramolecular Diels−Alder reactions of a suitably substituted 2-amino-1,3,4-oxadiazole defining a novel oxadiazole → furan → benzene Diels−Alder ...
Dale L. Boger (1306542), Scott E. Wolkenberg (1639027)   +1 more
core   +1 more source

Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat. [PDF]

J Med Chem, 2023
Barbachyn MR.
europepmc   +1 more source

C-13 NMR study of substituent effects in 1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives

, 2004
C-13 chemical shifts of C=N, C=O and C=S carbons of 3,4-distibstituted-1,2,4-oxadiazole-5-ones(thiones) and 3,4-disubstituted-1,2,4-thiadiazole-5-ones have been determined ill CDCl3 solution.
Kara, YEŞİM SANİYE, Agirbas, H
core   +1 more source

Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity

Molecules
A series of 13 new 3-substituted 5-(5-nitro-2-furyl)-1,2,4-oxadiazoles was synthesized from different aminonitriles. All compounds were screened in the disc diffusion test at a 100 μg/mL concentration to determine the bacterial growth inhibition zone ...
Lyubov Vinogradova, Alexey Lukin, Kristina Komarova, Maxim Zhuravlev, Artem Fadeev, Mikhail Chudinov, Elizaveta Rogacheva, Lyudmila Kraeva, Maxim Gureev, Yuri Porozov, Marine Dogonadze, Tatiana Vinogradova   +11 more
doaj   +1 more source

Synthesis and chemical characterization of CuII, NiII and ZnII complexes of 3,5-bis(20-pyridyl)-1,2,4-oxadiazole and 3-(20-pyridyl)5-(phenyl)-1,2,4-oxadiazole ligands

, 2011
The synthesis and structural characterization of NiII, CuII and ZnII complexes of two chelating 1,2, 4-oxadiazole ligands, namely 3,5-bis(20-pyridyl)-1,2,4-oxadiazole (bipyOXA) and 3-(20-pyridyl)5- (phenyl)-1,2,4-oxadiazole (pyOXA), is here reported ...
Giorgi, G, Giorgi, Gianluca, Antonio Palumbo Piccionello, Piccionello, Antonio Palumbo, BARONE, Giampaolo, Annalisa Guarcello, TERENZI, Alessio, PALUMBO PICCIONELLO, Antonio, Giampaolo Barone, GUARCELLO, Annalisa, Alessio Terenzi, Andrea Pace, PACE, Andrea, Gianluca Giorgi   +13 more
core   +1 more source

A Novel 3-meta-Pyridine-1,2,4-oxadiazole Derivative of Glycyrrhetinic Acid as a Safe and Promising Candidate for Overcoming P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells. [PDF]

ACS Omega, 2023
Moralev AD, Salomatina OV, Chernikov IV, Salakhutdinov NF, Zenkova MA, Markov AV.   +5 more
europepmc   +1 more source