, 2013 The combination of experimental (inhibition of colchicine binding) and computational (COMPARE, docking studies) data unequivocally identified diaryl 5-amino-1,2,4-oxadiazoles as potent tubulin inhibitors.
Hamel, Ernest +4 more
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Investigation of 3,5-diamino-1,2,4-oxadiazole as a precursor for energetic salts
1,2,4-Oxadiazole is an attractive backbone for energetic materials as it shows a positive impact on the oxygen balance compared to other heterocycles like imidazole or triazole. The suitability of 1,2,4-oxadiazole as a cation in energetic salts should be
Lieber, Patrick +2 more
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Modes of Action of a Novel c-MYC Inhibiting 1,2,4-Oxadiazole Derivative in Leukemia and Breast Cancer Cells. [PDF]
Molecules, 2023 Zhou M +4 more
europepmc +1 more source
5-(1H-1,2,3-Benzotriazol-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole
, 2008 In the title molecule, C15H11N5O, the 1,2,3-benzotriazole and 3-phenyl-1,2,4-oxadiazole units are individually essentially planar and the dihedral angle between them is 80.2 (2)°.
Shu-Qing Xu, Jia-Ming Li
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A new series of thioethers containing a 1,2,4-oxadiazole ring were synthesized by the modified Riemschneider reaction. The corresponding thiocyanate derivatives of 1,2,4-oxadiazoles were obtained in good yields by the reaction of 3-aryl-5-chloromethyl-1 ...
Noma, Samir Abbas Ali +4 more
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An ANRORC approach to the synthesis of perfluoroalkylated 1,2,4-triazole-carboxamides
, 2009 A series of perfluoroalkyl-1,2,4-triazole-carboxamides has been obtained through an ANRORClike rearrangement (Addition of Nucleophile, Ring-Opening and Ring-Closure) of 5- perfluoroalkyl-1,2,4-oxadiazole-3-carboxamides with methylhydrazine or hydrazine.
PALUMBO PICCIONELLO, Antonio +7 more
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S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors. [PDF]
Molecules, 2023 Mauchauffée E +10 more
europepmc +1 more source
<p><strong><span>Background:</span></strong><span> </span></p> <p><span>The previous study about the 1,2,4-oxadiazole heterocyclic ring for its distinctive bio-isosteric characteristics and ...
Priyanka B. Khedekar*, Shweta V. Rane, Namrata D. Dhote, Dhanshree Bawane , Aniket Murkute , Alpana j. Asnani , Datta Avhad
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Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat. [PDF]
J Med Chem, 2023 Barbachyn MR.
europepmc +1 more source
A Novel 3-meta-Pyridine-1,2,4-oxadiazole Derivative of Glycyrrhetinic Acid as a Safe and Promising Candidate for Overcoming P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells. [PDF]
ACS Omega, 2023 Moralev AD +5 more
europepmc +1 more source