Results 131 to 140 of about 101,287 (245)

Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice. [PDF]

Drug Des Devel Ther, 2022
Luo Z, Wang Y, Pang S, Gao S, Liu N, Gao X, Zhang L, Qi X, Yang Y, Zhang L.   +9 more
europepmc   +1 more source

Design and Synthesis of 1,2,4-Oxadiazole Derivatives as Non-Steroidal 5 Alpha-Reductase Inhibitors

, 2009
The purpose of this study was to synthesize compounds in which the 1,2,4- oxadiazole moiety replaced the amide bond of ONO3805 and to evaluate its 5 alpha-reductase inhibitory activity as a potential benign prostatic hyperplasia therapeutic target.
CHERN, JI-WANG, 陳基旺
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Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists. [PDF]

Molecules, 2023
Finamore C, Festa C, Fiorillo B, Leva FSD, Roselli R, Marchianò S, Biagioli M, Spinelli L, Fiorucci S, Limongelli V, Zampella A, De Marino S.   +11 more
europepmc   +1 more source

Benzamides Substituted with Quinoline-Linked 1,2,4-Oxadiazole: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo. [PDF]

Molecules, 2022
Sun BL, Wang YY, Yang S, Tu MT, Shao YY, Hua Y, Zhou Y, Tan CX.   +7 more
europepmc   +1 more source

Synthesis of Some 3-Aryl-1,2,4-oxadiazoles Carrying a Protected L-Alanine Side Chain

Journal of the Brazilian Chemical Society, 1998
The synthesis of some 1,2,4-oxadiazole derivatives (4a-d) starting from arylamidoximes 1a-d and N-t-butoxycarbonyl-O-benzyl-L-aspartic acid is described. The structures of these new products have been determined by spectroscopic methods.
Melo Sebastião J. de, Sobral Antônio D., Lopes Heron de Lima, Srivastava R.M.   +3 more
doaj  

Synthesis, biological activity and toxicity to zebrafish of benzamides substituted with pyrazole-linked 1,2,4-oxadiazole. [PDF]

RSC Adv, 2022
Shao Y, Tu M, Yang S, Wang Y, Sun B, Shi J, Tan C, Wang X.   +7 more
europepmc   +1 more source

Synergism of a Novel 1,2,4-oxadiazole-containing Derivative with Oxacillin against Methicillin-Resistant Staphylococcus aureus. [PDF]

Antibiotics (Basel), 2021
Buommino E, De Marino S, Sciarretta M, Piccolo M, Festa C, D'Auria MV.   +5 more
europepmc   +1 more source

Preparation of crosslinked 1,2,4-oxadiazole polymer

, 1981
New crosslinked 1,2,4-oxadiazole elastomers were prepared by thermally condensing a monomer having the formula H2N(HON)C-R-Q, wherein Q is a triazine ring-forming group such as nitrile or amidine or a mixture of such group with amidoxime, or a mixture of
Shalhoub, I. M., Kwong, H., Rosser, R. W.   +2 more
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Synthesis, enzyme inhibition and molecular docking studies of novel 1,2,4-oxadiazole thioether derivatives

A new series of thioethers containing a 1,2,4-oxadiazole ring were synthesized by the modified Riemschneider reaction. The corresponding thiocyanate derivatives of 1,2,4-oxadiazoles were obtained in good yields by the reaction of 3-aryl-5-chloromethyl-1 ...
Noma, Samir Abbas Ali, Ölmez, Nevin Arıkan, Kaya, Yunus, Osman, Bilgen   +3 more
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The study on 3- phenoxy-1,2,4-oxadiazole derivatives as novel inhibitors for the STAT3 pathways.

, 2012
학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2012. 2. 예상규.STAT3 often found constitutively activated in various human cancer. It is well established that persistently activated STAT3 promotes its downstream genes involved in cell proliferation, survival and growth ...
최지원
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