Results 141 to 150 of about 40,557 (208)

1,2,4-Oxadiazole Derivatives: Physicochemical Properties, Antileishmanial Potential, Docking and Molecular Dynamic Simulations of <i>Leishmania infantum</i> Target Proteins. [PDF]

Molecules
Barbosa DCS, Holanda VN, Lima EMA, Cavalcante MKA, Brelaz-de-Castro MCA, Chaves EJF, Rocha GB, Silva CJO, Oliveira RN, Figueiredo RCBQ.   +9 more
europepmc   +1 more source

New Alpha9 nAChR Ligands Based on a 5-(Quinuclidin-3-ylmethyl)-1,2,4-oxadiazole Scaffold. [PDF]

ACS Chem Neurosci
Dallanoce C, Richter K, Stokes C, Papotto C, Andleeb H, Thakur GA, Kerr A, Grau V, Papke RL.   +8 more
europepmc   +1 more source

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents. [PDF]

RSC Med Chem
Ayoup MS, Barakat MR, Abdel-Hamid H, Emam E, Al-Faiyz YS, Masoud AA, Ghareeb DA, Sonousi A, Kassab AE.   +8 more
europepmc   +1 more source

1,2,4-Oxadiazoles: Synthesis and Applications

Revista Virtual de Química, 2012
Jucleiton José R. de Freitas, Edilma Elayne da Silva, Juliana L. L. F. Regueira, Suelâeny A. de Andrade, Phelipe Matheus M. Calvalcante, Ronaldo N. de Oliveira, João R. de Freitas Filho   +6 more
openaire   +1 more source

Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway. [PDF]

Acta Pharmacol Sin
Luo ZH, Guo JS, Pang S, Dong W, Ma JX, Zhang L, Qi XL, Guan FF, Gao S, Gao X, Liu N, Pan S, Chen W, Zhang X, Zhang LF, Yang YJ.   +15 more
europepmc   +1 more source

Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors. [PDF]

J Enzyme Inhib Med Chem
Mahmoud MA, Mohammed AF, Salem OIA, Almutairi TM, Bräse S, Youssif BGM.   +5 more
europepmc   +1 more source

Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1<i>H</i>-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy. [PDF]

RSC Med Chem
Khedkar NR, Sindkhedkar M, Joseph A.
europepmc   +1 more source

Computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1<i>H</i>-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy. [PDF]

RSC Med Chem
Khedkar NR, Sindkhedkar M, Joseph A.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Bioisosterism: 1,2,4‐Oxadiazole Rings

ChemMedChem, 2023
AbstractAlthough studies in drug discovery have gained momentum in recent years, the conversion of drugs in use today into less toxic derivatives with pharmacologically superior properties is still of great importance in drug research. Bioisosterism facilitates the conversion of drugs into derivatives that present more positive pharmacological and ...
Merve Camci, Nilgün Karali
openaire   +2 more sources

The new era of 1,2,4-oxadiazoles

Organic & Biomolecular Chemistry, 2009
The synthesis, the chemical and photochemical reactivity, and the use of 1,2,4-oxadiazoles in materials and as bioactive compounds have been reviewed. The material in this survey includes some historical background, general features, state-of-the-art applications together with a critical discussion about current limitations and suggestions for future ...
PACE, Andrea, PIERRO, Paola
openaire   +3 more sources