Results 21 to 30 of about 2,851 (224)

Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo

open access: yesФармацевтичний журнал, 2018
Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring.
A. A. Safonov
doaj   +1 more source

Physical-chemical properties of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-il)tio)-1-arylethanons and their reduced systems

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
The aim of work is the investigation of properties of 2-((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanones and 2((5-(3-,4-fluorophenyl)-4-R2-1,2,4-triazol-3-yl)thio)-1-arylethanols using modern physical-chemical methods.Materials and ...
O. A. Bihdan
doaj   +1 more source

Synthesis of diazole-thiols derivatives from l-cysteine: Characterization, complex formation with Ni(II), Cu(II) and evaluation of their antibacterial activity

open access: yesJournal of Saudi Chemical Society, 2021
Four novel diazole-thiol derivatives namely: 5-(1-amino-2-sulfanylethyl)-1,3,4-oxadiazole-2(3H)-thione 6, 4-amino-5-(1-amino-2-sulfanylethyl)-4H-1,2,4-triazole-3-thiol 7, 1-amino-3-(1-amino-2-sulfanylethyl)-1H-1,2,4-triazole-5-thiol 8, and 5-(1-amino-2 ...
Mouna Souad Abbassi   +3 more
doaj   +1 more source

Synthesis and crystal structure of ethyl 2-​{5-​[2-​(2,​6-​dichlorophenylamino)​benzyl]​-​4-​p-​tolyl-​4H-​1,​2,​4-​triazol-​3-​ylthio}​acetate [PDF]

open access: yes, 2014
The compound 2-{5-[2-(2,6-dichlorophenylamino)benzyl]-4-p-tolyl-4H-1,2,4-triazol-3-ylthio}acetate has been prepared and characterized by IR, 1H NMR, 13C NMR and mass spectra. The crystal and molecular structure were further confirmed using single crystal
Gurubasavaraj, V.P.   +2 more
core   +1 more source

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

Synthesis of a Novel 2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)acetaldehyde as a Bisulfite Adduct

open access: yesMolbank, 2023
The scope of the current work was to synthesize an S-alkylated 1,2,4-triazole-3-thiol derivative. Synthesis was carried out in two steps: in the first step, 4,5-diphenyl-4H-1,2,4-triazole-3-thiol was S-alkylated using a halogenated acetal and cesium ...
Beniamin-Nicolae Pintea   +3 more
doaj   +1 more source

Anti-Tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule [PDF]

open access: yes, 2012
The angiogenic process is controlled by variety of factors of which the vascular endothelial growth factor (VEGF) pathway plays a major role. A series of heparan sulfate mimetic small molecules targeting VEGF/VEGFR pathway has been synthesized.
Basappa, .   +3 more
core   +1 more source

Investigation of the Inhibiting Effect of Some Triazole Derivatives for the Corrosion of Mild Steel in 1 M H2SO4 Solution

open access: yesInternational Journal of Electrochemical Science, 2012
The corrosion inhibition of steel in 1.0 M H2SO4 by some triazole derivatives namely, 4-amino-1,2,4-triazole-3-thiol (ATT), 4-amino-5-methyl-1,2,4-triazole-3-thiol (AMTT) and 4-amino-5-ethyl-1,2,4-triazole-3-thiol (AETT) has been studied using ...
Y.H. Ahmad, A.S. Mogoda, A.G. Gadallh
doaj   +1 more source

Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis [PDF]

open access: yes, 2014
Arthritis is a multifactorial disease for which current therapeutic intervention with high efficacy remains challenging. Arthritis predominately affects articular joints, and cartilage deterioration and inflammation are key characteristics.
Dancevic,CM, McCulloch,DR
core   +1 more source

ADME, Synthesis and Antimycobacterial Activity of 1,2,4-Triazol-3-thiol Linked Phenylacetamide Derivatives

open access: yesCurrent Indian Science, 2023
Background:: Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the most contagious and fatal human pathogens which necessitates the development of modified existing drugs or derivatives with action against novel targets. Aims and Objectives:: In the present work, we have explored a few, 2-(5-(substituted)-4H-1,2,4-triazole-2 ...
Trupti Chitre   +6 more
openaire   +1 more source

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