Results 31 to 40 of about 41,174 (227)

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors [PDF]

, 2011
A series of novel 3,5-diamino-1,2,4-triazole benzyl ureas was identified as having potent anaplastic lymphoma kinase (ALK) inhibition exemplified by 15a, 20a, and 23a, which exhibited antiproliferative IC50 values of 70, 40, and 20 nM in Tel-ALK ...
Deng, Xianming, George, Rani E., Gray, Nathanael Schiander, Jänne, Pasi A., Kim, Nam Doo, Luther, William, Sasaki, Takaaki, Sim, Taebo, Wang, Jinhua, Zhang, Jianming   +9 more
core   +2 more sources

Sur la formation «prébiotique» de peptides. Influence d’azoles non condensés et particulièrement du triazole-1,2,4 sur la condensation d’acides α-aminés en milieu aqueux par les polyphosphates

CHIMIA, 1981
With the addition of 1,2,4-triazole or imidazole to aqueous solutions 0.1 M in glycine and 0.1 M in trimetaphosphate at room temperature, pH range 6.7-8.9, the yield of triglycine is improved by a factor of 10 to 20; the best yields are obtained with 1 ...
J. Rabinowitz, A. Hampai
doaj   +1 more source

Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo

Фармацевтичний журнал, 2018
Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring.
A. A. Safonov
doaj   +1 more source

Synthesis methods of 1,2,4-triazole-3-thiones: review

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
1,2,4-Triazole-containing compounds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds used in drug-discovery studies against cancer cells, microbes, and various types of diseases in the human ...
Yu. S. Frolova, A. H. Kaplaushenko, T. V. Ihnatova, T. M. Kaplaushenko   +3 more
doaj   +1 more source

Synthesis and crystal structure of ethyl 2-​{5-​[2-​(2,​6-​dichlorophenylamino)​benzyl]​-​4-​p-​tolyl-​4H-​1,​2,​4-​triazol-​3-​ylthio}​acetate [PDF]

, 2014
The compound 2-{5-[2-(2,6-dichlorophenylamino)benzyl]-4-p-tolyl-4H-1,2,4-triazol-3-ylthio}acetate has been prepared and characterized by IR, 1H NMR, 13C NMR and mass spectra. The crystal and molecular structure were further confirmed using single crystal
Gurubasavaraj, V.P., Nikhath, Fathima, Noor Shahina Begum, .   +2 more
core   +1 more source

Synthesis and establishment of physico-chemical constants 2-(5-( chinoline -2-il, 2-hydroxyquinoline-4-іл)-4-R1-1,2,4-triazole-3-ілтіо) acetate acids and their esther

Фармацевтичний журнал, 2018
The large interest in the plan of search biologically of active agents is caused by the heterocyclic system of 1,2,4-triazole, due to high biological activity, and by the low indexes of toxicness, that inherent it to the structural analogues.
Т. М. Kaplaushenko, О. І. Panasenko, Y. G. Samelyuk   +2 more
doaj   +1 more source

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
About half of the drugs currently produced are chiral compounds, and about 90 % of these compounds are sold as racemates, consisting of an equimolar mixture of two enantiomers.
Ye. O. Karpun, S. O. Borsuk, L. I. Kucherenko, V. V. Parchenko   +3 more
doaj   +1 more source

Synthesis and structural characterization of a disulphide-bridged tetranuclear palladium(II) complex derived from 3,5-diacetyl 1,2,4-triazole bis(4-ethylthiosemicarbazone) [PDF]

, 2007
NOTICE: this is the author’s version of a work that was accepted for publication in Inorganic Chemistry Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Matesanz, Ana I., Pastor, César J., Souza, Pilar   +2 more
core   +2 more sources

Antibacterial and antifungal activity of derivatives 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The amount of antibiotics has increased over the past decade. This also resulted in increase of microorganisms’ resistance to this class of drugs. Therefore, the synthesis of new compounds that have exhibited antimicrobial and antifungal activity and low
O. A. Suhak, O. І. Panasenko, Ye. G. Knysh, O. M. Kamyshny   +3 more
doaj   +1 more source

Poly(1-vinyl-1,2,4-triazolium) poly(ionic liquid)s: synthesis and the unique behavior in loading metal ions

, 2016
Herein we report the synthesis of a series of poly(4-alkyl-1-vinyl-1,2,4-triazolium) poly(ionic liquid)s either via straightforward free radical polymerization of their corresponding ionic liquid monomers, or via anion metathesis of the polymer ...
Yuan, Jiayin, Zhang, Weiyi
core   +1 more source