Results 171 to 180 of about 18,084 (219)

ChemInform Abstract: 1,3,4‐Oxadiazole

ChemInform, 2014
AbstractReview: use of oxadiazole derivatives in in various field like polymer industry and, ost notably, medicinal chemistry; 70 refs.
S. B. Dave, P. Godhani, Y. Ushir
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Novel syntheses of symmetrical 2,5-diaryl-1,3,4-oxadiazoles and 1,4-phenylenebis-1,3,4-oxadiazoles

Russian Chemical Bulletin, 1998
The reactions of trichloromethylarenes with excess hydrazine hydrate in ethanol gives symmetrical 2,5-diaryl-1,3,4-oxadiazoles in 68–96% yields. The reaction of 1,4-bis(trichloromethyl)benzene with acylhydrazines in an ethanol-pyridine mixture gives the corresponding substituted or unsubstituted 1,4-phenylenebis-1,3,4-oxadiazoles in 35–51% yields.
L. I. Belen'kii, S. I. Luiksaar, I. S. Poddubnyi, M. M. Krayushkin   +3 more
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Keto-1,3,4-oxadiazoles as cathepsin K inhibitors

Bioorganic & Medicinal Chemistry Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
James T, Palmer, Bernard L, Hirschbein, Harry, Cheung, John, McCarter, James W, Janc, Z Walter, Yu, Gregg, Wesolowski   +6 more
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THE CHEMISTRY OF 1,3,4-OXADIAZOLE DERIVATIVES

Russian Chemical Reviews, 1964
CONTENTS I. Introduction 508 II. Preparation of mono-substituted 1,3,4-oxadiazoles 508 III. Preparation of symmetrical 2,5-substituted 1,3,4-oxadiazoles 508 IV. Preparation of asymmetrical 2,5-substituted 1,3,4-oxadiazoles 509 V. Preparation of poly-1,3,4-oxadiazoles 511 VI.
E P Nesynov, A P Grekov
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Perfluoro-bis-1,3,4 oxadiazoles

Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1965
1. The hydrazides of perfluorodicarboxylic acids of the general formula NH2NHCO(CF2)nCONHNH2 (n= 3,4,8,12) were produced by the action of hydrazine hydrate on the diethyl esters of the perfluorodicarboxylic acids in alcohol solutions. 2.
M. P. Krasuskaya, D. P. Del'tsova, I. L. Knunyants   +2 more
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1,3,4-Oxadiazoles as Anticancer Agents: A Review

Recent Patents on Anti-Cancer Drug Discovery
Abstract: Among the deadliest diseases, cancer is characterized by tumors or an increased number of a specific type of cell because of uncontrolled divisions during mitosis. Researchers in the current era concentrated on the development of highly selective anticancer medications due to the substantial toxicities of conventional cytotoxic drugs ...
Greesh Kumar, Rajnish Kumar, Avijit Mazumder, null Salahuddin, Upendra Kumar   +4 more
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Aliphatic poly‐1,3,4‐oxadiazoles

Journal of Polymer Science Part A: General Papers, 1965
AbstractThree high molecular weight aliphatic polyoxadiazoles have been prepared by a new route from equimolar amounts of a diphenyl ester of dicarboxylic acid and an anhydrous hydrazine (or a dihydrazide). The resulting polymers have been characterized by microanalysis, intrinsic viscosity, x‐ray diffraction patterns, infrared absorption spectra, and ...
Terunobu Unishi, Masaki Hasegawa
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Pushing the Limits of Oxygen Balance in 1,3,4-Oxadiazoles

Journal of the American Chemical Society, 2017
Gem-trinitromethyl groups were introduced into a 1,3,4-oxadiazole ring to give the first example of a bifunctionalized single five-membered ring with six nitro groups. 2,5-Bis(trinitromethyl)-1,3,4-oxadiazole (12) has a high calculated crystal density of 2.007 g cm-3 at 150 K (1.941 g cm-3 at 293 K) and a very high positive oxygen balance (39.12 ...
Qiong Yu, Ping Yin, Jiaheng Zhang, Chunlin He, Gregory H. Imler, Damon A. Parrish, Jean’ne M. Shreeve   +6 more
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Anti-inflammatory Activity of Substituted 1,3,4-Oxadiazoles

Journal of Pharmaceutical Sciences, 1989
Various 2-(4-biphenoxymethyl)-5-arylamino-1,3,4-oxadiazoles were synthesized by cyclization of the corresponding 1-(4-biphenoxyacetyl)-4-substituted thiosemicarbazides. These compounds were characterized by their elemental analyses and infrared, mass, and nuclear magnetic resonance spectral data.
K, Raman, S S, Parmar, S K, Salzman
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1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents

Mini-Reviews in Medicinal Chemistry, 2011
1,3,4-oxadiazole, a privileged structure, endows its derivatives with broad and potent biological functions, especially in antiviral activities, including anti-HIV, anti-HCV, anti-HBV, anti-HSV activities, etc. Molecular modeling and pharmacokinetic studies have demonstrated that the introduction of 1,3,4-oxadiazole ring to the inhibitors can change ...
Z, Li, P, Zhan, X, Liu
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