Results 121 to 130 of about 34,622 (239)

037-Investigating Singly Substituted 2-amino-1,3,4-oxadiazoles as Antibiotic Drug Candidates [PDF]

1,3,4-Oxadiazoles have shown promise as antibiotic agents, with many papers showing their efficacy against gram positive bacterial strains. However, synthetic methods for these compounds remain hazardous for the user and destructive towards the ...
Klosko, Elizabeth
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Design, Synthesis and Bioactivity Evaluation of Novel 2-(pyrazol-4-yl)-1,3,4-oxadiazoles Containing an Imidazole Fragment as Antibacterial Agents. [PDF]

Molecules, 2023
Liu H, Yang S, Li T, Ma S, Wang P, Wang G, Su S, Ding Y, Yang L, Zhou X, Yang S.   +10 more
europepmc   +1 more source

Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity. [PDF]

J Biol Chem, 2023
Cellupica E, Caprini G, Cordella P, Cukier C, Fossati G, Marchini M, Rocchio I, Sandrone G, Vanoni MA, Vergani B, Źrubek K, Stevenazzi A, Steinkühler C.   +12 more
europepmc   +1 more source

The Synthesis of Potential Insecticides: Haloalkoxy Phenyl Diacylydrazines and 1,3,4-Oxadiazoles [PDF]

, 1983
The syntheses of two classes pf compounds, diacylhydrazines and 2,5-disubstituted 1,3,4-oxadiazoles, intended for subsequent investigation of pesticidal activity are discussed.
Gibbs-Rein, Kathleen S.
core   +1 more source

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3) [PDF]

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions globally, with increasing urban cases outside of Latin America. Treatment is based on two compounds, namely, benznidazole (BZ) and nifurtimox, but chronic cases pose ...
Alonso, Victoria Lucia, Escalante, Andrea Marta, Frattini, Gianfranco, Furlan, Ricardo Luis Eugenio, Moreno, Diego Martin, Rodríguez Araya, Elvio, Serra, Esteban Carlos, Tavernelli, Luis Emilio   +7 more
core   +1 more source

Therapeutic potential of 1,3,4-oxadiazoles as potential lead compounds for the treatment of Alzheimer's disease. [PDF]

RSC Adv, 2023
Naseem S, Temirak A, Imran A, Jalil S, Fatima S, Taslimi P, Iqbal J, Tasleem M, Tahir MN, Shafiq Z.   +9 more
europepmc   +1 more source

Synthesis of 2-aryl-5-(arylsulfonyl)-1,3,4-oxadiazoles as potent antibacterial and antioxidant agents. [PDF]

Turk J Chem, 2022
Murthy BSN, Talari S, Kola AE, Chalapaka B.   +3 more
europepmc   +1 more source

DESIGN, SYNTHESIS, IN VITRO ANTIOXIDANT AND IN VIVO ANTI-INFLAMMATORY ACTIVITIES OF NOVEL OXADIAZOLE DERIVATIVES [PDF]

, 2014
Objective: In the present study, a series of novel 1,3,4-oxadiazole derivatives (3a-3q) were designed, synthesized and evaluated for antioxidant and anti-inflammatory activities.Methods: The title compounds were designed and docked onto the COX-2 enzyme (
Gurupadayya, B. M., Inturi, Bharat Kumar, Sairam, K. Venkata, Vishwanathan, B.   +3 more
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Copper-Catalyzed One-Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from Arylacetic Acids and Hydrazides via Dual Oxidation. [PDF]

ACS Omega, 2022
Lekkala C, Bodala V, Yettula K, Karasala BK, Podugu RL, Vidavalur S.   +5 more
europepmc   +1 more source

Synthesis of 2-(β-D-glucopyranosylamino)-5-substituted-1,3,4-oxadiazoles for inhibition of glycogen phosphorylase [PDF]

, 2019
Docsa, Tibor, Gergely, Pál, Kaszás, Tímea, Somsák, László, Szőcs, Béla, Tóth, Marietta   +5 more
core   +1 more source