Results 161 to 170 of about 34,622 (239)

Greening of Monocyclic N- and O‑Azole Synthesis through Sonochemistry. [PDF]

ACS Omega
Hoffman GR, Saeed MM, Schoffstall AM.
europepmc   +1 more source

Promising Norlabdane-Heterocyclic Hybrids: Synthesis, Structural Characterization and Antimicrobial Activity Evaluation. [PDF]

Pharmaceuticals (Basel)
Lungu L, Ciocarlan A, Mangalagiu II, Aricu A.   +3 more
europepmc   +1 more source

Novel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs.

Indian J Pharmacol, 2014
Durgashivaprasad E, Mathew G, Sebastian S, Reddy SA, Mudgal J, Nampurath GK.   +5 more
europepmc   +1 more source

Hydrazides as Powerful Tools in Medicinal Chemistry: Synthesis, Reactivity, and Biological Applications. [PDF]

Molecules
Teixeira S, Castanheira EMS, Carvalho MA.   +2 more
europepmc   +1 more source

A two-decade overview of oxadiazole derivatives as promising anticancer agents. [PDF]

RSC Adv
Salem M, El-Adl K, El-Morsy A, Abulkhair HS.   +3 more
europepmc   +1 more source

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1,3,4-Oxadiazoles as Anticancer Agents: A Review

Recent Patents on Anti-Cancer Drug Discovery, 2023
Abstract: Among the deadliest diseases, cancer is characterized by tumors or an increased number of a specific type of cell because of uncontrolled divisions during mitosis. Researchers in the current era concentrated on the development of highly selective anticancer medications due to the substantial toxicities of conventional cytotoxic drugs ...
Greesh Kumar, Rajnish Kumar, Avijit Mazumder, null Salahuddin, Upendra Kumar   +4 more
openaire   +3 more sources

Regioselective Synthesis of 2,5-Disubstituted-1,3,4-thiadiazoles and 1,3,4-Oxadiazoles via Alkyl 2-(Methylthio)-2-thioxoacetates and Alkyl 2-Amino-2-thioxoacetates.

Journal of Organic Chemistry, 2023
An acid-catalyzed regioselective cyclization reaction of 2,5-disubstituted-1,3,4-thiadiazoles and 1,3,4-oxadiazoles has been developed. The synthetic precursors alkyl 2-(methylthio)-2-thioxoacetates/alkyl 2-amino-2-thioxoacetates react efficiently with ...
C. Santhosh, Krishna Ravi Singh, K. Sheela, T. Swaroop, M. P. Sadashiva   +4 more
semanticscholar   +1 more source

Identification of 1,3,4-oxadiazoles as tubulin-targeted anticancer agents: a combined field-based 3D-QSAR, pharmacophore model-based virtual screening, molecular docking, molecular dynamics simulation, and density functional theory calculation approach

Journal of Biomolecular Structure and Dynamics, 2023
Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial protein of cytoskeleton that maintains essential cellular functions including cell division as well as cell signalling, that makes an attractive drug target for cancer
Agnidipta Das, Manaswini Sarangi, Kailash Jangid, Vijay Kumar, Amit Kumar, P. Singh, Kamalpreet Kaur, Vinod Kumar, Sudip Chakraborty, Vikas Jaitak   +9 more
semanticscholar   +1 more source

Discovery of New 1,3,4-Oxadiazoles with Dual Activity Targeting the Cholinergic Pathway as Effective Anti-Alzheimer Agents.

ACS Chemical Neuroscience, 2022
Finding an effective anti-Alzheimer agent is quite challenging due to its multifactorial nature. As such, multitarget directed ligands (MTDLs) could be a promising paradigm for finding potential therapeutically effective new small-molecule bioactive ...
Nehal H Elghazawy, Dalia K. Zaafar, Reham R Hassan, M. Mahmoud, Loay Bedda, Alaa F. Bakr, Reem K. Arafa   +6 more
semanticscholar   +1 more source

Synthesis, antibacterial activity and in silico study of new bis(1,3,4-oxadiazoles)

Synthetic Communications, 2022
In the current study, new bis(2,5-disubstituted 1,3,4-oxadiazoles) linked to aliphatic cores were efficiently prepared. For this purpose, the appropriate bis(aldehydes) and benzohydrazides were reacted to produce the corresponding bis(N-benzoylhydrazones)
A. Abdelfattah, Ahmed E. M. Mekky, S. Sanad   +2 more
semanticscholar   +1 more source