Results 171 to 180 of about 37,093 (255)

1,3,4-Oxadiazoles as Anticancer Agents: A Review

Recent Patents on Anti-Cancer Drug Discovery, 2023
Abstract: Among the deadliest diseases, cancer is characterized by tumors or an increased number of a specific type of cell because of uncontrolled divisions during mitosis. Researchers in the current era concentrated on the development of highly selective anticancer medications due to the substantial toxicities of conventional cytotoxic drugs ...
Greesh Kumar, Rajnish Kumar, Avijit Mazumder, null Salahuddin, Upendra Kumar   +4 more
openaire   +3 more sources

Trimethylsilyl-1,3,4-oxadiazoles—new useful synthons for the synthesis of various 2,5-disubstituted-1,3,4-oxadiazoles

Tetrahedron, 2008
Abstract The reactivity of 2-aryl-5-trimethylsilyl-1,3,4-oxadiazoles toward different types of electrophiles was investigated. These silanes readily react with chlorine, bromine, aliphatic acyl chlorides, 2-nitrobenzenesulfenyl chloride, and some reactive isocyanates affording the corresponding substituted 1,3,4-oxadiazoles.
Evgeniy V Zarudnitskii
exaly   +2 more sources

Identification of 1,3,4-oxadiazoles as tubulin-targeted anticancer agents: a combined field-based 3D-QSAR, pharmacophore model-based virtual screening, molecular docking, molecular dynamics simulation, and density functional theory calculation approach

Journal of Biomolecular Structure and Dynamics, 2023
Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial protein of cytoskeleton that maintains essential cellular functions including cell division as well as cell signalling, that makes an attractive drug target for cancer
Agnidipta Das, Manaswini Sarangi, Kailash Jangid, Vijay Kumar, Amit Kumar, P. Singh, Kamalpreet Kaur, Vinod Kumar, Sudip Chakraborty, Vikas Jaitak   +9 more
semanticscholar   +1 more source

Synthesis, antibacterial activity and in silico study of new bis(1,3,4-oxadiazoles)

Synthetic Communications, 2022
In the current study, new bis(2,5-disubstituted 1,3,4-oxadiazoles) linked to aliphatic cores were efficiently prepared. For this purpose, the appropriate bis(aldehydes) and benzohydrazides were reacted to produce the corresponding bis(N-benzoylhydrazones)
A. Abdelfattah, Ahmed E. M. Mekky, S. Sanad   +2 more
semanticscholar   +1 more source

Potential Synthetic Routes and Metal-Ion Sensing Applications of 1,3,4-Oxadiazoles: An Integrative Review

Critical reviews in analytical chemistry, 2022
Oxadiazoles, especially 1,3,4-oxadiazole scaffolds, stand among the foremost heterocyclic fragments with a broad spectrum of applications in diverse fields, including pharmacology, polymers, material science, and organic electronics, among others.
D. Sharma, H. Om, A. Sharma
semanticscholar   +1 more source

Perfluoro-1,3,4-oxadiazoles

Journal of Fluorine Chemistry, 1992
Abstract Some new polyfluorinated 1,3,4-oxadiazoles have been obtained via a two-step method. The cycloadditions of the 1,3,4-oxadiazoles have been studied and an analysis of the energies of the frontier orbitals calculated by the MNDO method indicates a LUMO-dependent pathway for cycloaddition.
N.V. Vasiliev, Yu.E. Lyashenko, A.E. Patalakha, G.A. Sokolski   +3 more
openaire   +1 more source

Two antioxidant 2,5-disubstituted-1,3,4-oxadiazoles (CoViTris2020 and ChloViD2020): successful repurposing against COVID-19 as the first potent multitarget anti-SARS-CoV-2 drugs

, 2020
Repurposing of known drugs and compounds as anticoronavirus disease 2019 (anti-COVID-19) agents through biological reevaluation of their activities, specially the antisevere acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities, is a new ...
A. Rabie
semanticscholar   +1 more source

Synthesis, anticancer evaluation and molecular docking studies of 2,5-bis(indolyl)-1,3,4-oxadiazoles, Nortopsentin analogues

Journal of Molecular Structure, 2020
A series of ten novel 2,5-bis(indolyl)-1,3,4-oxadiazoles were designed and synthesized. All these compounds were evaluated for their cytotoxicity against four cancer cell lines namely A549, MDA-MB-231, MCF-7 and HeLa using MTT reduced assay.
R. Sreenivasulu, M. B. Tej, S. S. Jadav, P. Sujitha, C. Kumar, R. Raju   +5 more
semanticscholar   +1 more source

Poly‐1,3,4‐oxadiazoles. I. Polyphenylene‐1,3,4‐oxadiazoles

Journal of Polymer Science Part A: General Papers, 1965
AbstractPolyphenylene‐1,3,4‐oxadiazoles have been prepared from benzenedicarboxylic acids or their derivatives and hydrazine by solution polycondensation in fuming sulfuric acid or polyphosphoric acid. These polymers were characterized by good thermal stability, and the molecular weights attained were high enough for the products to exhibit fiber‐or ...
Yoshio Iwakura, Keikichi Uno, Shigeyoshi Hara   +2 more
openaire   +1 more source

Infrared spectra of 1,3,4-oxadiazole and 2,5,-dimethyl-1,3,4-oxadiazole. Vibrational assignment of 1,3,4-oxadiazole

Journal of Molecular Spectroscopy, 1967
Abstract The infrared absorption spectrum of 1,3,4-oxadiazole has been recorded in the region 5000-400 cm −1 in the vapor and in the liquid phases, in CS 2 and C 2 Cl 4 solutions. Also, the infrared absorption spectrum of liquid 2,5-dimethyl-1,3,4-oxadiazole was recorded in the same region. A tentative assignment of the fundamental vibrations of 1,
Daniel Højgaard Christensen, Jørgen Tormod Nielsen, Ole Faurskov Nielsen   +2 more
openaire   +1 more source