Results 71 to 80 of about 27,886 (261)

(SP,SP)-(–)-(E)-1,2-Bis(methylphenylphosphinoyl)ethene

Acta Crystallographica Section E, 2009
The title compound, C16H18O2P2, possesses two stereogenic P atoms and shows a distorted s–cis conformation of each O=P—C=C moiety. This has been suggested on the basis of the stereochemical result of 1,3-dipolar cycloadditions with ...
doaj   +1 more source

Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides

Advanced Science, EarlyView.
A Mn(II)‐catalyzed electrochemical method achieves site‐selective diazidation of dehydroalanine peptides with NaN₃. This radical relay process tolerates diverse functional groups, delivers high yields, and enables precise peptide modification, offering a powerful tool for bioconjugation and therapeutic development.
Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan   +5 more
wiley   +1 more source

Reaktivität von Pnictaalumenen gegenüber 1,3‐Dipol‐Molekülen

Angewandte Chemie, EarlyView.
Pnictaalumene mit einer Pn = Al‐Mehrfachbindung unterliegen eher Azid‐ oder Diazoalken‐Insertionen als [3+2]‐Cycloadditionen. Dies führt zu AlN2Pn‐Heterocyclen, die je nach sterischem Anspruch des Azids eine große strukturelle Vielfalt aufweisen.
Tim Wellnitz, Edgar Zander, Leonie Wüst, Jakob Boardman, Max Neubauer, Samuel Nees, Holger Braunschweig, Christian Hering‐Junghans   +7 more
wiley   +1 more source

Triazole-oligomers by 1,3-dipolar cycloaddition [PDF]

Arkivoc, 2006
A variety of triazole-oligomers have been prepared under microwave and conventional conditions from novel alkynes and azides.
Rong Jiang, Kazuyuki Suzuki, Geoffroy L. Sommen, Nabin K. Meher, David A. Ciaramitaro, Sandeep K. Singh, Peter J. Steel, Jacek Doskocz, Alan R. Katritzky   +8 more
openaire   +2 more sources

Coumarin–Tetrapyrrolic Macrocycle Conjugates: Synthesis and Applications

Molecules, 2017
This review covers the synthesis of coumarin–porphyrin, coumarin–phthalocyanine and coumarin–corrole conjugates and their potential applications. While coumarin–phthalocyanine conjugates were obtained almost exclusively by tetramerization of coumarin ...
Ana F. R. Cerqueira, Vítor A. S. Almodôvar, Maria G. P. M. S. Neves, Augusto C. Tomé   +3 more
doaj   +1 more source

Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity

Molecules, 2023
Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and ...
Hua Zhao, Yufen Zhao
doaj   +1 more source

Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey [PDF]

, 2009
With the goal of identifying alkyne-like reagents for use in click chemistry, but without Cu catalysts, we used B3LYP density function theory (DFT) to investigate the trends in activation barriers for the 1,3-dipolar cycloadditions of azides with various
Chenoweth, David, Chenoweth, Kimberly, Goddard, William A. III   +2 more
core   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

X=Y–ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions [PDF]

, 2008
1,3-Dipolar reactions of imines of both acyclic and cyclic α-amino esters with a range of nitroolefins using a combination of AgOAc or Ag2O with NEt3 are described.
Albert, Amornraksa, Ayerbe, Becker, Berger, Bourguignon, Bryce, Cecilia Orgaz de la Cierva, Colin Kilner, Crooks, Dondas, Díaz-Ortiz, Fejes, Fejes, Gentles, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, H. Ali Dondas, Hill, Kabalka, Krapcho, Lee, Mohammed A.B. Sarker, Nielson, Norman, Nyerges, Nyerges, Nyerges, Nyerges, Nyerges, Pak, Peterli, Pinna, Poornachandran, Poornachandran, Poornachandran, Ram, Rang, Ronald Grigg, Sader-Bakaouni, Shorter, Song, Thurkauf, Vivanco, Yan   +51 more
core   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source