Results 171 to 180 of about 5,065 (202)
Some of the next articles are maybe not open access.
1,4-Dihydropyridines containing sulfur (review)
Chemistry of Heterocyclic Compounds, 1995The literature on the synthesis and reactions of monocyclic and polycyclic 1, 4-dihydropyridines containing sulfur in substituents or in the ring is reviewed.
Ya. Ozols, B. Vigante, G. Duburs
openaire +1 more source
Vicinal diamination of 1,4-dihydropyridines
Chemical Communications, 1998Electrophilic interaction of iodine with N-alkyl-1,4-dihydropyridines 1 in the presence of secondary amines stereoselectively leads to the corresponding trans-2,3-diamino-1,2,3,4-tetrahydropyridines 2 in satisfactory yields (79–94%); the method allows the synthesis of piperidine, pyrrolidine, morpholine and piperazine derivatives.
Rodolfo Lavilla +4 more
openaire +1 more source
Reactions of 1,4-dihydropyridines (review)
Chemistry of Heterocyclic Compounds, 1993The literature published over the period 1986–1990 on the chemical properties (oxidation, addition, substitution, reactions of the functional groups, etc.) of 1,4-dihydropyridines is correlated.
A. Sausin'sh, G. Dubur
openaire +1 more source
The oxidation of 1,4-dihydropyridines
Chemistry of Heterocyclic Compounds, 1970The olefinic bond of methenylbisindan-1,3-dione, 2-benzylideneindan-1, 3-dione, and its derivatives is easily reduced by many 1, 4-dihydropyridines. Under the conditions described, other functional groups are untouched. These Β-dicarbonyl compounds are utilized to compare the effects of substituents in 1,4-dihydropyridines on their reactivity in the ...
G. Ya. Dubur, Ya. R. Uldrikis
openaire +1 more source
Metalation of 1,4-dihydropyridine esters
Tetrahedron Letters, 1989Abstract 4-Aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic esters are metalated at the NH and the C-2 methyl positions via tretament with two equivalents of n-butyl lithium. The resulting dilithio species can be treated with a variety of electrophiles to furnish C-2 methyl functionalized dihydropyridine esters.
Graham S. Poindexter +2 more
openaire +1 more source
The photochemistry of 3,5-disubstituted 1,4-dihydropyridines
Tetrahedron, 1970Abstract On irradiation, 1,4-dihydropyridines have been shown to undergo three types of reaction: disproportionation, isomerization and dimerization. The presence of 2,6-substituents inhibits these reactions except in the case of 3a which undergoes disproportionation.
U, Eisner +3 more
openaire +2 more sources
Aromatization of 1,4‐Dihydropyridines with Selenium Dioxide.
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiao-hua Cai +2 more
openaire +1 more source
Dimeric 1,4-dihydropyridines as calcium channel antagonists
Journal of Medicinal Chemistry, 1988A series of 1,n-alkanediylbis(1,4-dihydropyridines) (n = 2, 4, 6, 8, 10, 12) bridged at C3 of 2,6-dimethyl-3-carboxy-5-carbethoxy-4-(3-nitrophenyl)-1,4-dihydropyridin e were synthesized and evaluated in a radioligand binding assay, [3H]nitrendipine in intestinal smooth muscle, as Ca2+ channel ligands.
A F, Joslyn, E, Luchowski, D J, Triggle
openaire +2 more sources
1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor
1993The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
openaire +1 more source
1,4-Dihydropyridine activators in the tiamdipine series
European Journal of Pharmacology, 1990The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart.
GALLETTI, FERRUCCIO +2 more
openaire +3 more sources