Results 1 to 10 of about 167,559 (248)

Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA [version 3; peer review: 1 approved, 3 approved with reservations, 1 not approved]

Open Research Africa, 2023
Background Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa.
Peter Mwitari, Francis Kimani, Daniel Kiboi, Brenda Muriithi, Jean Chepngetich, Kevin Thiong'o, Beatrice Gachie, Jeremiah Gathirwa, Mercy Jepkorir   +8 more
doaj   +2 more sources

Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPlatelet‐derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension.
Yanjiao Li, Li Li, Zhengjiang Qian, Boya Lin, Jidong Chen, Yixuan Luo, Junle Qu, J. Usha Raj, Deming Gou   +8 more
doaj   +2 more sources

A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion

Nature Communications, 2023
Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs) dock and fuse with the plasma membrane. However, MVEs are also known to fuse with lysosomes for degradation.
Di-Ao Liu, Kai Tao, Bin Wu, Ziyan Yu, Malwina Szczepaniak, Matthew Rames, Changsong Yang, Tatyana Svitkina, Yueyao Zhu, Fengyuan Xu, Xiaolin Nan, Wei Guo   +11 more
doaj   +1 more source

Insulin-like growth factor-1 stimulates retinal cell proliferation via activation of multiple signaling pathways

Current Research in Neurobiology, 2023
Insulin-like growth factor-1 (IGF-1) plays critical roles in the development of the central nervous system (CNS), including the retina, regulating cell proliferation, differentiation, and survival.
Camila Saggioro de Figueiredo, Ícaro Raony, Simone Vidal Medina, Eliezer de Mello Silva, Aline Araujo dos Santos, Elizabeth Giestal-de-Araujo   +5 more
doaj   +1 more source

Preparation, chemical structure, and immunostimulatory activity of a water-soluble heteropolysaccharide from Suillus granulatus fruiting bodies

Food Chemistry: X, 2022
A water-soluble heteropolysaccharide (SGP2-1) was purified from Suillus granulatus fruiting bodies by anion-exchange chromatography and gel permeation chromatography.
Xiong Gao, Ranhua Zeng, Chi-Tang Ho, Bin Li, Shaodan Chen, Chun Xiao, Huiping Hu, Manjun Cai, Zhongzheng Chen, Yizhen Xie, Qingping Wu   +10 more
doaj   +1 more source

Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition [PDF]

Brazilian Journal of Medical and Biological Research, 2015
The present study investigated the effect of silibinin, the principal potential anti-inflammatory flavonoid contained in silymarin, a mixture of flavonolignans extracted from Silybum marianum seeds, on palmitate-induced insulin resistance in C2C12 ...
H.B. Li, Y.R.Y. Yang, Z.J. Mo, Y. Ding, W.J. Jiang   +4 more
doaj   +4 more sources

Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells

Food Science and Human Wellness, 2023
Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional activities. In this study, apigenin, luteolin, and baicalein were chosen to evaluate their anti-diabetic effect in high-glucose and dexamethasone ...
Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao   +12 more
doaj   +1 more source

Polyphenol from Rosaroxburghii Tratt Fruit Ameliorates the Symptoms of Diabetes by Activating the P13K/AKT Insulin Pathway in db/db Mice

Foods, 2022
About 4% of the world’s population has type 2 diabetes mellitus (T2DM), and the available hypoglycemic drugs for treating diabetes have some side effects.
Chao Chen, Shuming Tan, Tingyuan Ren, Hua Wang, Xiaotong Dai, Hui Wang   +5 more
doaj   +1 more source

Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?

Lipids in Health and Disease, 2017
Background Undernutrition during childhood leads to chronic diseases in adult life including hypertension, diabetes and chronic kidney disease. Here we explore the hypothesis that physiological alterations in the bioactive lipids pattern within kidney ...
Luzia S. Sampaio, Paulo A. da Silva, Valdilene S. Ribeiro, Carmem Castro-Chaves, Lucienne S. Lara, Adalberto Vieyra, M. Einicker-Lamas   +6 more
doaj   +1 more source

Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-κB, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKKβ/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation

Antioxidants, 2021
Liver damage induced by paracetamol overdose is the main cause of acute liver failure worldwide. In order to study the hepatoprotective effect of Sanghuangporus sanghuang mycelium (SS) on paracetamol-induced liver injury, SS was administered orally every
Wen-Ping Jiang, Jeng-Shyan Deng, Shyh-Shyun Huang, Sheng-Hua Wu, Chin-Chu Chen, Jung-Chun Liao, Hung-Yi Chen, Hui-Yi Lin, Guan-Jhong Huang   +8 more
doaj   +1 more source