Results 1 to 10 of about 317,690 (321)

A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 [PDF]

Clinical Infectious Diseases, 2020
Background MMV390048 is the first Plasmodium phosphatidylinositol 4-kinase inhibitor to reach clinical development as a new antimalarial. We aimed to characterize the safety, pharmacokinetics, and antimalarial activity of a tablet formulation of ...
James McCarthy, Cristina Donini, Stephan Chalon, John Woodford, Louise Marquart, Katharine A. Collins, Felix D. Rozenberg, David A. Fidock, Mohammed H. Cherkaoui‐Rbati, Nathalie Gobeau, Jörg J. Möhrle   +10 more
openalex   +2 more sources

Interaction of Neuronal Calcium Sensor-1 and ADP-ribosylation Factor 1 Allows Bidirectional Control of Phosphatidylinositol 4-Kinase β and trans-Golgi Network-Plasma Membrane Traffic [PDF]

Journal of Biological Chemistry, 2004
We have identified a novel Ca2+-dependent interaction between neuronal calcium sensor-1 (NCS-1) and the GTPase ARF1. Both of these proteins are localized to the Golgi complex, and both regulate phosphatidylinositol 4-kinase IIIβ (PI(4)Kβ).
Lee P. Haynes, Geraint Thomas, Robert D. Burgoyne   +2 more
openalex   +2 more sources

Interaction of Neuronal Calcium Sensor-1 (NCS-1) with Phosphatidylinositol 4-Kinase β Stimulates Lipid Kinase Activity and Affects Membrane Trafficking in COS-7 Cells

Journal of Biological Chemistry, 2001
Phosphatidylinositol 4-kinases (PI4K) catalyze the first step in the synthesis of phosphatidylinositol 4,5-bisphosphate, an important lipid regulator of several cellular functions.
Xiaohang Zhao, Péter Várnai, Galina Tuymetova, András Balla, Zsuzsanna Tóth, Christian Oker‐Blom, John Roder, Andreas Jeromin, Tamás Balla   +8 more
openalex   +2 more sources

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

PLoS Pathogens, 2013
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an essential host factor of hepatitis C virus (HCV) replication. PI4KIIIα catalyzes the synthesis of phosphatidylinositol 4-phosphate (PI4P) accumulating in HCV replicating cells due ...
Simon Reiss, Christian Harak, Inés Romero-Brey, Danijela Radujkovic, Rahel Klein, Alessia Ruggieri, Ilka Rebhan, Ralf Bartenschlager, Volker Lohmann   +8 more
doaj   +2 more sources

NCS-1 Inhibits Insulin-stimulated GLUT4 Translocation in 3T3L1 Adipocytes through a Phosphatidylinositol 4-Kinase-dependent Pathway [PDF]

Journal of Biological Chemistry, 2002
Expression of NCS-1 (neuronal calcium sensor-1, also termed frequenin) in 3T3L1 adipocytes strongly inhibited insulin-stimulated translocation of GLUT4 and insulin-responsive aminopeptidase.
Sílvia Mora, Paul L. Durham, Jeffery R. Smith, Andrew F. Russo, Andreas Jeromin, Jeffrey E. Pessin   +5 more
openalex   +2 more sources

Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPlatelet‐derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension.
Yanjiao Li, Li Li, Zhengjiang Qian, Boya Lin, Jidong Chen, Yixuan Luo, Junle Qu, J. Usha Raj, Deming Gou   +8 more
doaj   +2 more sources

ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes

Frontiers in Immunology, 2017
Phosphatidylinositol 4,5-biphosphate (PIP2) is a membrane phospholipid that controls the activity of several proteins regulating cytoskeleton reorganization, cytokine gene expression, T cell survival, proliferation, and differentiation ...
Loretta Tuosto, Martina Kunkl, Nicla Porciello, Marta Mastrogiovanni, Cristina Capuano, Federica Lucantoni, Chiara Moretti, Jenny L. Persson, Jenny L. Persson, Ricciarda Galandrini, Raffaella Buzzetti   +10 more
doaj   +2 more sources

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic β cells through activation of phosphatidylinositol 4-kinase β [PDF]

, 2005
Cytosolic free Ca2+ plays an important role in the molecular mechanisms leading to regulated insulin secretion by the pancreatic β cell. A number of Ca2+-binding proteins have been implicated in this process.
Jesper Gromada, Christina Bark, Kamille Smidt, Alexander M. Efanov, Juliette Janson, Slavena A. Mandic, Dominic‐Luc Webb, Wei Zhang, Björn Meister, Andreas Jeromin, Per‐Olof Berggren   +10 more
openalex   +2 more sources

The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky–Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα

Molecular Biology of the Cell, 2013
The WASH complex, an endosomal activator of the Arp2/3 complex involved in branched actin polymerization, is identified as a new factor in vesicle traffic mediated by the Hermansky–Pudlak syndrome complex BLOC-1.
Pearl V. Ryder, Rachel Vistein, A.M. Gokhale, Matthew Seaman, Manojkumar A. Puthenveedu, Victor Faúndez   +5 more
openalex   +2 more sources

Specificity, Promiscuity and Localization of ARF Protein Interactions with NCS‐1 and Phosphatidylinositol‐4 Kinase‐IIIβ [PDF]

Traffic : the International Journal of Intracellular Transport, 2007
Lee P. Haynes, Mark W. Sherwood, Nick J. Dolman, Robert D. Burgoyne   +3 more
openalex   +2 more sources